Effect of an acute zinc depletion on rat lipoprotein distribution and peroxidation

Faure, Patrice; Roussel, Anne Marie; Richard, M J; Foulon, T; Groslambert, P; Hadjian, Arthur J.; Favier, Alain

doi:10.1007/bf02863079

Cited by 47 publications

(24 citation statements)

References 30 publications

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“…The polyphenolic structures of flavonoids partition into the hydrophobic core of the membrane can cause a modulation of lipid fluidity (Arti et al, 2000). Flavonoids have been reported to inhibit peroxidation of polyunsaturated fatty acids in cell membranes (Faure et al, 1990). These substances, could react with the deeper membrane domains and intracellular structures, and protect the cells from oxidant injury (Kaviarasan et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the antioxidant effects of <i>Ziziphus mauritiana</i> lam. leaf extracts against chronic ethanol-induced hepatotoxicity in rat liver

Dahiru¹,

Obidoa²

2008

Afr. J. Trad. Compl. Alt. Med.

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Chronic alcohol ingestion is known to increase the generation of reactive oxygen species (ROS), thereby leading to liver damage. Antioxidant enzymes act individually or in combination to reduce or counter the effect of these ROS. Chronic administration of alcohol at (40% v/v, 1ml/100g), for 6 weeks showed a significant (p<0.05) elevated levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bilirubin (TB). There was also a significant (p<0.05) decreased levels of catalase, glutathione peroxidase, glutathione reductase and superoxide dismutase compared to control rats. Pretreatment of rats with 200, 400 mg/kg body weight of aqueous leaf extract of Ziziphus mauritiana or 100 mg/kg silymarin resulted in a significant (p<0.05) decreased levels of ALT, AST, ALP, and TB with levels of catalase, glutathione peroxidase, glutathione reductase and superoxide dismutase showing a significant (p<0.05) increase compared to group administered alcohol only. Histopathology of rat liver administered with alcohol only resulted in severe necrosis, mononuclear cell aggregation and fatty degeneration in the central and mid zonal areas which was a characteristic of a damaged liver. Pre-treatment with the aqueous extract of Ziziphus mauritiana or silymarin reduced the morphological changes that are associated with chronic alcohol administration. The presence of tannins, saponins and phenolic compounds observed in the plant extract could be responsible for the observed effects of decreasing the levels of injured tissue marker and lipid peroxidation.

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Section: Resultsmentioning

confidence: 99%

Evaluation of the antioxidant effects of <i>Ziziphus mauritiana</i> lam. leaf extracts against chronic ethanol-induced hepatotoxicity in rat liver

Dahiru¹,

Obidoa²

2008

Afr. J. Trad. Compl. Alt. Med.

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“…Previous study on this plant revealed the presence of flavonoids, proanthocyanidins, tannins, phenols and flavonols in this plant. These compounds have been reported to possess strong antioxidant capacity [7] , therefore, could inhibit peroxidation of polyunsaturated fatty acids in the cell membrane and haemolysis of red blood cells in the diabetic animals reported by Torell and Faure et al [22,23] .…”

Section: Discussionmentioning

confidence: 97%

Antidiabetic and haematological effect of aqueous extract of stem bark of Afzelia africana (Smith) on streptozotocin–induced diabetic Wistar rats

Aiyegoro

et al. 2011

Asian Pacific Journal of Tropical Biomedicine

103

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“…9 -11 Dietary zinc supplementation in cholesterol-fed rabbits decreases the extent of lesion lipid oxidation and attenuates atherosclerotic burden, despite insignificant changes in lesion zinc. 19 -21 Zinc deficiency in rats has been reported to enhance LDL oxidation in vitro 36 and in LDL-receptor deficient mice to result in increases in plasma lipids and induction of proinflammatory events. 37 However, zinc supplementation of apoE-deficient mice on a high-fat high-cholesterol diet did not confer protection.…”

Section: Discussionmentioning

confidence: 99%

Accumulation of Zinc in Human Atherosclerotic Lesions Correlates With Calcium Levels But Does Not Protect Against Protein Oxidation

Stadler

Stanley

Heeneman

et al. 2008

ATVB

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Objective-Oxidized lipids and proteins, as well as decreased antioxidant levels, have been detected in human atherosclerotic lesions, with oxidation catalyzed by iron and copper postulated to contribute to lesion development. Zinc has been postulated to displace iron from critical sites and thereby protect against damage. In this study, metal ion and protein oxidation levels were quantified in human carotid and abdominal artery specimens containing early-to-advanced lesions, to determine whether zinc concentrations correlate inversely with iron levels and protein oxidation. Methods and Results-Metal ions were quantified by EPR and inductively coupled plasma mass spectroscopy. Native and oxidized protein side-chains were quantified by high-performance liquid chromatography. A therosclerosis is a multifactorial disease to which many factors contribute; defining the role of each of these has proved to be problematic. Oxidation, and in particular that of low-density lipoproteins (LDL), has been linked to disease development, 1 although the significance of this process has not been fully established (reviewed 2 ). Previous studies have variously implicated lipoxygenase, peroxynitrite, myeloperoxidase, oxygen radicals, and metal-ions in lesion oxidation (reviewed 2 ). In the case of metal ions, a correlation between iron accumulation and the extent of protein (but not lipid) oxidation has been reported for human lesions. 3 Cholesterol ester and cholesterol accumulation also correlate positively with iron, suggesting that these processes are interlinked. 3,4 These data are consistent with some, but not all, epidemiological studies on the potential links between iron and cardiovascular disease. [5][6][7][8] Zinc ions have been reported to modulate oxidant damage via the displacement of iron and copper from oxidationsensitive sites on erythrocyte membranes, 9 LDL, 10 or liposomes. 11 Epidemiological data indicate that elevated serum zinc levels may be protective against disease. 12 Serum or plasma measurements of zinc in people with established atherosclerosis indicate that low zinc levels are associated with increased disease 13,14 and a postmortem study has reported lower tissue levels of zinc in the abdominal aorta of patients who died of heart disease compared to other causes. 15 In contrast, zinc supplementation of the human diet does not affect the susceptibility of LDL to oxidation ex vivo 16,17 or the concentrations of LDL-cholesterol, total cholesterol, or triglycerides, but has an adverse effect on high-density lipoprotein levels, suggesting that high serum zinc levels may promote disease. 17 Elevated zinc may stimulate the formation of oxidants and inhibit protective enzymes in some cells. 18 Atherosclerotic lesions of cholesterol-fed rabbits contain elevated levels of iron and reduced levels of zinc. 19 -21 Zinc supplementation, via dietary feeding, reduced lesion area despite insignificant changes in lesion zinc concentrations; these changes were ascribed to a displacement of iron by zinc. 20 Zinc supplement...

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Effect of an acute zinc depletion on rat lipoprotein distribution and peroxidation

Cited by 47 publications

References 30 publications

Evaluation of the antioxidant effects of <i>Ziziphus mauritiana</i> lam. leaf extracts against chronic ethanol-induced hepatotoxicity in rat liver

Evaluation of the antioxidant effects of <i>Ziziphus mauritiana</i> lam. leaf extracts against chronic ethanol-induced hepatotoxicity in rat liver

Antidiabetic and haematological effect of aqueous extract of stem bark of Afzelia africana (Smith) on streptozotocin–induced diabetic Wistar rats

Accumulation of Zinc in Human Atherosclerotic Lesions Correlates With Calcium Levels But Does Not Protect Against Protein Oxidation

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