Effect of an acute exercise bout on immediate post‐exercise irisin concentration in adults: A meta‐analysis

Fox, Jill; Rioux, Brittany V.; Goulet, Eric; Johanssen, Neil M.; Swift, Damon L.; B̀ouchard, Danielle R.; Loewen, Hal; Sénéchal, Martin

doi:10.1111/sms.12904

Cited by 115 publications

(78 citation statements)

References 52 publications

(201 reference statements)

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“…Our results also agree with a recent meta‐analysis conducted by our group suggesting that irisin, like many other hormones, increases acutely in the blood (Fox et al. ). However, in this meta‐analysis, no data were available to perform a subanalysis investigating the acute irisin response in obese individuals compared to normal weight individuals.…”

Section: Discussionsupporting

confidence: 93%

Exercise‐induced irisin release as a determinant of the metabolic response to exercise training in obese youth: the EXIT trial

et al. 2017

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The mechanisms underlying the metabolic improvements following aerobic exercise training remain poorly understood. The primary aim of this study was to determine if an adipomyokine, irisin, responded to acute exercise was associated with the metabolic adaptations to chronic aerobic exercise in obese youth. The acute response to exercise was assessed in 11 obese youth following 45‐min acute bouts of aerobic (AE) and resistance exercise (RE). The irisin area under the curve (pre‐exercise, 15, 30, and 45 min) during these AE sessions were the main exposure variables. The primary outcome measure was the change in insulin sensitivity using the Matsuda index, following 6 weeks of RE training, delivered for 45 min, three times per week at 60–65% 1RM. Participants were also categorized as either responders (above) or nonresponders (below) based on the percentage change in the Matsuda index following the 6‐week intervention. Irisin increased significantly during the acute bout of AE from 29.23 ± 6.96 to 39.30 ± 7.05 ng/mL; P = 0.028, but not significantly during the RE session (P = 0.182). Absolute and relative change in irisin during the acute bout of AE was associated with absolute and relative change in Matsuda index (r = 0.68; P = 0.022 and r = 0.63; P = 0.037) following the 6‐week RE intervention. No such association was observed with the irisin response to acute RE (all P > 0.05). Responders to the 6‐week RE intervention displayed a fourfold greater irisin response to acute AE (90.0 ± 28.0% vs. 22.8 ± 18.7%; P = 0.024) compared to nonresponders. Irisin increases significantly following an acute bout of AE, but not RE, and this response is associated with a greater improvement in insulin sensitivity in response to chronic resistance training.

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Section: Discussionsupporting

confidence: 93%

Exercise‐induced irisin release as a determinant of the metabolic response to exercise training in obese youth: the EXIT trial

et al. 2017

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“…Another study reported that the changes in serum levels of irisin are associated with post-exercise duration, with a rising trend following single sessions of endurance exercise and strength training, then after the peak value gradually declined until 24 h [42]. In addition, a recent metaanalysis concluded that fitness level and BMI were identified as important predictive variables for post-exercise irisin concentration [43]. In contrast, a few studies showed that neither acute nor chronic exercise had any influence on FNDC5 and irisin levels in overweight and obese people [44].…”

Section: Irisin and Exercisementioning

confidence: 99%

Physical Exercise as Therapy for Type 2 Diabetes Mellitus: From Mechanism to Orientation

Yang

et al. 2019

Ann Nutr Metab

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Background: Exercise therapy plays an important role in the prevention and treatment of type 2 diabetes (T2DM). The mechanism of exercise therapy in the improvement of glycolipid metabolism of T2DM is very complex and not completely clear. Summary: Exercise training improves the whole body metabolic health in patients with T2DM, leading to an increase in glycolipid uptake and utilization, improved insulin sensitivity, optimized body mass index, and modulated DNA methylation, etc. Recent findings support that some cytokines such as irisin, osteocalcin, and adiponectin are closely related to exercise and metabolic diseases. This study briefly reviews the physiological mechanisms of exercise therapy in diabetes and the potential role of these cytokines in exercise. Key Messages: More high-quality, targeted, randomized controlled studies are needed urgently, from mechanism study to treatment direction, to provide a more theoretical basis for exercise therapy and to explore new therapeutic targets for diabetes.

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“…Conversely, sprint training for 4 weeks significantly decreased the resting serum irisin concentration in healthy males [ 14 ]. Recently, Fox et al, using a single and multiple meta-regressions, suggested that an acute bout of exercise was accompanied by a post-exercise average increase in irisin concentration of 15% [ 15 ]. Therefore, the objective of this study was to compare the effect of one bout of aerobic exercise of moderate intensity and HIIT exercise on irisin levels in skeletal muscle and plasma of sedentary adolescent girls who were overweight or obese.…”

Section: Introductionmentioning

confidence: 99%

Muscle irisin response to aerobic vs HIIT in overweight female adolescents

Archundia-Herrera

Macías-Cervantes

Ruiz-Muñoz

et al. 2017

Diabetol Metab Syndr

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BackgroundExercise stimulates the production of fibronectin type III domain-containing protein 5 (FNDC5), which is cleaved to release a protein called irisin. This protein induces browning of white adipose tissue resulting in increased thermogenesis. Different studies have measured circulating irisin at baseline and in response to exercise among a wide variety of individuals; yet, regarding the effect of different exercise intensities in obese adolescent girls, limited insight is available. This study compares the effect of acute aerobic exercise of moderate intensity and high-intensity interval training (HIIT) on irisin levels in skeletal muscle and plasma of sedentary overweight or obese female adolescents.MethodsThe aerobic group (n = 15) and HIIT group (n = 15) underwent anthropometric and metabolic measurements, electrocardiogram, peak oxygen uptake (VO2peak), and two vastus lateralis muscle biopsies before and after session of workout. The session of aerobic exercise included cycling at 65% of their peak heart rate (HRpeak) for 40 min. In the HIIT group, exercise included six bouts of 1 min at 85–95% HRpeak separated by 1 min of recovery. Irisin levels were evaluated in samples of skeletal muscle (western blot) and plasma (ELISA).ResultsThe levels of expression of irisin in skeletal muscle increased significantly after a session of HIIT (p < 0.05), while aerobic exercise no affect irisin levels. No significant differences between the groups in plasma irisin levels were found.ConclusionsThe increase in muscle irisin levels was observed only following HIIT session. No increases in plasma irisin concentration were observed.

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Effect of an acute exercise bout on immediate post‐exercise irisin concentration in adults: A meta‐analysis

Cited by 115 publications

References 52 publications

Exercise‐induced irisin release as a determinant of the metabolic response to exercise training in obese youth: the EXIT trial

Exercise‐induced irisin release as a determinant of the metabolic response to exercise training in obese youth: the EXIT trial

Physical Exercise as Therapy for Type 2 Diabetes Mellitus: From Mechanism to Orientation

Muscle irisin response to aerobic vs HIIT in overweight female adolescents

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