Effect of an Acute Bout of Endurance Exercise on Serum 25(OH)D Concentrations in Young Adults

Sun, Xiaomin; Cao, Zhen-Bo; Taniguchi, Hirokazu; Tanisawa, Kumpei; Higuchi, Mitsuru

doi:10.1210/jc.2017-00146

Cited by 48 publications

(65 citation statements)

References 32 publications

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“…After selection of supporting evidence, we found that aerobic exercise could successfully induce a variety of metabolic activities, which adjusted serum vitamin D into an optimal level (44). At the same time, studies in Japan found that endurance training suppressed a seasonal decrease in serum 25(OH)D concentrations (45). Studies have reported that smoking has a strong association with vitamin D deficiency in non-small cell lung cancer (46).…”

Section: Discussionmentioning

confidence: 98%

Association of Circulating 25-Hydroxyvitamin D Levels with Colorectal Cancer: An Updated Meta-Analysis

Yuan

et al. 2018

J Nutr Sci Vitaminol

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A higher serum 25-hydroxyvitamin D (25(OH)D) concentration benefits colorectal cancer prevention. However, whether it can improve the prognosis among patients is still under discussion. This study aims to explore the impacts of high level 25(OH)D on the survival of colorectal cancer patients. PubMed, Embase, and Cochrane were searched from January 2000 to August 2017 for relevant articles. Only published studies focusing on the relationship between 25(OH)D levels at or near the time of diagnosis and survival were considered. Two review authors independently assessed the risk of bias for each study, and any disagreement was resolved by discussion or by involving a third assessor. Eleven studies comprising 7,367 patients were included. In these studies, there were considerable differences between the higher 25(OH)D level group and the lower group in terms of overall survival (OS), progression-free survival (PFS) and colorectal cancer-specific survival (CSS) in a random effect model (OS: HR 0.67, 95% CI 0.56-0.80, p,0.00001; CSS: HR 0.73, 95% CI 0.55-0.97, p50.03; PFS: HR 0.74, 95% CI 0.61-0.90, p50.003). Moreover, the combined hazard ratios of OS and CSS had considerably significant heterogeneity which may be explained by subgroup analysis. The relationship between 25(OH)D and tumor characteristics/lifestyle factors was also included in the meta-analysis. BMI (p50.03), smoking (p50.03) and physical activity (p50.002) seemed to be associated with circulating 25(OH)D level. Publication bias was undetected. Colorectal cancer patients with higher circulating 25(OH)D level may have a better prognosis.

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Section: Discussionmentioning

confidence: 98%

Association of Circulating 25-Hydroxyvitamin D Levels with Colorectal Cancer: An Updated Meta-Analysis

Yuan

et al. 2018

J Nutr Sci Vitaminol

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“…Dietary vitamin D intake was controlled, there was no weight loss, and confounding from sunlight exposure was mitigated by the dogs' thick fur coats (How et al 1994). Furthermore, Sun et al (2017) showed elevated serum 25 (OH)D concentrations in lean humans in response to 30 minutes of cycling exercise at 70% _ VO 2 peak (Fig. 2a,b).…”

Section: Physical Activity/exercise and Vitamin D Statusmentioning

confidence: 89%

“…(a) The effect of 30 minutes of cycling exercise at 70%

\dot{normalV} {normalO}_{2} \max

on serum 25( OH )D concentrations in humans [redrawn using data from Sun et al . ()]. Data shown are mean ± standard error of the mean (SEM) for men and women combined.…”

Section: Physical Activity/exercise and Vitamin D Statusmentioning

confidence: 99%

“…Left‐hand bar represents change from pre‐exercise to immediately post‐exercise, right‐hand bar represents change from pre‐exercise to 24 hours post‐exercise [redrawn using data from Sun et al . ()]. (c) The effect of 5 weeks of progressive cycling endurance exercise (30 minute bouts, 3 bouts/week, from 60% to 75%

\dot{normalV} {normalO}_{2} peak

) during winter months on serum 25( OH )D [redrawn using data from Sun et al .…”

Section: Physical Activity/exercise and Vitamin D Statusmentioning

confidence: 99%

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Mobilising vitamin D from adipose tissue: The potential impact of exercise

et al. 2019

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Vitamin D is lipophilic and accumulates substantially in adipose tissue. Even without supplementation, the amount of vitamin D in the adipose of a typical adult is equivalent to several months of the daily reference nutrient intake (RNI). Paradoxically, despite the large amounts of vitamin D located in adipose tissue, individuals with obesity are often vitamin D deficient according to consensus measures of vitamin D status (serum 25‐hydroxyvitamin D concentrations). Thus, it appears that vitamin D can become ‘trapped’ in adipose tissue, potentially due to insufficient lipolytic stimulation and/or due to tissue dysfunction/adaptation resulting from adipose expansion. Emerging evidence suggests that exercise may mobilise vitamin D from adipose (even in the absence of weight loss). If exercise helps to mobilise vitamin D from adipose tissue, then this could have important ramifications for practitioners and policymakers regarding the management of low circulating levels of vitamin D, as well as chronically low levels of physical activity, obesity and associated health conditions. This perspective led us to design a study to examine the impact of exercise on vitamin D status, vitamin D turnover and adipose tissue vitamin D content (the VitaDEx project). The VitaDEx project will determine whether increasing physical activity (via exercise) represents a potentially useful strategy to mobilise vitamin D from adipose tissue.

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“…One limitation of the current study is that we only measured two metabolites of vitamin D. [24]. Further, the effect of exercise on the osteoblast and osteoclast metabolism, in addition to the direct effect of loading, is also modi ed by myokines, such as IL-6, IGF-1, FGF2, and others [25, [26].…”

Section: Strengths and Limitations Of The Studymentioning

confidence: 99%

Serum Levels of Bone Formation and Resorption Markers in Relation to Vitamin D Status in Professional Athletes and Physically Active Men During Upper and Lower Body High-intensity Exercise

Mieszkowski

Kochanowicz

Piskorska

et al. 2020

Preprint

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Purpose/Introduction: To compare serum levels of bone turnover markers in athletes and non-athletes, and to evaluate the relationship between serum levels of vitamin D metabolites and exercise-induced changes in biomarker levels. Methods: Sixteen elite male artistic gymnasts (EG; 21.4 ± 0.8 years-old) and 16 physically active men (the control group, PAM; 20.9 ± 1.2 years-old) performed lower and upper body 30-s Wingate anaerobic tests (LBWT and UBWT, respectively). For biomarker analysis, blood samples were collected before, and 5 and 30 min after exercise. Samples for vitamin D levels were collected before exercise. N-terminal propeptide of type I collagen (PINP) was analysed as a marker of bone formation. C-terminal telopeptide of type I collagen (CTX) was analysed as a marker of bone resorption.Results: UBWT fitness readings were better in the EG group than in the PAM group, with no difference in LBWT readings between the groups. UBWT mean power was 8.8% higher in subjects with 25(OH)D3 levels over 22.50 ng/ml and in those with 24,25(OH)2D3 levels over 1.27 ng/ml. Serum CTX levels increased after both tests in the PAM group, with no change in the EG group. PINP levels did not change in either group; however, in PAM subjects with 25(OH)D3 levels above the median, they were higher than those in EG subjects. Conclusion: Vitamin D metabolites affect the anaerobic performance and bone turnover markers at rest and after exercise. Further, adaptation to physical activity modulates the effect of anaerobic exercise on bone metabolism markers.

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Effect of an Acute Bout of Endurance Exercise on Serum 25(OH)D Concentrations in Young Adults

Abstract: There is a direct effect of endurance exercise on serum 25(OH)D concentrations. In addition, sex disparity was observed in the serum 25(OH)D response to acute endurance exercise, and the increase in 25(OH)D concentrations was greater in men than in women.

Cited by 48 publications

References 32 publications

Association of Circulating 25-Hydroxyvitamin D Levels with Colorectal Cancer: An Updated Meta-Analysis

Association of Circulating 25-Hydroxyvitamin D Levels with Colorectal Cancer: An Updated Meta-Analysis

Mobilising vitamin D from adipose tissue: The potential impact of exercise

Serum Levels of Bone Formation and Resorption Markers in Relation to Vitamin D Status in Professional Athletes and Physically Active Men During Upper and Lower Body High-intensity Exercise

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