Effect of AMPK Subunit Alpha 2 Polymorphisms on Postherpetic Pain Susceptibility in Southwestern Han Chinese

Abstract

Introduction Adenosine 5’-monophosphate (AMP)-activated protein kinase (AMPK) can influence energy metabolism. Energy metabolism imbalance is closely associated with the occurrence of neuropathic pain (NeP). Rs10789038 and rs2796498 are genetic polymorphisms of PRKAA2 , the gene encoding AMPK, which is closely related to energy metabolism imbalance. This study aimed to explore the relationship between PRKAA2 and postherpetic neuralgia (PHN) in the southwestern Chinese Han population. Methods This study enrolled 132 PHN patients and 118 healthy subjects. The rs10789038 and rs2796498 PRKAA2 genotypes were identified in all participants. The association between these single nucleotide polymorphisms and PHN susceptibility was evaluated in the dominant and recessive models. Haplotype analysis of patients with PHN and healthy controls was performed. Results The PHN patients were older than the healthy subjects ( P < 0.05); however, the other clinical characteristics between two groups were not significantly different (all P >0.05). Genotypes and allele frequencies differed significantly between PHN patients and healthy subjects in the rs10789038 polymorphism ( P < 0.05), but not in rs2796498 ( P > 0.05). In addition, the GG haplotype of rs10789038-rs2796498 correlated negatively with PHN occurrence in haplotype analysis ( P < 0.05). Conclusion PHN occurrence may be related to the PRKAA2 rs10789038 A>G genetic polymorphism in the southwestern Chinese Han population.

Genetic polymorphisms of PRKAA1 (AMPKα1) and postherpetic pain susceptibility: Multicenter, randomized control, and haplotype analysis study

“…Postherpetic neuralgia (PHN) is the most common and serious complication after herpes zoster infection. It is a type of intractable neuropathic pain (NeP) that affects mental state and the daily life of patients in severe cases ( Mei et al, 2022 ). The incidence of PHN is approximately 5–30% in patients with herpes zoster ( Kawai et al, 2014 ).…”

“…However, there are few studies on the correlation between AMPK gene polymorphisms and gastric cancer, rectal cancer, diabetes mellitus and Hepatitis B virus infection ( Lee et al, 2014 ; Yuan et al, 2016 ; Chen et al, 2018 ; Jiang et al, 2018 ; Li et al, 2020 ). Our previous study identified that the PRKAA2 gene polymorphism had a significant effect on PHN susceptibility ( Mei et al, 2022 ). The purpose of this study was to explore the association between genetic polymorphisms in PRKAA1 and PHN in Chinese individuals.…”