Effect of amitriptyline on neurotransmitter levels in adult mice following infection with the avirulent strain of Semliki Forest virus

Mehta, Surekha; Parsons, Linda M.; Webb, H. E.

doi:10.1016/0022-510x(93)90096-h

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…Such non-destructive infection of neurons could affect neuronal function as has been observed with lymphocytic choriomeningitis virus (Lipkin et al, 1988). SFV A7(74) infection of immunocompetent mice has been reported to suppress levels of neurotransmitters including noradrenaline and adrenaline (Barrett et al, 1986;Mehta et al, 1993) which are important in controlling behaviour and mood. In the CNS of neonatal and suckling mice, SFV A7(74) infection is productive Fazakerley et al, 1993).…”

Section: Discussionmentioning

confidence: 98%

Role of immune responses in protection and pathogenesis during Semliki Forest virus encephalitis

Amor

Scallan

Morris

et al. 1996

Journal of General Virology

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The course of Semliki Forest virus (SFV) A7(74) infection in immunocompetent BALB/c, athymic nu/nu and severe combined immunodeficient (SCID) mice was compared. BALB/c mice remained healthy and exhibited transient viraemia and infectious virus in the brain from days 2 to 7. Antibodies were detectable by day 5. In comparison, SCID mice displayed a high incidence of paralysis and died: the average day of death was day 23.

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Section: Discussionmentioning

confidence: 98%

Role of immune responses in protection and pathogenesis during Semliki Forest virus encephalitis

Amor

Scallan

Morris

et al. 1996

Journal of General Virology

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“…Viruses may produce a latent infection that does not cause an immune response (Joly et al, 1991), may alter secretion of only one neurotransmitter (Oldstone, 1989), or may cause 'hit and run' infections in which long-lasting alterations of cellular function can occur after the virus has disappeared (Demitrack and Greden, 1991). A virally induced neurotransmitter deficit may be corrected with appropriate medication (Mehta et al, 1993). Latent herpesvirus infections are well known to exist in nerve ganglia and to appear at times of stress (Bonneau et al, 1993).…”

mentioning

confidence: 99%

Fibromyalgia syndrome: a pain modulation disorder related to altered limbic function?

Goldstein¹

1994

Baillière's Clinical Rheumatology

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publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. Fibromyalgia syndrome: a pain modulation disorder related to altered limbic function?JAY A. GOLDSTEIN As a physician who specializes in the diagnosis and treatment of chronic fatigue syndrome (CFS) and fibromyalgia syndrome (FMS), I see a large number of patients who also have such problems as irritable bowel syndrome, panic disorder, amnestic disorder, allergic rhinitis, blurred vision, muscle fasciculations, myasthenia, interstitial cystitis, sleep disorders, headache, bruxism, irritable bladder, alopecia, thermoregulatory dysfunction, lymphadenalgia, dyspnoea, chemical sensitivity, endometriosis, late luteal phase dysphoric disorder, heart palpitations, photophobia, vertigo, Raynaud phenomenon and dysmenorrhoea. Some patients have immune activation related to 'overlap syndromes' with such disorders as systemic lupus erythematosus and multiple sclerosis. Over half report feeling well until they had 'the worst flu of my life', after which they never felt the same, so that investigation of persistent viral infection or 'hit and run' viral episodes that result in long-term functional impairment of affected and bystander cells is relevant.It is quite common for me to consult with individuals who have many of the above disorders. Initially, most of them seemed unrelated. Looking for a mechanism to produce such a wide range of illnesses led me to the study of neuroimmunoendocrine networks, especially the limbic system and its projections. This myriad of signs and symptoms may be explained by limbic dysfunction.The literature discussing the structure and function of the limbic system and its cortical projections (Figure 1), an example of a neural network which uses a parallel distributed computational strategy, is complex and may be unfamiliar to many readers of this volume. These topics have been well discussed by M. -Marsel Mesulam (1985, and these works form a good foundation for the understanding of limbic physiology and its derangements.One can view the limbic neural network functioning as a computer, processing intero-and exteroceptive stimuli (input), primarily via a bewildering array of chemically transduced messages, integrating them with experiences and attitudes (processing), and selecting responses (output) that should ideally maximize the survival capabilities of the individual (Figure 2).

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Behavioral Abnormalities and Disease Caused by Viral Infections of the Central Nervous System

Hatalski¹,

Lipkin²

1997

Parasites and Pathogens

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Effect of amitriptyline on neurotransmitter levels in adult mice following infection with the avirulent strain of Semliki Forest virus

Cited by 6 publications

References 23 publications

Role of immune responses in protection and pathogenesis during Semliki Forest virus encephalitis

Role of immune responses in protection and pathogenesis during Semliki Forest virus encephalitis

Fibromyalgia syndrome: a pain modulation disorder related to altered limbic function?

Behavioral Abnormalities and Disease Caused by Viral Infections of the Central Nervous System

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