Abstract:The effect of different amine uptake inhibitors on the accumulationof 14C-bretyliuminsympathetically denervated or decentralized salivary glands were studied in vivo in rats 11-14 hours after the surgical intervention. The time period chosen is known to be critical for the delaying effect of bretylium on the degeneration transmitter release in sympathetically innervated organs. Cocaine, desmethylimipramine (DMI), protriptyline or reserpine all depressed the uptake of ''C-bretylium in both denervated and decent… Show more
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