Effect of Ambient Air Pollution on Infant Bronchiolitis

Karr, Catherine; Kaufman, Joel D.; Lumley, Thomas; Davis, Robert N.; Shepherd, Kristen; Ritz, Beate; Larson, Timothy V.

doi:10.1097/00001648-200407000-00068

Cited by 2 publications

(6 citation statements)

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“…2 ). Two studies ( Karr et al, 2004 , 2006 ) found no increased risk of hospitalisation with acute exposure to PM2.5. Sub-chronic effects are unclear, but lifetime exposure may increase risk of hospitalisation ( Fig.…”

Section: Resultsmentioning

confidence: 96%

“…3 ). Two studies found no increased risk of acute exposure ( Karr et al, 2004 , 2006 ), and one found a statistically significant association at a lag of 0–4 days (OR 1.04 [1.02–1.07]), but not 0–1 days ( Segala et al, 2008 ). Three studies ( Abdul Rahman et al, 2017 ; Karr et al, 2007 , 2009b ) found no association with risk of hospitalisation admission, but one ( Karr et al, 2009a ) found statistically significant association with sub-chronic (OR 1.11 [1.08–1.14]) and lifetime exposure (OR 1.12 [1.09–1.16]).…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies (including four case control studies and four case crossover studies Abdul Rahman et al, 2017 ; Girguis et al, 2017 ; Karr et al, 2004 , 2006 , 2007 , 2009a , 2009b ; Segala et al, 2008 ) were eligible for our review. The review flowchart is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Six of the studies were from overlapping research groups in North America ( Girguis et al, 2017 ; Karr et al, 2004 , 2006 , 2007 , 2009a , 2009b ), one from France ( Segala et al, 2008 ) and one from Malaysia ( Abdul Rahman et al, 2017 ) a developing country. The study characteristics are summarised in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

“…Based on low-quality evidence from two studies ( Karr et al, 2004 , 2006 ), CO does not seem to have acute effects on the risk of hospitalisation for bronchiolitis ( Fig. 3 ).…”

Section: Resultsmentioning

confidence: 99%

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The effect of outdoor air pollution on the risk of hospitalisation for bronchiolitis in infants: a systematic review

King

Kirkham

Hawcutt

et al. 2018

PeerJ

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ObjectiveTo systematically review the evidence around the effect of ambient levels of particulate and gaseous pollutants, and the risk of hospitalisation with bronchiolitis for infants under two years of age.DesignSystematic review of observational epidemiological studies including cohort, time series, case crossover and case control study designs.Data sourcesMedline, Scopus, and Web of Science searched to November 2017 with no language restrictions.Eligibility criteriaStudies investigating impact of air pollution levels on particulate pollutants (diameter <2.5 μm (PM2.5) or <10 μm (PM10) and gaseous pollutants (nitrogen dioxide (NO2), sulphur dioxide (SO2), carbon monoxide (CO), ozone (O3)) on hospital admission for bronchiolitis.Main outcome measureRisk of hospitalisation from bronchiolitis.ResultsEight studies were eligible for review. Long term exposure to PM2.5 may be associated with increased risk of hospitalisation for bronchiolitis. SO2 may also be associated with hospitalisation, but results for other pollutants are inconsistent between studies. In three of the five studies that showed a positive association between air pollutants and hospitalisation, measured concentrations were below World Health Organization (WHO) recommended levels.ConclusionsCertain particulate and gaseous pollutants may have a clinically relevant effect on hospital admissions for bronchiolitis in children below age two years old. Large cohort or time series studies are needed to examine this possible association.ProtocolThe protocol can be found at PROSPERO (CRD42017080643).

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Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Based on low-quality evidence from two studies ( Karr et al, 2004 , 2006 ), CO does not seem to have acute effects on the risk of hospitalisation for bronchiolitis ( Fig. 3 ).…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

The effect of outdoor air pollution on the risk of hospitalisation for bronchiolitis in infants: a systematic review

King

Kirkham

Hawcutt

et al. 2018

PeerJ

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Ambient PM2.5 and Daily Hospital Admissions for Acute Respiratory Infections: Effect Modification by Weight Status of Child

Nishikawa

Madaniyazi

et al. 2021

Atmosphere

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The high level of ambient particulate matter in many developing countries constitutes a major health burden, but evidence on its impact on children’s health is still limited in these regions. We conducted a time-stratified case-crossover analysis to quantify the short-term association between fine particulate matter (PM2.5) and hospital admissions due to acute respiratory infections (ARI) among children in Bhaktapur district, Nepal, and to investigate the potential modification of the effect by nutritional characteristic. We analyzed 258 children admitted to the pediatric hospital for ARI between February 2014 to February 2015. We observed evidence of increased risk on the same (lag 0) and preceding day (lag 1). The cumulative estimate of their average (lag 01) suggested each 10 μg/m3 increase in PM2.5 was associated with a relative risk (RR) of 1.16 (95% confidence interval [CI]: 1.02–1.31). The strongest evidence from a stratified analysis of three categories of weights was observed in the overweight group (RR: 1.77; 95% CI: 1.17–2.69) at lag 01, while the estimates for the normal weight and underweight groups were closer to the non-stratified estimates for all-ARI cases. The findings suggests that pediatric ARI is an important morbidity associated with inhalable PM2.5 and that more research is needed to elucidate and validate the observed dissimilarity by weight.

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Effect of Ambient Air Pollution on Infant Bronchiolitis

Cited by 2 publications

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The effect of outdoor air pollution on the risk of hospitalisation for bronchiolitis in infants: a systematic review

The effect of outdoor air pollution on the risk of hospitalisation for bronchiolitis in infants: a systematic review

Ambient PM2.5 and Daily Hospital Admissions for Acute Respiratory Infections: Effect Modification by Weight Status of Child

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