Effect of alprostadil in the treatment of intensive care unit patients with acute renal injury

Abstract

BACKGROUND Acute kidney injury (AKI) is a sudden or rapid decline in the filtration function of the kidneys which is marked by increased serum creatinine or blood urea nitrogen. AIM To examine the value of alprostadil-assisted continuous venous-venous hemofiltration (CVVH) in the treatment of severe AKI in severely ill patients. METHODS This was a retrospective study and the inclusion criteria were as follows: (1) Age of patients (≥ 18 years); (2) Admission to intensive care unit due to non-renal primary disease, APACHE II score (≥ 18 points); (3) The diagnostic criteria of AKI guidelines were formulated with reference to the Global Organization for the Improvement of Prognosis in Kidney Diseases, with AKI grades of II-III; (4) All patients were treated with CVVH; and (5) Complete basic data were obtained for all patients. RESULTS The clinical effect of alprostadil administered in the treatment group was better than that observed in the control group ( P < 0.05). The urine output of patients in the alprostadil group returned to normal time (9.1 ± 2.0 d) and was lower than that in the control group (10.6 ± 2.5 d), the difference was statistically significant ( P < 0.05); adverse reactions occurred in the alprostadil group compared with the control group, but the difference was not statistically significant ( P > 0.05). CONCLUSION Alprostadil-assisted CVVH in the treatment of severely ill patients with AKI can effectively improve the renal resistance index and partial pressure of urine oxygen, and has a positive effect on improving renal function.

Corticotrophins, corticosteroids, and prostaglandins

“…Each group received the medication once every 12 h for 1 week. Minor side effects of headache and dizziness were present in the group that took alprostadil ( Jia et al, 2021 ) [R].…”