Effect of Alpinia officinarum extract on reproductive damages in streptozotocin induced diabetic male rats

Heidari, Hadi; Abdollahi, Maasoume; Khani, Sima; Nojavan, Fatemeh; Khani, Samira

doi:10.1007/s40200-020-00711-0

Cited by 11 publications

(10 citation statements)

References 43 publications

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“…37 Another study demonstrated that hydroalcoholic extract of Alpinia officinarum can ameliorate the sperm parameters in STZ-induced diabetic rats, probably via its antioxidant components. 38 Roshankhah et al demonstrated the protective effects of the ADP hydroalcoholic extract against mercuric chloride-induced liver damage. They reported that treatment with ADP, due to its potent antioxidant properties, can result in decreased ROS, the activation of antioxidant factors and detoxification enzymes.…”

Section: Discussionmentioning

confidence: 99%

“…A study by Ahangarpour et al found that extract of applied burdock root has anti‐infertility effects via enhancement of sperm count, levels of testosterone and gonadotropin in nondiabetic mice 37 . Another study demonstrated that hydroalcoholic extract of Alpinia officinarum can ameliorate the sperm parameters in STZ‐ induced diabetic rats, probably via its antioxidant components 38 …”

Section: Discussionmentioning

confidence: 99%

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The antioxidant effects of hydroalcoholic extract of Ashrasi date palm on sperm parameters and DNA fragmentation in diabetic rats

Hosseinipour

Asgari

Kermani

et al. 2022

Anim Models and Exp Med

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Diabetes is a metabolic disorder in which the blood glucose level is increased because of a lack of insulin production or a reduction in insulin sensitivity and function. 1 Diabetes causes injury to different organs and leads to their dysfunctions and failures. 2 One of the complications of diabetes can be disruption of reproductive system of men. 3 The metabolism of glucose is a key factor during

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The antioxidant effects of hydroalcoholic extract of Ashrasi date palm on sperm parameters and DNA fragmentation in diabetic rats

Hosseinipour

Asgari

Kermani

et al. 2022

Anim Models and Exp Med

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“…Diabetic-induced reproductive dysfunction is a common diabetic complication, which can lead to low fertility and/or infertility in male DM patients. Long-term hyperglycemia resulted in severe testicular histological damage, including morphological destruction of seminiferous tubules and impaired spermatogenesis, and increased testicular oxidative stress and apoptosis. , Few studies on the use of flavonoids were available, especially Hst, for the treatment of diabetic reproductive damages. Samie et al conducted animal experiments, and the results of which showed that in addition to improvement of serum glucose and testosterone levels, strengthening the antioxidant system of the testis, weakening the inflammation index of the testis, and preventing damage to the seminiferous tubules were also shown in the Hst-treated diabetic rats (100 mg/kg).…”

Section: Therapeutic Mechanisms Of Hesperetin On Diabetes and Related...mentioning

confidence: 99%

Hesperetin, a Promising Treatment Option for Diabetes and Related Complications: A Literature Review

Yang

Wang

et al. 2022

J. Agric. Food Chem.

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The morbidity and mortality of diabetes have increased dramatically in recent decades. Novel strategies for treating diabetes and its complications with minimal side effects are in urgent need. New monomeric molecules extracted from herbal medicine, which is a form of alternative medicine, are being sought as drug candidates for the treatment of diabetes and its complications. Hesperetin (Hst), a citrus flavonoid, is of increasing interest in scientific studies recently due to its properties in combating diabetes and its complications, whereas existing studies are scattered and unsystematic. Here, we summarized the literature studies over the last 10 years to review the potential therapeutic role of Hst in the prevention and mitigation of diabetes and its complications, intending to provide promising strategies for the clinical management of diabetes and its complications.

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“…Alpinia officinarum extract was reported to improve sperm parameters and histological damage in testis of the diabetic rats (7) .…”

Section: Introductionmentioning

confidence: 98%

Effect of Alpinia Officinarum Rhizome Extract on Fertility and Sexual Behavior of Adult Male Albino Rats Treated with Sotalol

Bebars

Habeby

Issa

et al. 2021

The Egyptian Journal of Hospital Medicine

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Background: Infertility in cardiovascular patients is not only attributed to pathogenesis of the disease but, also to the used therapeutic drugs. Beta blockers which are corner stone in treatment of these patients are reported to affect fertility and sexual behavior in patients using them. Alpinia officinarum (A. officinarum) rhizome extracts are widely used for their antioxidant and anti-inflammatory effects to improve oxidative stress which affects organs due to using different drugs or pathogenesis of different diseases. Objective: The current work aimed to study effect of Alpinia officinarum rhizome extract on improving the reproductive function and sexual behavior of adult male Albino rat treated with Sotalol. Materials and Methods: Fifty adult male Albino rats were categorized into five groups. Group I control, group II (A. officinarum group) received A. officinarum extract at a dose of 200mg/kg/day in olive oil orally by gastric tube for 21 days, group III (Sotalol group) received Sotalol at a dose of 3mg/kg/day orally by gastric tube for 21 days, group IV (protected group) received the extract then Sotalol and group V (treated group) received Sotalol then the extract. Then fifty adult female rats were used for assessment of sexual behavior through observing mount latency and frequency. Results: Sotalol induced testicular destruction in the form of shedding of germinal epithelium, hyaline deposition, decreased sperm count with decreased testosterone level, increased oxidative stress in the form of decreased Serum superoxide dismutase (SOD) level and increased Serum malondialdehyde (MDA) level. Deterioration of sexual behavior in the form of increased mount latency and decreased mount frequency was noticed in the Sotalol group. A. officinarum extract produced a great preservation of testicular structure and sexual behavior in the protected group (IV) together with improvement in the treated group (V). Conclusion: Sotalol induced destructive effects on the testicular structure, function and sexual behavior which were greatly improved by using A. officinarum extract.

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Effect of Alpinia officinarum extract on reproductive damages in streptozotocin induced diabetic male rats

Cited by 11 publications

References 43 publications

The antioxidant effects of hydroalcoholic extract of Ashrasi date palm on sperm parameters and DNA fragmentation in diabetic rats

The antioxidant effects of hydroalcoholic extract of Ashrasi date palm on sperm parameters and DNA fragmentation in diabetic rats

Hesperetin, a Promising Treatment Option for Diabetes and Related Complications: A Literature Review

Effect of Alpinia Officinarum Rhizome Extract on Fertility and Sexual Behavior of Adult Male Albino Rats Treated with Sotalol

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