Effect of Alpha Tocopherol in Diabetes Mellitus

Vogelsang, Arthur

doi:10.1210/jcem-8-10-883

Cited by 6 publications

(3 citation statements)

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“…The effect of vitamin E supplementation on GRb may be explained by either of two mechanisms. First, the effect of vitamin E could be due both on insulin sensitivity, improved utilization of glucose and improved circulation [2,3]. Second, vitamin E could inhibit free radical production which might otherwise promote glycation [9,10].…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin E has been thought to improve the metabolism of glucose by muscle cells and blood circulation to the islets of Langerhans and other tissues [2,3]. Different clinical trials in Type IT diabetic patients have shown that supplementation with pharmacological doses of vitamin E (900-2000 ill/day) for a duration of 2-4 months results in both a decrease [4,5] and no effect [6] on blood GHb; a decrease [7] and no effect on blood glucose [4][5][6]; a decrease [4,5,7] and no effect [6] on TG; and a lower LDL oxidizability [6] compared with placebo treatments.…”

Section: Introductionmentioning

confidence: 99%

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Effect of modest vitamin E supplementation on blood glycated hemoglobin and triglyceride levels and red cell indices in type I diabetic patients.

Jain

McVie

Jaramillo

et al. 1996

Journal of the American College of Nutrition

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of modest vitamin E supplementation on blood glycated hemoglobin and triglyceride levels and red cell indices in type I diabetic patients.

Jain

McVie

Jaramillo

et al. 1996

Journal of the American College of Nutrition

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“…CONCLUSIONS -Various studies have suggested that vitamin E may improve the metabolism of glucose by muscle cells and the circulation to the islets of Langerhans and other tissues (43,44). Different clinical trials in type 2 diabetic patients have shown that supplementation with vitamin E (100-2,000 IU/day) for a duration of 2-4 months results in either a decrease (45)(46)(47) or no effect (48,49) on blood HbA 1c levels, a decrease (50) or no effect (45-48) on blood glucose levels, decreased (45)(46)(47)50) or no effect (48) on triglyceride levels, lower plasma malondialdehyde concentrations (51), and reduced LDL oxidizability (48,49) compared with placebo treatments.…”

Section: Figure 1-relationship Between Vitamin E (␣-Tocopherol) and Gmentioning

confidence: 99%

Vitamin E supplementation restores glutathione and malondialdehyde to normal concentrations in erythrocytes of type 1 diabetic children.

2000

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OBJECTIVE -This study examined the relationship between cellular glutathione and vitamin E concentrations and the effect of vitamin E (␣-tocopherol) supplementation on glutathione and lipid peroxidation product concentrations in the erythrocytes of type 1 diabetic patients.RESEARCH DESIGN AND METHODS -We obtained written informed consent to participate in this study from diabetic patients (n = 29) and their age-matched nondiabetic siblings (n = 21) according to the guidelines of the Institutional Review Board on Human Experimentation. Diabetic patients were supplemented with a DL-␣-tocopherol (vitamin E) capsule (100 IU/ orally) or placebo for 3 months in a double-blind clinical trial. Fasting blood samples were collected from each diabetic patient before the start of and after the 3 months of vitamin E or placebo supplementation. Glutathione, malondialdehyde (which is a product of lipid peroxidation), and ␣-tocopherol were determined using high-performance liquid chromatography. A total of 5 diabetic patients were excluded after randomization from the data analyses. Data were analyzed statistically using a paired Student' s t test to compare 12 diabetic patients taking vitamin E with 12 diabetic patients receiving placebo supplementation and to compare diabetic patients with healthy nondiabetic subjects.RESULTS -Erythrocytes of diabetic patients had 21% higher (P Ͻ 0.001) malondialdehyde and 15% lower (P Ͻ 0.05) glutathione concentrations than healthy subjects. Vitamin E in erythrocytes had a significant correlation with the glutathione concentrations in the erythrocytes (r = 0.46, P Ͻ 0.02). Vitamin E supplementation increased glutathione concentrations by 9% (P Ͻ 0.01) and lowered concentrations of malondialdehyde by 23% (P Ͻ 0.001) and of HbA 1c by 16% (P Ͻ 0.02) in erythrocytes of diabetic patients. No differences were evident in these parameters before versus after placebo supplementation.CONCLUSIONS -Glutathione level is significantly related to vitamin E level, and supplementation with vitamin E (100 IU/day) significantly increases glutathione and lowers lipid peroxidation and HbA 1c concentrations in the erythrocytes of type 1 diabetic patients.

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Symptomatologie und Therapie der E-Avitaminose

Jürgens

1952

Die Ernährung

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Effect of Alpha Tocopherol in Diabetes Mellitus

Cited by 6 publications

References 0 publications

Effect of modest vitamin E supplementation on blood glycated hemoglobin and triglyceride levels and red cell indices in type I diabetic patients.

Effect of modest vitamin E supplementation on blood glycated hemoglobin and triglyceride levels and red cell indices in type I diabetic patients.

Vitamin E supplementation restores glutathione and malondialdehyde to normal concentrations in erythrocytes of type 1 diabetic children.

Symptomatologie und Therapie der E-Avitaminose

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