Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study

Aslfalah, Hadise; Jamilian, Mehri; Ansarihadipour, Hadi; Abdollahi, Mahdi; Khosrowbeygi, Ali

doi:10.18502/ijrm.v18i12.8024

Cited by 4 publications

(4 citation statements)

References 25 publications

(19 reference statements)

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“…Overall, these data represent the first evidence that Myo is able to improve endothelial stress/damage in vascular cells by modulating inflammation and oxidative stress related to diabetes. These effects are comparable to the protective vascular action of LA, a molecule with well-known antioxidant effects that has demonstrated safety as well as beneficial effects on glycemia and liver enzymes as well as on lipid profiles and on adiponectin/leptin ratios in women affected by either GDM or polycystic ovary syndrome [ 8 , 27 , 30 , 31 , 32 , 33 ].…”

Section: Discussionmentioning

confidence: 96%

Myoinositol Reduces Inflammation and Oxidative Stress in Human Endothelial Cells Exposed In Vivo to Chronic Hyperglycemia

et al. 2021

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Myo-inositol (Myo) improves insulin resistance, glucose metabolism, and helps gestational diabetes (GDM) management. GDM is associated with a pro-inflammatory state and increased oxidative stress, which are both involved in vascular damage in diabetes. Our aim was to study Myo anti-inflammatory/antioxidant potential effects on an in vitro model of human umbilical vein endothelial cells (HUVECs). To this end, monocyte cell adhesion to HUVECs, adhesion molecule membrane exposure, and oxidative stress levels were determined in cells from control (C-) and GDM women treated during pregnancy either with diet only (GD-) or with diet plus Myo (GD+Myo). To deeply study the vascular effects of Myo, the same evaluations were performed in C- and GD-HUVECs following 48 h in vitro stimulation with Myo. Notably, we first observed that GD-HUVECs obtained from women assuming Myo supplementation exhibited a significantly decreased number of monocytes that adhered to endothelial cells, less adhesion molecule exposure, and lower intracellular reactive oxygen species (ROS) levels in the basal state as compared to GD-HUVECs obtained from women treated by diet only. This Myo anti-inflammatory/antioxidant effect was confirmed by 48 h in vitro stimulation of GD-HUVECs as compared to controls. Altogether, these results strongly suggest that Myo may exert protective actions against chronic inflammation induced by endothelial dysfunction in diabetes.

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Section: Discussionmentioning

confidence: 96%

Myoinositol Reduces Inflammation and Oxidative Stress in Human Endothelial Cells Exposed In Vivo to Chronic Hyperglycemia

et al. 2021

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“…Finally, a very- or low-GRADE quality score for most outcomes (supplements: FPG and PPG; diet: FPG, PPG, and HbA1c; exercise: PPG, HbA1c, and HOMA-IR) due to limitations in the design of included studies (e.g., allocation concealment, lack of blinding of either outcome assessors or participants, reporting of adherence to the intervention) could explain the lack of difference between intervention and control. The strengths of this review should be noted, as far as we know, this is the first SRMA that shows the benefits of supplement-, dietary-, and exercise-based interventions on measures of glycemic control in GDM, including more recent studies not included by the preceding SRMAs [ 26 , 28 , 31 , 42 , 51 ]. Overall this SRMA included a large number of participants with varied backgrounds and examines the effectiveness of lifestyle interventions on maternal glycemic control, ultimately reducing the risk of adverse perinatal outcomes.…”

Section: Discussionmentioning

confidence: 99%

Nutritional and Exercise-Focused Lifestyle Interventions and Glycemic Control in Women with Diabetes in Pregnancy: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

et al. 2023

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Diabetes disrupts one in six pregnancies, bestowing immediate and long-term health risks to mother and child. Diet and exercise are commonly prescribed to control dysglycemia, but their effectiveness across sub-populations and types of diabetes (type-1; type-2; or gestational diabetes mellitus, GDM) is uncertain. Therefore, a systematic review and meta-analysis on the effect of diet and/or exercise on glycemia in pregnant women with diabetes was conducted. Random effects models were used to evaluate effect sizes across studies and anticipated confounders (e.g., age, ethnicity, BMI). Of the 4845 records retrieved, 26 studies (8 nutritional supplements, 12 dietary, and 6 exercise interventions) were included. All studies were conducted in patients with GDM. Overall, supplement- and exercise-based interventions reduced fasting glucose (−0.30 mmol/L; 95% CI = −0.55, −0.06; p = 0.02; and 0.10 mmol/L; 95% CI = −0.20, −0.01; p = 0.04); and supplement- and diet-based interventions reduced HOMA-IR (−0.40; 95% CI = −0.58, −0.22; p < 0.001; and −1.15; 95% CI = −2.12, −0.17; p = 0.02). Subgroup analysis by confounders only confirmed marginal changed effect sizes. Our results suggest a favorable role of certain nutritional supplements, diet, and exercise practices on glycemia in women with GDM and underline a lack of evidence in ~20% of other diabetes-related pregnancies (i.e., women with pre-existing diabetes).

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“…There is a clinical trial study which reported the curative effect of ALA in GDM pregnancies. In this study, women with GDM showed a significant decrease in the maternal circulating values of triglyceride-glucose index, triglyceride (TG), TG/high-density lipoprotein cholesterol, atherogenic index of plasma, and thiobarbituric acid-reactive substances in the ALA group compared to the placebo group at the end of the intervention [ 93 ].…”

Section: Antioxidantsmentioning

confidence: 99%

Effect of Endogenic and Exogenic Oxidative Stress Triggers on Adverse Pregnancy Outcomes: Preeclampsia, Fetal Growth Restriction, Gestational Diabetes Mellitus and Preterm Birth

Joo

Kim

et al. 2021

IJMS

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Oxidative stress is caused by an imbalance between the production of reactive oxygen species (ROS) in cells and tissues and the ability of a biological system to detoxify them. During a normal pregnancy, oxidative stress increases the normal systemic inflammatory response and is usually well-controlled by the balanced body mechanism of the detoxification of anti-oxidative products. However, pregnancy is also a condition in which this adaptation and balance can be easily disrupted. Excessive ROS is detrimental and associated with many pregnancy complications, such as preeclampsia (PE), fetal growth restriction (FGR), gestational diabetes mellitus (GDM), and preterm birth (PTB), by damaging placentation. The placenta is a tissue rich in mitochondria that produces the majority of ROS, so it is important to maintain normal placental function and properly develop its vascular network to ensure a safe and healthy pregnancy. Antioxidants may ameliorate these diseases, and related research is progressing. This review aimed to determine the association between oxidative stress and adverse pregnancy outcomes, especially PE, FGR, GDM, and PTB, and explore how to overcome this oxidative stress in these unfavorable conditions.

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Effect of alpha-lipoic acid supplementation on the lipid profile and lipid ratios in women with gestational diabetes mellitus: A clinical trial study

Cited by 4 publications

References 25 publications

Myoinositol Reduces Inflammation and Oxidative Stress in Human Endothelial Cells Exposed In Vivo to Chronic Hyperglycemia

Myoinositol Reduces Inflammation and Oxidative Stress in Human Endothelial Cells Exposed In Vivo to Chronic Hyperglycemia

Nutritional and Exercise-Focused Lifestyle Interventions and Glycemic Control in Women with Diabetes in Pregnancy: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Effect of Endogenic and Exogenic Oxidative Stress Triggers on Adverse Pregnancy Outcomes: Preeclampsia, Fetal Growth Restriction, Gestational Diabetes Mellitus and Preterm Birth

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