Effect of Aloe vera Extract on Depression in People with Prediabetes

Foadoddini, Mohsen; Mofrad, Samaneh Alinejad

doi:10.5812/modernc.100927

Cited by 5 publications

(3 citation statements)

References 15 publications

(16 reference statements)

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“…After assessing the eligibility, 40 articles were excluded for some reasons: six articles were conducted not on humans, 13 articles involved another intervention, and 20 articles were not clinical trials. Thus, 13 articles were ultimately included in the meta-analysis (Alinejad-Mofrad et al, 2015;Ariska, 2019;Arora et al, 2009;Choi et al, 2013;Choudhary et al, 2014;Devaraj et al, 2013;Fallah Huseini et al, 2012;Foadoddini and Alinejad Mofrad, 2020;Huseini et al, 2012;Jubee et al, 2018;Malinti and Jael, 2019;Surya et al, 2020;Zarrintan et al, 2015) (Fig. 1).…”

Section: Results Of the Literature Searchmentioning

confidence: 99%

The effect of Aloe vera on fasting blood glucose levels in pre-diabetes and type 2 diabetes mellitus: A systematic review and meta-analysis

Budiastutik¹,

Subagio²,

Kartasurya³

et al. 2022

J Pharm Pharmacogn Res

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Context: Aloe vera is a traditional medicinal plant that shows a wide range of biological activities. Previous studies demonstrated the antihyperglycemic effect of Aloe vera but with inconsistent results. Aims: To quantitatively summarize the effect of Aloe vera on fasting blood glucose in pre-diabetes and type 2 diabetes mellitus by a meta-analysis. Methods: PubMed, Scopus, Springer Link, Science Direct, Proquest, and Google Scholar were used to identify clinical trials evaluating the effect of Aloe vera on fasting blood glucose published between 2011 and 2021. The inclusion criteria were: (1) original research with a clinical trial design evaluating the effect of Aloe vera on fasting blood glucose in pre-diabetes and/or type 2 diabetes mellitus; (2) providing the data of the mean fasting blood glucose and standard deviation in both control and intervention group, and; (3) Aloe vera was used as the only intervention. The pooled effect of Aloe vera on fasting blood glucose was evaluated using the random effect model, and publication bias was assessed by Funnel plots and Fail Safe-N. Results: A total of 25 trials were included from 13 publications involving 642 patients. The results showed that Aloe vera significantly reduced fasting blood glucose (-0.35 [95% CI, -1454, -0.616] mg/dL; p<0.001) compared to control. Aloe vera might have a more remarkable effect in males, BMI not more than 30 mg/kg2, type 2 diabetes mellitus, administered for ≥ 8 weeks, dose at 200 mg, and capsule administration. However, a high heterogeneity across the studies was found. Conclusions: Aloe vera may reduce fasting blood glucose in pre-diabetes and type 2 diabetes mellitus. However, further study with a well-design and standardized preparation is needed to emphasize the effect of Aloe vera on blood glucose control.

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Section: Results Of the Literature Searchmentioning

confidence: 99%

The effect of Aloe vera on fasting blood glucose levels in pre-diabetes and type 2 diabetes mellitus: A systematic review and meta-analysis

Budiastutik¹,

Subagio²,

Kartasurya³

et al. 2022

J Pharm Pharmacogn Res

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show abstract

“…In addition, Aloe vera may have a significant antidepressant effect. The intake of at least 500 mg of Aloe vera capsules reduced depressive state in patients after 8 weeks of treatment [ 190 ]. The concomitant use of fluoxetine, a selective serotonin reuptake inhibitor (SSRI), reduces depressant symptoms in a mouse model [ 191 ].…”

Section: Natural Compounds As An Alternative Treatment For Psoriasismentioning

confidence: 99%

Relationship between Immune Cells, Depression, Stress, and Psoriasis: Could the Use of Natural Products Be Helpful?

et al. 2022

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Psoriasis is one of the most widespread chronic inflammatory skin diseases, affecting about 2%–3% of the worldwide adult population. The pathogenesis of this disease is quite complex, but an interaction between genetic and environmental factors has been recognized with an essential modulation of inflammatory and immune responses in affected patients. Psoriatic plaques generally represent the clinical psoriatic feature resulting from an abnormal proliferation and differentiation of keratinocytes, which cause dermal hyperplasia, skin infiltration of immune cells, and increased capillarity. Some scientific pieces of evidence have reported that psychological stress may play a key role in psoriasis, and the disease itself may cause stress conditions in patients, thus reproducing a vicious cycle. The present review aims at examining immune cell involvement in psoriasis and the relationship of depression and stress in its pathogenesis and development. In addition, this review contains a focus on the possible use of natural products, thus pointing out their mechanism of action in order to counteract clinical and psychological symptoms.

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“…Diabetes mellitus is a chronic disease that has always been the primary health concern worldwide [1] . According to American Diabetes Association (ADA) and World Health Organization (WHO), diabetes mellitus is a metabolic disturbance characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both due to the pancreas' failure to produce insulin or insulin resistance [2,3] .…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic potential of Aloe vera in diabetes mellitus induced by diabetogenic substances and high fat diet: A systematic meta-analysis review

Hutapea¹,

Susanto²

2021

Int. J. Appl. Dent. Sci.

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Diabetes mellitus is a chronic disease that has always been the primary health concern worldwide. A few herbal plants showed anti-diabetic potential, Aloe is among these few species, and the pharmacological effects may vary for Aloe leaf preparations. We carried out a systematic and meta-analysis review to evaluate the hypoglycemics property of Aloe vera in Diabetes Mellitus Condition to develop its therapeutic benefit information and knowledge. The search used the following medical subject headings (MeSH): Aloe, aloe spp, diabetes mellitus, and hyperglycemia. This was followed by keyword search using Aloe vera or aloe gel or aloe polysaccharide or acemannan or aloe phytosterols or aloe elements. The historical search of relevant articles and personal contact with experts in the area were also undertaken. Twelve articles discuss the hypoglycemia effect of Aloe vera or Barbaloin or acemannan based in vivo study. Ten articles discuss the hypoglycemia effect of Aloe vera extract, and two articles discuss the hypoglycemia effect of the component of Aloe vera. In contrast, one article discusses the beneficial effect of polysaccharide equivalent Aloe vera gel on blood glucose levels in vivo and Yiman using Chromones based on Aloe vera. Several articles have been reviewed and concluded about the antidiabetic effect of Aloe vera on animal studies with the favorable properties and ability of this material, such as the antioxidant and anti-inflammatory ability.

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Effect of Aloe vera Extract on Depression in People with Prediabetes

Cited by 5 publications

References 15 publications

The effect of Aloe vera on fasting blood glucose levels in pre-diabetes and type 2 diabetes mellitus: A systematic review and meta-analysis

The effect of Aloe vera on fasting blood glucose levels in pre-diabetes and type 2 diabetes mellitus: A systematic review and meta-analysis

Relationship between Immune Cells, Depression, Stress, and Psoriasis: Could the Use of Natural Products Be Helpful?

Hypoglycemic potential of Aloe vera in diabetes mellitus induced by diabetogenic substances and high fat diet: A systematic meta-analysis review

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