Effect of allopurinol on lipid peroxidation induced in corporeal tissue by veno‐occlusive priapism in a rat model

Evliyaoğlu, Yalçın; Kayrın, Levent; Kaya, Bülent

doi:10.1046/j.1464-410x.1997.00371.x

Cited by 20 publications

(19 citation statements)

References 6 publications

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“…Our results support the observations of Evliyaoglu et al 30, 31 who previously demonstrated that there are increased levels of lipid peroxides in a veno-occlusive rat model of priapism. Interestingly, in the corpora of late stage-priapic sickle cell mice the levels of carbonylated residues decline relative to the priapic stage (Figure 5C).…”

Section: Discussionsupporting

confidence: 93%

“…There is increased awareness that oxidative stress in corporal tissue is a contributing factor to the development of ED 23–28, 29. Evliyaoglu et al 30, 31 have previously demonstrated that there are increased levels of lipid peroxides in a veno-occlusive rat model of priapism. In the present paper we describe changes in additional markers of oxidative stress in corporal tissue from two additional animal models (opiorphin induced priapism in the rat and a mouse model of sickle cell disease).…”

Section: Introductionmentioning

confidence: 99%

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Experimental priapism is associated with increased oxidative stress and activation of protein degradation pathways in corporal tissue

2010

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Priapism is a debilitating disease for which there is at present no clinically accepted pharmacologic intervention. It has been estimated that priapism lasting more than 24 hours in patients is associated with a 44–90% rate of erectile dysfunction (ED). In this investigation we determined in two animal models of priapism (opiorpin-induced priapism in the rat and priapism in a mouse model of sickle cell disease) if there is evidence for an increase in markers of oxidative stress in corporal tissue. In both animal models we demonstrate that priapism results in increased levels of lipid peroxidation, glutathione S-transferase activity, and oxidatively damaged proteins in corporal tissue. Using Western blot analysis we demonstrated there is up regulation of the ubiquitination ligase proteins, Nedd-4 and Mdm-2, and the lysososomal autophage protein, LC3. The anti-apoptotic protein, Bcl-2, was also up regulated. Overall, we demonstrate that priapism is associated with increased oxidative stress in corporal tissue and the activation of protein degradation pathways. Since oxidative stress is known to mediate the development of ED resulting from several etiologies (for example ED resulting from diabetes and aging) we suggest that damage to erectile tissue resulting from priapism might be prevented by treatments targeting oxidative stress.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Experimental priapism is associated with increased oxidative stress and activation of protein degradation pathways in corporal tissue

2010

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“…21 Thus, increased lipid peroxidation products (reactive oxygen species) and fibrogenic cytokines like TGF-b1 contributes to the triggering of the biochemical cascade that leads to cellular injury in ischemic state. 3,22 Nevertheless, when effective therapy for ischemic priapism is performed for increasing corporal partial pressure of oxygen, reperfusion causes erectile tissue injury owing to the presence of reactive oxygen species. Munarriz et al 23 in a rabbit model showed a significant increase in myeloperoxidase activity and lipid peroxidation after corporal reperfusion and demonstrated adhesion of the PMN leukocytes to the corporal endothelium and their infiltration to the underlying tissues.…”

Section: Histopathologic Changesmentioning

confidence: 99%

TGF-β1 neutralizing antibodies decrease the fibrotic effects of ischemic priapism

et al. 2004

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“…67 Mice lacking the genes for both neuronal and endothelial nitric oxide synthases display phasic erectile activity, indicating that the altered nitric oxide release affects the control mechanisms associated with penile erection. 68 After induction of prolonged erections or conditions of priapism in isolated cavernosal tissue experimentally in animals, the cavernosal tissue loses responsiveness to adrenergically stimulated tissue contraction, 69,70 undergoes destructive metabolism via lipid peroxidation, 71 and increases expression of the tissue fibrosis marker transforming growth factor beta. 72 …”

Section: Clinical Studymentioning

confidence: 99%

Priapism pathophysiology: clues to prevention

Burnett

2003

Int J Impot Res

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Priapism, in which penile erection persists in the absence of sexual excitation, is an enigmatic yet devastating erectile disorder. Current endeavors to manage the disorder suffer from a poor fundamental knowledge of the etiology and pathogenesis of priapism. These endeavors have remained essentially reactive, which commonly fail to avert its pathological consequences of erectile tissue damage and erectile disability, not to mention its psychological toll. The role of preventative management seems paramount with respect to priapism. As a prerequisite to formulating prevention strategies, gaining understanding of its pathogenic features and likely pathophysiologic mechanisms is viewed to be quite important. This review combined an analysis of clinicopathologic reports as well as a summary of clinical and basic science investigations on the subject to date. These assessments support the basic classification of priapism into low-flow (ischemic) and high-flow (nonischemic) hemodynamic categories, resulting from venous outflow occlusion and unregulated arterial overflow of the penis, respectively. In addition, consistent with the hypothesis that dysregulative physiology of penile erection accounts for some presentations of priapism, several plausible molecular mechanisms influencing the functional state of the erectile tissue are discussed. Current progress in the field suggests prevention possibilities using androgenic suppressive therapy, adrenergic agonist therapies, and effectors of the nitric oxide-dependent erection regulatory pathway in the penis. New ideas for prevention may emerge from targeting molecular mechanisms involved in regulating erectile tissue function.

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Effect of allopurinol on lipid peroxidation induced in corporeal tissue by veno‐occlusive priapism in a rat model

Cited by 20 publications

References 6 publications

Experimental priapism is associated with increased oxidative stress and activation of protein degradation pathways in corporal tissue

Experimental priapism is associated with increased oxidative stress and activation of protein degradation pathways in corporal tissue

TGF-β1 neutralizing antibodies decrease the fibrotic effects of ischemic priapism

Priapism pathophysiology: clues to prevention

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