Effect of Allo- and Xenotransplantation of Embryonic Nervous Tissue and Umbilical Cord Blood-Derived Stem Cells on Structural and Functional State of Cerebral Cortex of Albino Rats in Posttraumatic Period

Ereniev, S. I.; Semchenko, V. V.; Sysheva, E. V.; Bogdashin, I. V.; Shapovalova, V. V.; Khizhnyak, A. S.; Gasanenko, L. N.

doi:10.1007/s10517-006-0037-z

Cited by 2 publications

(1 citation statement)

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“…In all these reports HUCB cell administrated intravenously or intraperitonealy modified positively the severity of neurological deficits caused by middle cerebral artery occlusion (MCAO) Vendrame et al, 2004;Xiao et al, 2005;Newcomb et al, 2006;Meier et al, 2006). Also intravenous administration of umbilical cord blood improved functional state of the brain and behavioral deficits in rats suffering from hemorrhagic or traumatic brain and spinal cord injury Lu et al, 2002;Ereniev et al, 2005;Saporta et al, 2003). All these data suggest that cells with neural progenitor properties are contributing substantially to all these CB therapeutic effects.…”

Section: The Cord Blood Challenge For Brain Repairmentioning

confidence: 95%

A novel, neural potential of non-hematopoietic human umbilical cord blood stem cells

Domanska-Janik¹,

Bużañska²,

Łukomska³

2008

Int. J. Dev. Biol.

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From the time of discovery that among the cord blood mononuclear cell population there are cells capable of changing their fate towards the neural lineage and producing functional neurons and macroglial cells, our attempts have been focused on the understanding of the underlying mechanism of this transition. We have deciphered the first steps of neural stem/ progenitor gene induction in aggregating culture of cord blood mononuclear cells, their rapid phenotypic conversion under the influence of neuromorphogenic signals due to mitogen activation and their ability to expand and develop a prototypic, long-living line with neural stem cell properties. Evidence has accumulated that human umbilical cord-derived and neurally committed cells, due to their capacity for self-renewal, multilineage differentiation, plasticity and ability for long-lasting growth in vitro, provide unique material for the cell therapy of a wide spectrum of neurological diseases. The putative regenerating potential of these cord blood-derived neural stem/progenitor cells was evaluated after transplantation in experimental models of brain injury. In spite of initial promising data, the results indicate an urgent need to improve available animal model protocols in order to increase immuno-tolerance toward transplanted human cells.

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