Effect of alimentary synthetic estrogen on cell compensatory mechanisms in rats of different ages

Abstract

Results of a study of lipid peroxidation, antioxidant system components, and cholinergic neurotransmitter system in the organs of experimental rats of different ages exposed to alimentary synthetic estrogen are presented. Given the state of peroxidation processes and AChE activities in female rats exposed to xenoestrogen, it is possible to assume the possibility of the restructuring of the functioning of mediator and enzyme systems and additional strengthening of pathological symptoms. In the future, such phenomena may trigger the reduction of potential of compensatory mechanisms in compromising the health of the consumers. In puberty, females were more sensitive to nutritional synthetic estrogen than mature animals, thus proving that age is another factor in xenoestrogen exposure. Because of the changes in the rates of reactions to detoxification but not to the metabolism of estrogen received into the organism, particularly with food, with age the animals were less susceptible to the effects of these substances.

Cytoprotective processes induced by the effect of L-arginin-L-glutamate in rats with experimental pathology of the gastroduodenal zone

“…За відсутності патологічного процесу в СО гастродуоденальної зони відмічається збалансована активність ферментативних систем, що генерують АФК, і систем антиоксидантного захисту (АОЗ). Порушення балансу між утворенням АФК та їх утилізацією, що викликають надмірне накопичення продуктів перекисного окиснення ліпідів (ПОЛ), характеризується як окисний стрес (Lykholat et al, 2016b;Yermishev et al, 2017). Дія факторів агресії у СО супроводжується пошкодженням її клітинних структур (насамперед, мітохондрій), що викликає порушення мітохондріального трансмембранного потенціалу та виток мітохондріального супероксиду.…”

Industrial characteristics and consumer properties of Chaenomeles Lindl. fruits

“…The environmental effects of different nature xenobiotics and arid climate in the Steppe Dnieper negatively influence on all elements of ecosystems: soil, in particular, devastated (Savosko, 2011;Savosko et al, 2018), plant metabolism (Myitsyik & Lykholat, 2000;Grygoryuk et al, 2014;Lykholat et al, 2017Lykholat et al, , 2018Opanasenko et al, 1998) and animal organisms (Andrusevich et al, 2018;Lykholat et al, 2016Lykholat et al, , 2018Lykholat et al, , 2019Pokhylenko et al, 2019), which as result has a adversely impact on health population (Pertseva et al, 2007(Pertseva et al, , 2008Yermishev et al, 2017).…”

Introduction success of less common species from the genus Berberis L.

“…The impact of negative environmental factors on the background of arid steppe climate significantly affects all elements of ecosystems, causing soil impoverishment (Savosko, 2011;Savosko et al, 2018), changes in the composition of plant communities (Baranovski et al, 2017;Chytry et al, 2017;Shupranova et al, 2017;Klymenko et al, 2017;Lykholat et al, 2018bNazarenko & Lykholat, 2018a;Nazarenko et al, 2018b), changes in the spread of animal organisms and their metabolism (Brygadyrenko, 2015;Andrusevich et al, 2018;Didur et al, 2018;Lykholat et al, 2016aLykholat et al, , 2018aMarenkov et al, 2019;Pokhylenko et al, 2019), as well as negative effects on the human health (Lykholat et al, 2016b;Pertseva et al, 2012;Yermishev et al, 2017). In the steppe zone of Ukraine, maintaining the existing plant diversity and expanding its spectrum can be effective if species are introduced from other geographical areas.…”