Effect of Alcohol on Anterior-Pituitary Secretion of Trophic Hormones

Ylikahri, Reino; Huttunen, M; Härkönen, Matti

doi:10.1016/s0140-6736(76)92690-8

Cited by 27 publications

(6 citation statements)

References 1 publication

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“…In fact, many older studies included men only. For example, until 2004, studies on the pathology and physiological correlates of alcohol hangover were solely conducted in male subjects [14,15,16,17,18,19,20,21,22,23,24,25,26,27,28].…”

Section: Introductionmentioning

confidence: 99%

Sex Differences in the Presence and Severity of Alcohol Hangover Symptoms

Pabst

Devenney

Verster

2019

JCM

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Studies have demonstrated significant sex differences in alcohol intoxication effects. In contrast, the majority of studies on the alcohol hangover phase did not investigate sex differences. Therefore, the current study examined possible sex differences in the presence and severity of alcohol hangover symptoms. Data from n = 2446 Dutch students (male = 50.7%, female = 49.3%) were analyzed. They reported the presence and severity of 22 hangover symptoms experienced after their past month heaviest drinking occasion. Subjects were categorized according to their estimated peak blood alcohol concentration (eBAC) and presence and severity of the hangover symptoms were compared between men and women. In the lowest eBAC group (0% ≤ eBAC < 0.08%), no significant sex differences were found. In the subsequent eBAC group (0.08% ≤ eBAC < 0.11%), severity of nausea was significantly higher in women than in men. In the third eBAC group (0.11% ≤ eBAC < 0.2%), women reported higher severity scores on nausea, tiredness, weakness, and dizziness than men. Men reported the presence of confusion significantly more often than women, and women reported the presence of shivering significantly more often than men. In the fourth eBAC group (0.2% ≤ eBAC < 0.3%), women reported higher severity scores on nausea and tiredness than men. In the highest eBAC group (0.3% ≤ eBAC < 0.4%), no significant sex differences were found. In conclusion, across the eBAC groups, severity scores of nausea and tiredness were higher in women than in men. However, albeit statistically significant, the observed sex differences in presence and severity of hangover symptoms were of small magnitude, and therefore, have little clinical relevance.

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Section: Introductionmentioning

confidence: 99%

Sex Differences in the Presence and Severity of Alcohol Hangover Symptoms

Pabst

Devenney

Verster

2019

JCM

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“…Alcohol given acutely to non-alcoholics usually [16], but not invariably [17], increases plasma cortisol. Although we found only small changes in cortisol levels specifically associated with alcohol ingestion, these may add to the pressor action of alcohol by amplifying the cardiac and vascular effects of catecholamines [18].…”

Section: Discussionmentioning

confidence: 97%

Acute effects of moderate alcohol consumption on blood pressure and plasma catecholamines

et al. 1984

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This study examines the response of blood pressure, plasma catecholamines and cortisol to acute alcohol intake in young men with light to moderate drinking habits. Ingestion of alcohol was associated with a highly significant increase in systolic blood pressure and heart rate which occurred before blood alcohol reached its peak concentration of 16.9 +/- 1.1 mmol/l (80 mg/100 ml). After an initial non-specific rise, diastolic pressure fell below values observed after drinking water only. This predominant effect of alcohol on systolic blood pressure is also seen with chronic alcohol consumption. Drinking water and non-alcoholic cold liquids caused a marked fall in plasma adrenaline and a transient rise in noradrenaline concentration. In contrast, drinking alcohol resulted in a relative rise in adrenaline and a delayed increase in noradrenaline concentration. Blood glucose increased after alcohol, supporting a physiological effect of adrenaline on liver glycogenolysis. Plasma cortisol concentration was also significantly higher after drinking alcohol. It is proposed that the relative rise in adrenaline together with higher cortisol levels, repeated over a variable period in susceptible individuals, are implicated in the elevation of blood pressure associated with long term alcohol consumption. It concurs with observations in man and experimental animals of a slow pressor mechanism mediated by adrenaline.

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“…Alcohol given to non-alcoholics usually (Ylikahri et al, 1978) but not always (Prinz et at., 1980) increases plasma cortisol. Although we found only small changes in cortisol levels specifically associated with alcohol ingestion, these may add to the pressor action of alcohol by amplifying the cardiac and vascular effects of catecholamines (Sambhi,Weil & Udhoji,1%2).…”

Section: Discussionmentioning

confidence: 99%

Pressor Effect of Moderate Alcohol Consumption in Man: A Proposed Mechanism

Ireland¹,

Vandongen²,

Davidson³

et al. 1983

Clin Exp Pharma Physio

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Ingestion of alcohol was associated with a highly significant increase in systolic blood pressure and heart rate which occurred before the blood alcohol reached its peak concentration of 16.9 (s.e.m. = 1.1) mol/1. Drinking non-alcoholic cold liquids caused a marked but transient fall in adrenaline and a rise in noradrenaline concentration. Alcohol prevented this fall in adrenaline and led to a sustained increase in noradrenaline concentration. These changes may be implicated in the elevation of blood pressure associated with alcohol consumption.

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Effect of Alcohol on Anterior-Pituitary Secretion of Trophic Hormones

Cited by 27 publications

References 1 publication

Sex Differences in the Presence and Severity of Alcohol Hangover Symptoms

Sex Differences in the Presence and Severity of Alcohol Hangover Symptoms

Acute effects of moderate alcohol consumption on blood pressure and plasma catecholamines

Pressor Effect of Moderate Alcohol Consumption in Man: A Proposed Mechanism

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