Effect of Alcohol Ingestion on Regional Cerebral Blood Flow

Newlin, David B.; Golden, Charles J.; Quaife, Merton A.; Graber, Benjamin

doi:10.3109/00207458208985916

Cited by 52 publications

(25 citation statements)

References 24 publications

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“…Investigators have found decreased rCBF in cerebellum and increased rCBF in the parietal and prefrontal cortex (Volkow et al, 1990), increased rCBF in the frontal cortex only (Matthew and Wilson, 1986), increased rCBF in the right prefrontal cortex (Tiihonen et al, 1994), and increased rCBF in all gray matter areas except the left anterior cortical areas (Newlin et al, 1982). Decreased CMRglu was found in frontal cortices (De Wit et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

Alcohol Reduces Prefrontal Cortical Excitability in Humans: A Combined TMS and EEG Study

Kähkönen

Wilenius

Nikulin

et al. 2002

Neuropsychopharmacol

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The effects of alcohol (0.8 g/kg) on the prefrontal cortex were studied in nine healthy subjects using the technique of transcranial magnetic stimulation (TMS) combined with electroencephalography (EEG). A total of 120 magnetic pulses were delivered with a figureof-eight coil to the left prefrontal cortex at the rate of 0.4-0.7 Hz. The EEG was recorded simultaneously with 60 scalp electrodes (41 electrodes were used for analysis); the TMS-evoked activation was estimated by the area under the global mean field amplitude (GMFA) time curve. TMS caused changes in EEG activity lasting up to 270 ms poststimulus. Alcohol decreased GMFA at 30-270 ms poststimulus (713 7 303 vs 478 7 142 mV ms; p ¼ 0.007). Alcohol-induced differences were most pronounced at anterior electrodes. These results suggest that alcohol reduces the excitability in the prefrontal cortex.

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Section: Introductionmentioning

confidence: 99%

Alcohol Reduces Prefrontal Cortical Excitability in Humans: A Combined TMS and EEG Study

Kähkönen

Wilenius

Nikulin

et al. 2002

Neuropsychopharmacol

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“…Several investigations of normal, healthy subjects have revealed that moderate ethanol inebriation is followed by a global increase in cerebral blood flow (CBF) during rest (Mathew & Wilson, 1986;Newlin, Golden, Quaife, & Graber, 1982;Sano et al, 1993). Most likely this is caused by a global vasodilatatory effect of ethanol (Greenberg et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Ethanol Reduces rCFB Activation of Left Dorsolateral Prefrontal Cortex during a Verbal Fluency Task

Wendt

Risberg

2001

Brain and Language

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“…The changes were most obvious in the frontal areas. Newlin and associates 20 also reported more marked post-ethanol CBF increase in the frontal regions. However, unlike their findings, in the present study there were no significant interhemispheric differences in the flow change.…”

Section: Discussionmentioning

confidence: 85%

“…However, during severe alcohol intoxication with high blood levels (.32 mg/percent) there was a pronounced increase in cerebral blood flow and reduction in cerebral vascular resistance and oxygen uptake. More recently, Newlin and associates 20 studied the effects of ethanol on CBF with the '"Xenon inhalation technique in 10 social drinkers. CBF was measured one hour after the oral administration of .75 g per kg body weight of alcohol.…”

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confidence: 99%

Regional cerebral blood flow changes associated with ethanol intoxication.

Mathew¹,

Wilson²

1986

Stroke

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SEVERAL INVESTIGATORS have reported an association between alcohol abuse and cerebrovascular disease.1 "* Neuropsychiatric complications of chronic, excessive consumption of ethyl alcohol are often associated with significant reductions in cerebral blood flow (CBF).9 -" Reduction in cerebral blood flow is seen following acute ethanol withdrawal with normalization in a few days. 12Studies on the acute effect of ethanol on CBF have produced conflicting results. Most animal studies indicate a vasoconstrictive effect. -16 Sutherland and associates' 7 measured CBF and cerebral metabolism via the nitrous oxide technique, before and twenty minutes after the oral administration of 1 g of alcohol per kg body weight in eleven males with a history of problem drinking. Alcohol ingestion was not associated with any changes in CBF or the metabolic rates of oxygen consumption or carbon dioxide production. Hine and associates 18 studied ten males who had been drinking periodically or chronically for 10-25 years. CBF was measured with the nitrous oxide technique before and twenty minutes after the oral administration of .5 ml of 90 proof whiskey per kg body weight. Post ethanol CBF values showed statistically significant decrease. However, the authors stated that the CBF decrease was very modest and inconsistent in spite of the statistical significance. There were no changes in cerebral metabolic rates for oxygen. Battey and associates 19 examined the effect of intravenous infusions of 5-10 percent solutions of ethyl alcohol (average quantity -22 cc) in 15 patients convalescing from a variety of medical illnesses. CBF measurements were performed with the nitrous oxide inhalation technique before and during the infusions. CBF was also measured in a second group of subjects who were brought to the hospital emergency room with severe alcoholic intoxication, 1-2 hours after admission and 15-62 hours later, when they were sober. Low concentrations of blood alcohol (.068 mg/percent) did not produce significant changes in either cerebral blood flow or oxygen consumption. However, during severe alcohol intoxication with high

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Effect of Alcohol Ingestion on Regional Cerebral Blood Flow

Cited by 52 publications

References 24 publications

Alcohol Reduces Prefrontal Cortical Excitability in Humans: A Combined TMS and EEG Study

Alcohol Reduces Prefrontal Cortical Excitability in Humans: A Combined TMS and EEG Study

Ethanol Reduces rCFB Activation of Left Dorsolateral Prefrontal Cortex during a Verbal Fluency Task

Regional cerebral blood flow changes associated with ethanol intoxication.

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