Effect of alcohol in traumatic brain injury: is it really protective?

Pandit, Viraj; Patel, Nikita; Rhee, Peter; Kulvatunyou, Narong; Aziz, Hassan; Green, Donald J.; OʼKeeffe, Terence; Zangbar, Bardiya; Tang, Andrew; Gries, Lynn; Friese, Randall S.; Joseph, Bellal

doi:10.1016/j.jss.2014.04.039

Cited by 43 publications

(43 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Importantly, conflictive data have highlighted that alcohol use was not associated with the increased incidence of infectious post-injury complications or mortality, or even alcohol increased the risk for development of in-hospital complications [42, 43]. The authors correlate their findings to possible anti-inflammatory characteristic of alcohol, since in numerous studies, alcohol was reported to significantly impact the immune response by suppressing the pro-inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, positive BAC has been associated with lower leukocyte counts as well as systemic IL-6 levels in severe TBI or in major trauma patients [8, 16]. However, contradictory data showing deteriorating effects of an alcohol intoxication also on patients´ outcome have been reported as well [43, 56, 57]. Nonetheless, the therapeutic use of alcohol is surely to be assessed critically because of its well-described side effects, notably regarding the central nervous system, e.g.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ethanol Decreases Inflammatory Response in Human Lung Epithelial Cells by Inhibiting the Canonical NF-kB-Pathway

Mörs¹,

Hörauf²,

Kany³

et al. 2017

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Alcohol (ethanol, EtOH) as significant contributor to traumatic injury is linked to suppressed inflammatory response, thereby influencing clinical outcomes. Alcohol-induced immune-suppression during acute inflammation (trauma) was linked to nuclear factor-kappaB (NF-ĸB). Here, we analyzed alcohol`s effects and mechanisms underlying its influence on NF-ĸB-signaling during acute inflammation in human lung epithelial cells. Methods: A549-cells were stimulated with interleukin (IL)-1β, or sera from trauma patients (TP) or healthy volunteers, with positive/negative blood alcohol concentrations (BAC), and subsequently exposed to EtOH (170 Mm, 1h). IL-6-release and neutrophil adhesion to A549 were analyzed. Specific siRNA-NIK mediated downregulation of non-canonical, and IKK-NBD-inhibition of canonical NF-ĸB signaling were performed. Nuclear levels of activated p50 and p52 NF-ĸB-subunits were detected using TransAm ELISA. Results: Both stimuli significantly induced IL-6-release (39.79±4.70 vs. 0.58±0.8 pg/ml) and neutrophil adhesion (132.30±8.80 vs. 100% control, p<0.05) to A549-cells. EtOH significantly decreased IL-6-release (22.90±5.40, p<0.05) and neutrophil adherence vs. controls (105.40±14.5%, p<0.05). IL-1β-induced significant activation of canonical/p50 and non-canonical/p52 pathways. EtOH significantly reduced p50 (34.90±23.70 vs. 197.70±36.43, p<0.05) not p52 activation. Inhibition of canonical pathway was further increased by EtOH (less p50-activation), while p52 remained unaltered. Inhibition of non-canonical pathway was unchanged by EtOH. Conclusion: Here, alcohol`s anti-inflammatory effects are mediated via decreasing nuclear levels of activated p50-subunit and canonical NF-ĸB signaling pathway.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ethanol Decreases Inflammatory Response in Human Lung Epithelial Cells by Inhibiting the Canonical NF-kB-Pathway

Mörs¹,

Hörauf²,

Kany³

et al. 2017

Cell Physiol Biochem

View full text Add to dashboard Cite

show abstract

“…On the other hand, Tien et al and Pandit et al, in their respective cohort studies, demonstrated that ethanol was associated with a higher mortality as blood ethanol levels increased [32,33]. In an analysis of the American National Trauma Data Bank, Pandit et al reported that ethanol exposure was also associated with higher complication rates, including infections (pneumonia, urinary tract infections, sepsis), haematological complications (deep venous thrombosis, pulmonary embolism) and acute respiratory distress syndrome [33].…”

Section: Discussionmentioning

confidence: 99%

“…Ethanol has been shown to be both protective [5,[28][29][30][31], harmful [32,33] and to have no effect on outcomes following iTBI [6,[34][35][36]. A recent systematic review addressing this topic concluded that ethanol exposure was associated with improved outcomes after iTBI [37].…”

Section: Discussionmentioning

confidence: 99%

Ethanol exposure and isolated traumatic brain injury

Brennan

Bernard

Cameron

et al. 2015

Journal of Clinical Neuroscience

View full text Add to dashboard Cite

“…20 , pointed that intoxication with ethanol in patients victims of severe TBI is not directly related to mortality. However, there is a higher frequency of hospital complications in the group of patients that made use of alcohol 19 . One possible explanation would be the fact of prior exposure to ethanol intensifies neuroinflammatory response after TBI 20 .…”

Section: Discussionmentioning

confidence: 99%

Hemotransfusion and mechanical ventilation time are associated with intra-hospital mortality in patients with traumatic brain injury admitted to intensive care unit

Almeida¹,

Rodrigues

Lemos

et al. 2016

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

Objective To identify the factors associated with the intra-hospital mortality in patients with traumatic brain injury (TBI) admitted to intensive care unit (ICU). Methods The sample included patients with TBI admitted to the ICU consecutively in a period of one year. It was defined as variables the epidemiological characteristics, factors associated with trauma and variables arising from clinical management in the ICU. Results The sample included 87 TBI patients with a mean age of 28.93 ± 12.72 years, predominantly male (88.5%). The intra-hospital mortality rate was of 33.33%. The initial univariate analysis showed a significant correlation of intra-hospital death and the following variables: the reported use of alcohol (p = 0.016), hemotransfusion during hospitalization (p = 0.036), and mechanical ventilation time (p = 0.002). Conclusion After multivariate analysis, the factors associated with intra-hospital mortality in TBI patients admitted to the intensive care unit were the administration of hemocomponents and mechanical ventilation time.

show abstract

Effect of alcohol in traumatic brain injury: is it really protective?

Cited by 43 publications

References 21 publications

Ethanol Decreases Inflammatory Response in Human Lung Epithelial Cells by Inhibiting the Canonical NF-kB-Pathway

Ethanol Decreases Inflammatory Response in Human Lung Epithelial Cells by Inhibiting the Canonical NF-kB-Pathway

Ethanol exposure and isolated traumatic brain injury

Hemotransfusion and mechanical ventilation time are associated with intra-hospital mortality in patients with traumatic brain injury admitted to intensive care unit

Contact Info

Product

Resources

About