Effect of Alcohol Consumption on Diabetes Mellitus

Howard, Andrea A.; Arnsten, Julia H.; Gourevitch, Marc N.

doi:10.7326/0003-4819-140-6-200403160-00011

Cited by 457 publications

(339 citation statements)

References 44 publications

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“…Light to moderate intake is associated with improved insulin sensitivity (Facchini et al, 1994;Kiechl et al, 1996;Lazarus et al, 1997;Davies et al, 2002) and with a lower risk of diabetes (Howard et al, 2004). Because obesity is a risk factor for renal cell cancer (Calle and Kaaks, 2004), and diabetics are at higher risk than those without diabetes (Wideroff et al, 1997;Lindblad et al, 1999), it is possible that improved insulin sensitivity lowers renal cell cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Alcoholic beverages and risk of renal cell cancer

et al. 2007

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Using a mailed questionnaire, we investigated the risk of renal cell cancer in relation to different types of alcoholic beverages, and to total ethanol in a large population-based case -control study among Swedish adults, including 855 cases and 1204 controls. Compared to non-drinkers, a total ethanol intake of 4620 g month À1 was significantly related to a decreased risk of renal cell cancer (odds ratio (OR) 0.6, 95% confidence interval (CI) 0.4 -0.9; P-value for trend ¼ 0.03). The risk decreased 30 -40% with drinking more than two glasses per week of red wine (OR 0.6, 95% CI 0.4 -0.9), white wine (OR 0.7, 95% CI 0.4 -1.0), or strong beer (OR 0.6, 95% CI 0.4 -1.0); there was a clear linear trend of decreasing risk with increasing consumption of these beverages (P-values for trends o0.05).

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Section: Discussionmentioning

confidence: 99%

Alcoholic beverages and risk of renal cell cancer

et al. 2007

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“…Multiple factors have been associated with NAFLD including obesity, central adiposity, type 2 diabetes, and hyperlipidemia with insulin resistance postulated as an essential factor. Interestingly, the role of insulin resistance in alcoholdependent liver has been invoked; however, the data in support of this mechanism is equivocal [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases

Mantena

King

Andringa

et al. 2008

Free Radical Biology and Medicine

382

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Fatty liver disease associated with chronic alcohol consumption or obesity/type 2 diabetes has emerged as a serious public health problem. Steatosis, accumulation of triglyceride in hepatocytes, is now recognized as a critical "first-hit" in the pathogenesis of liver disease. It is proposed that steatosis "primes" the liver to progress to more severe liver pathologies when individuals are exposed to subsequent metabolic and/or environmental stressors or "second-hits". Genetic risk factors can also influence the susceptibility and severity of fatty liver disease. Furthermore, oxidative stress, disrupted nitric oxide (NO) signaling, and mitochondrial dysfunctional are proposed to be key molecular events that accelerate or worsen steatosis and initiate progression to steatohepatitis and fibrosis. This review article will discuss the following topics regarding the pathobiology and molecular mechanisms responsible for fatty liver disease: 1) the "two-hit" or "multi-hit" hypothesis; 2) the role of mitochondrial bioenergetic defects and oxidant stress; 3) interplay between NO and mitochondria in fatty liver disease; 4) genetic risk factors and oxidative stress responsive genes; and 5) the feasibility of antioxidants for treatment.

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“…12 In a study using 2005 and 2006 data from the National Survey on Drug Use and Health, 13 % of men and 8 % of women aged 65 and older reported drinking two or more drinks per day. 13 Although low to moderate levels of alcohol use can have health benefits, [14][15][16][17][18] the exact benefit dose is not known and may not be risk free. [19][20][21][22] While alcohol consumption within guidelines may be permissible in some individuals with diabetes and cardiovascular disease, alcohol is not advised with certain prescription medications and can cause serious consequences.…”

Section: Introductionmentioning

confidence: 99%

“…Reviews of studies on persons with diabetes, cardiovascular disease, coronary artery disease or stroke found associations between light to moderate alcohol consumption and reduced risks of cardiovascular events, mortality and recurrent stroke. 16,18 Thus, alcohol use among older adults with chronic conditions is a complex issue and needs additional research and clinical attention. One initial step is to estimate the prevalence of drinking patterns in older adults with chronic conditions.…”

Section: Introductionmentioning

confidence: 99%

Drinking Patterns of Older Adults with Chronic Medical Conditions

et al. 2013

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BACKGROUND: Understanding alcohol consumption patterns of older adults with chronic illness is important given the aging baby boomer generation, the increase in prevalence of chronic conditions and associated medication use, and the potential consequences of excessive drinking in this population. OBJECTIVES: To estimate the prevalence of alcohol consumption patterns, including at-risk drinking, in older adults with at least one of seven common chronic conditions. DESIGN/METHODS: This descriptive study used the nationally representative 2005 Medicare Current Beneficiary Survey linked with Medicare claims. The sample included community-dwelling, fee-for-service beneficiaries 65 years and older with one or more of seven chronic conditions (Alzheimer's disease and other senile dementia, chronic obstructive pulmonary disease, depression, diabetes, heart failure, hypertension, and stroke; n=7,422). Based on selfreported alcohol consumption, individuals were categorized as nondrinkers, within-guidelines drinkers, or at-risk drinkers (exceeds guidelines). RESULTS: Overall, 30.9 % (CI 28.0-34.1 %) of older adults with at least one of seven chronic conditions reported alcohol consumption in a typical month in the past year, and 6.9 % (CI 6.0-7.8 %) reported at-risk drinking. Older adults with higher chronic disease burdens were less likely to report alcohol consumption and at-risk drinking. CONCLUSIONS: Nearly one-third of older adults with selected chronic illnesses report drinking alcohol and almost 7 % drink in excess of National Institute on Alcohol Abuse and Alcoholism (NIAAA) guidelines. It is important for physicians and patients to discuss alcohol consumption as a component of chronic illness management. In cases of at-risk drinking, providers have an opportunity to provide brief intervention or to offer referrals if needed.

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Effect of Alcohol Consumption on Diabetes Mellitus

Cited by 457 publications

References 44 publications

Alcoholic beverages and risk of renal cell cancer

Alcoholic beverages and risk of renal cell cancer

Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases

Drinking Patterns of Older Adults with Chronic Medical Conditions

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