Effect of alcohol consumption on risk of hypertension based on alcohol-related facial flushing response: From the health examinees study

Cho, Seung Yeon; Jeong, Jiwon; Shin, Sangah

doi:10.1016/j.alcohol.2024.02.010

Alcohol

2024

DOI: 10.1016/j.alcohol.2024.02.010

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Effect of alcohol consumption on risk of hypertension based on alcohol-related facial flushing response: From the health examinees study

Seung Yeon Cho,

Jiwon Jeong,

Sangah Shin

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Acceleration of Ethanol Metabolism by a Patented Bos taurus Isolated Alcohol Degradation Protein (ADP) on Acute Alcohol Consumption

Tsoi,

Zhang,

et al. 2024

Foods

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Alcoholic beverages are among the most widely enjoyed leisure drinks around the world. However, irresponsible drinking habits can have detrimental effects on human health. Therefore, exploring strategies to alleviate discomfort following alcohol consumption would be beneficial for individuals who inevitably need to consume alcohol. In this study, three different models were used to determine the efficacy of a patented alcohol degradation protein (ADP) extracted from Bos taurus on ethanol metabolism. In an ethanol-challenged HepG2 cell model, ADP significantly protected the cell from ethanol-induced toxicity. Subsequently, results demonstrated that ADP significantly alleviated the effect of ethanol, as reflected by the increased distance and activity time of zebrafish during the testing period. Additionally, in a rat model, ADP promoted ethanol degradation at 1 and 2 h after ethanol consumption. Mechanistic studies found that ADP treatment increased ADH and ALDH activity in the gastrointestinal tract. ADP also exhibited potent antioxidation effects by lowering HO-1 expression in the liver. In conclusion, we believe that ADP is a promising product for relieving hangover symptoms after ethanol consumption, with demonstrated safety and effectiveness at the recommended dosage.

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Acceleration of Ethanol Metabolism by a Patented Bos taurus Isolated Alcohol Degradation Protein (ADP) on Acute Alcohol Consumption

Tsoi,

Zhang,

et al. 2024

Foods

View full text Add to dashboard Cite

show abstract

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Effect of alcohol consumption on risk of hypertension based on alcohol-related facial flushing response: From the health examinees study

Cited by 1 publication

References 31 publications

Acceleration of Ethanol Metabolism by a Patented Bos taurus Isolated Alcohol Degradation Protein (ADP) on Acute Alcohol Consumption

Acceleration of Ethanol Metabolism by a Patented Bos taurus Isolated Alcohol Degradation Protein (ADP) on Acute Alcohol Consumption

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