Effect of alcohol, cigarette smoking, and diabetes on occurrence of hepatocellular carcinoma in patients with transfusion-acquired hepatitis C virus infection who develop cirrhosis

Costanzo, Giovan Giuseppe Di; Luca, Massimo De; Tritto, Giovanni; Lampasi, F.; Addario, Luigi; Lanza, A; Tartaglione, M.T.; Picciotto, Francesco; Ascione, Antonio

doi:10.1097/meg.0b013e3282f762e1

Cited by 19 publications

(14 citation statements)

References 27 publications

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“…Of the 102 possibly eligible studies after the initial screening, the full text search that ensued resulted in removal of 21 studies. Hence, 81 studies were included in the systematic review . Seventy‐two studies assessed the association between smoking and risk of development of HCC and nine studies assessed the association between smoking and the risk of mortality in HCC patients.…”

Section: Resultsmentioning

confidence: 99%

Cigarette smoking as a risk factor for the development of and mortality from hepatocellular carcinoma: An updated systematic review of 81 epidemiological studies

et al. 2017

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Section: Resultsmentioning

confidence: 99%

Cigarette smoking as a risk factor for the development of and mortality from hepatocellular carcinoma: An updated systematic review of 81 epidemiological studies

et al. 2017

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“…We identified 32 cohort studies reporting the association of diabetes and HCC . There were 25 studies reporting risk of HCC incidence (Table ), and 7 studies reporting risk of mortality from HCC (Table ).…”

Section: Resultsmentioning

confidence: 99%

Diabetes mellitus and risk of hepatocellular carcinoma: a systematic review and meta‐analysis

Wang

Kang

Cao

et al. 2012

Diabetes Metabolism Res

269

191

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Studies of diabetes and hepatocellular carcinoma (HCC) yielded inconsistent findings. This meta-analysis was conducted to examine the association between diabetes and risk of HCC. Studies were identified by searching PUBMED and MEDLINE database up to February 2011. Pooled risk estimates were calculated using the random-effects model. Potential sources of heterogeneity were explored by subgroup analyses. A total of 17 case-control studies and 32 cohort studies were included in the meta-analysis. The combined risk estimate of all studies showed a statistically significant increased risk of HCC prevalence among diabetic individuals (RR = 2.31, 95% CI: 1.87-2.84). The pooled risk estimate of 17 case-control studies (OR = 2.40, 95% CI: 1.85-3.11) was slightly higher than that from 25 cohort studies (RR = 2.23, 95% CI: 1.68-2.96). Metformin treatment was potentially protective. On the contrary, long duration of diabetes and sulfonylureas or insulin treatment possibly increase HCC risk. Also meta-analysis of 7 cohort studies found a statistically significant increased risk of HCC mortality (RR = 2.43, 95% CI: 1.66-3.55) for individuals with (versus without) diabetes. This meta-analysis shows that diabetes is associated with moderately increased risk of HCC prevalence, as well as HCC mortality. Considering the rapidly increasing prevalence of diabetes mellitus, the study underlines the need for cancer prevention in diabetic individuals. Further investigation is needed to focus on the potential mechanism for the pathogenesis of HCC and the link between HCC and different types, severity, treatment and duration of diabetes.

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“…All included studies were published between 1998 and 2010, of which 64% (n = 18) were published in 2005 or more recent years. The studies were conducted in the following regions: Japan (n = 9) [20], [22], [23], [25], [57]–[59], [68], [69], China (n = 8) [18], [21], [26], [55], [62], [65]–[67],Korea (n = 2) [60], [61], USA (n = 3) [24], [29], [63], Europe (n = 4) [19], [27], [28], [64], Israel (n = 1) [17] and other regions (n = 1) [56]. The cohort ranged in size from 40 [57] to 1,298,385 [61].The duration of follow-up ranged from 2.78 years [21] to 25 years [64] in population-based cohort studies and ranged from 18 months [55] to 7 years [8] in clinic-based cohort studies.…”

Section: Resultsmentioning

confidence: 99%

The Role of Pre-Existing Diabetes Mellitus on Hepatocellular Carcinoma Occurrence and Prognosis: A Meta-Analysis of Prospective Cohort Studies

et al. 2011

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BackgroundThe impact of pre-existing diabetes mellitus (DM) on hepatocellular carcinoma (HCC) occurrence and prognosis is complex and unclear. The aim of this meta-analysis is to evaluate the association between pre-existing diabetes mellitus and hepatocellular carcinoma occurrence and prognosis.MethodsWe searched PubMed, Embase and the Cochrane Library from their inception to January, 2011 for prospective epidemiological studies assessing the effect of pre-existing diabetes mellitus on hepatocellular carcinoma occurrence, mortality outcomes, cancer recurrence, and treatment-related complications. Study-specific risk estimates were combined by using fixed effect or random effect models.ResultsThe database search generated a total of 28 prospective studies that met the inclusion criteria. Among these studies, 14 reported the risk of HCC incidence and 6 studies reported risk of HCC specific mortality. Six studies provided a total of 8 results for all-cause mortality in HCC patients. Four studies documented HCC recurrence risks and 2 studies reported risks for hepatic decomposition occurrence in HCC patients. Meta-analysis indicated that pre-existing diabetes mellitus (DM) was significantly associated with increased risk of HCC incidence [meta-relative risk (RR) = 1.87, 95% confidence interval (CI): 1.15–2.27] and HCC-specific mortality (meta-RR = 1.88, 95%CI: 1.39–2.55) compared with their non-DM counterparts. HCC patients with pre-existing DM had a 38% increased (95% CI: 1.13–1.48) risk of death from all-causes and 91% increased (95%CI: 1.41–2.57) risk of hepatic decomposition occurrence compared to those without DM. In DM patients, the meta-RR for HCC recurrence-free survival was 1.93(95%CI: 1.12–3.33) compared with non-diabetic patients.ConclusionThe findings from the current meta-analysis suggest that DM may be both associated with elevated risks of both HCC incidence and mortality. Furthermore, HCC patients with pre-existing diabetes have a poorer prognosis relative to their non-diabetic counterparts.

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Effect of alcohol, cigarette smoking, and diabetes on occurrence of hepatocellular carcinoma in patients with transfusion-acquired hepatitis C virus infection who develop cirrhosis

Abstract: Diabetes, smoking, and alcohol drinking were not independently related to the risk of developing hepatocellular carcinoma in hepatitis C virus-related cirrhosis.

Cited by 19 publications

References 27 publications

Cigarette smoking as a risk factor for the development of and mortality from hepatocellular carcinoma: An updated systematic review of 81 epidemiological studies

Cigarette smoking as a risk factor for the development of and mortality from hepatocellular carcinoma: An updated systematic review of 81 epidemiological studies

Diabetes mellitus and risk of hepatocellular carcinoma: a systematic review and meta‐analysis

The Role of Pre-Existing Diabetes Mellitus on Hepatocellular Carcinoma Occurrence and Prognosis: A Meta-Analysis of Prospective Cohort Studies

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