Abstract:Under physiological conditions, nanoparticles (NPs) inevitably interact with proteins, resulting in extensive protein adsorption and the formation of a protein corona. Recent studies have shown that the different surface properties of NPs lead to varying degrees of conformational changes of adsorbed proteins. However, the impact of corona protein conformation on the in vitro and in vivo profiles of NPs remain largely unexplored. Herein, D-α-tocopherol polyethylene glycol 1000 succinate-based NPs with natural h… Show more
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