Effect of airborne particulate matter of 2.5 μm or less on preterm birth: A national birth cohort study in China

Li, Qin; Wang, Yuan Yuan; Lee, Hyewon; Zhou, Hong; Wang, Xiaobin; Wang, Qiaomei; Shen, Haiping; Zhang, Yiping; Yan, Donghai; Ya, Zhang; Zhang, Honggang; Li, Shanshan; Chen, Gongbo; Lin, Lizi; Zhao, Jun; He, Yuan; Yang, Ying; Xu, Jing; Wang, Yan; Peng, Zuoqi; Wang, Hai Jun; Ma, Xu

doi:10.1016/j.envint.2018.10.025

Cited by 58 publications

(36 citation statements)

References 33 publications

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“…So, women in poor physical conditions prefer to deliver at this hospital. Based on inclusion and exclusion criteria in previous researches [12,22], we excluded multiple pregnancies, stillbirths, birth defects, neonates with an extreme birth weight (< 500 g or > 5000 g), and neonates whose gestational age were less than 20 weeks or more than 42 weeks. Pregnant women whose permanent addresses were not located in Wuhan and whose addresses could not be geocoded were also excluded.…”

Section: Study Populationmentioning

confidence: 99%

“…The first trimester was defined as the conception date to 13 weeks, the second trimester as 14 weeks to 27 weeks, and the third trimester as 28 weeks to birth [16]. Pregnancy outcomes in this study included term birth (gestational age ≥ 37 weeks and ≤ 42 weeks), PTB (20 to < 37 gestational weeks) [1], extremely preterm birth (ExPTB, < 28 weeks), very preterm birth (VPTB, 28 to < 32 weeks), and moderate preterm birth (MPTB, 32 to < 37 weeks) [12].…”

Section: Definition Of Birth Outcomes and Exposure Windowmentioning

confidence: 99%

“…In recent years, numerous studies have reported the effects of long-term or short-term air pollutant exposure on PTB [8,9], especially the impact of maternal fine particulate matter (PM 2.5 , aerodynamic diameter < 2.5 μm) exposure on PTB, which has become an intriguing research topic [10][11][12]. Due to its specific characteristics, including large surface area, small diameter, and extended suspension time in the air [13], PM 2.5 can be inhaled into the deep regions of the lungs.…”

Section: Introductionmentioning

confidence: 99%

“…However, very few studies have investigated the association between air pollution and PTB subtypes [16]. Additionally, although researchers have explored the trimester-specific association between PM 2.5 exposure and PTB [11,12,17], the results regarding the most susceptible exposure window have been inconsistent and remain controversial [18]. The inconsistent results among these studies may be attributed to many factors.…”

Section: Introductionmentioning

confidence: 99%

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Maternal PM2.5 exposure triggers preterm birth: a cross-sectional study in Wuhan, China

Zhang

Fan

Ren

et al. 2020

glob health res policy

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Background: Most of the studies regarding air pollution and preterm birth (PTB) in highly polluted areas have estimated the exposure level based on fixed-site monitoring. However, exposure assessment methods relying on monitors have the potential to cause exposure misclassification due to a lack of spatial variation. In this study, we utilized a land use regression (LUR) model to assess individual exposure, and explored the association between PM 2.5 exposure during each time window and the risk of preterm birth in Wuhan city, China.

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Section: Study Populationmentioning

confidence: 99%

Section: Definition Of Birth Outcomes and Exposure Windowmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Maternal PM2.5 exposure triggers preterm birth: a cross-sectional study in Wuhan, China

Zhang

Fan

Ren

et al. 2020

glob health res policy

View full text Add to dashboard Cite

show abstract

“…A five-fold increase in inflammation, as measured by CRP levels, occurs over the course of normal pregnancy [1], and the fetal impact is unknown. Elevated inflammation beyond the physiological increase during pregnancy has been implicated as a mediator in the associations of a myriad of prenatal exposures (e.g., infectious disease [2], maternal obesity [3,4], maternal stress [5], and air pollution [6]) with offspring health. Moreover, maternal inflammation is linked with preterm birth [7,8], preeclampsia [9,10], and childhood asthma/allergies [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Cord blood DNA methylation reflects cord blood C-reactive protein levels but not maternal levels: a longitudinal study and meta-analysis

et al. 2020

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Background: Prenatal inflammation has been proposed as an important mediating factor in several adverse pregnancy outcomes. C-reactive protein (CRP) is an inflammatory cytokine easily measured in blood. It has clinical value due to its reliability as a biomarker for systemic inflammation and can indicate cellular injury and disease severity. Elevated levels of CRP in adulthood are associated with alterations in DNA methylation. However, no studies have prospectively investigated the relationship between maternal CRP levels and newborn DNA methylation measured by microarray in cord blood with reasonable epigenome-wide coverage. Importantly, the timing of inflammation exposure during pregnancy may also result in different effects. Thus, our objective was to evaluate this prospective association of CRP levels measured during multiple periods of pregnancy and in cord blood at delivery which was available in one cohort (i.e., Effects of Aspirin in Gestation and Reproduction trial), and also to conduct a meta-analysis with available data at one point in pregnancy from three other cohorts from the Pregnancy And Childhood Epigenetics consortium (PACE). Secondarily, the impact of maternal randomization to low dose aspirin prior to pregnancy on methylation was assessed. Results: Maternal CRP levels were not associated with newborn DNA methylation regardless of gestational age of measurement (i.e., CRP at approximately 8, 20, and 36 weeks among 358 newborns in EAGeR). There also was no association in the meta-analyses (all p > 0.5) with a larger sample size (n = 1603) from all participating PACE cohorts with available CRP data from first trimester (< 18 weeks gestation). Randomization to aspirin was not associated with DNA methylation. On the other hand, newborn CRP levels were significantly associated with DNA methylation in the EAGeR trial, with 33 CpGs identified (FDR corrected p < 0.05) when both CRP and methylation were measured at the same time point in cord blood. The top 7 CpGs most strongly associated with CRP resided in inflammation and vascular-related genes.

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Prenatal air pollution exposure and neonatal health

2022

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Air pollution has been shown to have adverse effects on many health outcomes including respiratory effects, cardiovascular effects, and mortality. However, evidence on the effects of prenatal exposure is still limited. We investigate the causal impact of prenatal exposure to air pollution on neonatal health in Italy in the 2000s. We exploit variation in rainfall shocks to instrument for non‐random air pollution exposure. Our empirical setting combines detailed information on mother's residential location from birth certificates with PM10 concentrations from air pollution monitors. Ten additional units in the average PM10 level (approximately one standard deviation) would decrease birth weight by about 0.5% and gestational age by 0.16%; it would increase the prevalence of low birth weight by 22% and of preterm birth by 16%. The effects are stronger in magnitude for third trimester exposure and for less educated mothers. These findings suggest that the health impacts of air pollution on newborns are unequally distributed in the population.

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Effect of airborne particulate matter of 2.5 μm or less on preterm birth: A national birth cohort study in China

Cited by 58 publications

References 33 publications

Maternal PM2.5 exposure triggers preterm birth: a cross-sectional study in Wuhan, China

Maternal PM2.5 exposure triggers preterm birth: a cross-sectional study in Wuhan, China

Cord blood DNA methylation reflects cord blood C-reactive protein levels but not maternal levels: a longitudinal study and meta-analysis

Prenatal air pollution exposure and neonatal health

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Effect of airborne particulate matter of 2.5 μm or less on preterm birth: A national birth cohort study in China

Cited by 58 publications

References 33 publications

Maternal PM2.5 exposure triggers preterm birth: a cross-sectional study in Wuhan, China

Maternal PM2.5 exposure triggers preterm birth: a cross-sectional study in Wuhan, China

Cord blood DNA methylation reflects cord blood C-reactive protein levels but not maternal levels: a longitudinal study and meta-analysis

Prenatal air pollution exposure and neonatal health

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Effect of airborne particulate matter of 2.5 μm or less on preterm birth: A national birth cohort study in China