Effect of aging on tracheal mucociliary clearance in beagle dogs

Whaley, Sandra L.; Muggenburg, B.A.; Seiler, Fritz A.; Wolff, Ronald K.

doi:10.1152/jappl.1987.62.3.1331

Cited by 22 publications

(11 citation statements)

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“…' Group C, dogs with no clinical signs of respiratory disease, situs solitus and normal ultrastructure of nasal cilia that were born from matings between presumed heterozygotes of ICS. Whaley et al [1987]. '' Less than 10% cilia had any motility, and beat was random.…”

Section: Resultsmentioning

confidence: 99%

Familial immotile‐cilia syndrome in English springer spaniel dogs

et al. 1989

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A laboratory-maintained colony of English springer spaniel dogs heterozygous for a putative autosomal recessive immotile-cilia syndrome (ICS) has been studied. Matings between dogs thought to be heterozygous for ICS resulted in 22 pups, five (three males and two females) of which were homozygous for ICS. Four of the five ICS-affected dogs had chronic rhinitis and bronchopneumonia. The other dog had a serious nasal discharge and died at 10 days. Four dogs had situs inversus totalis (kartagener syndrome), and the two males of reproductive age were azoospermic. In the two ICS dogs studied for ciliary function, in vivo mucociliary clearance was absent, and in vitro ciliary beat was rarely observed and of low frequency. Scanning and transmission electron microscopy disclosed the same lesions in respiratory cilia from all dogs with ICS, including random orientation and partial outer dynein arm deficiency. Four of five dogs with ICS had dilated lateral ventricles. One female pup with neonatal rhinitis and bronchopneumonia, situs solitus, and dilated lateral ventricles was presumed to be homozygous for ICS, but died without functional or structural confirmation of defective respiratory cilia. An autosomal recessive mode of inheritance for the ciliary defects and respiratory signs of ICS in these dogs is proposed.

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Section: Resultsmentioning

confidence: 99%

Familial immotile‐cilia syndrome in English springer spaniel dogs

et al. 1989

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“…In healthy dogs, thoracic radiographic findings (Reif and Rhodes, 1966) and tracheobronchial mucociliary clearance (Whaley et al, 1987) are known to be age dependent. One study of 18 Beagle dogs of various ages reported no age-related changes in total and differential cell counts (TCC and DCC) in bronchoalveolar lavage fluid (BALF) (Mayer et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

Influence of age on bronchoscopic findings in healthy beagle dogs

Mercier

Bolognin

Hoffmann

et al. 2011

The Veterinary Journal

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a b s t r a c tThe aims of this study were to evaluate the effect of age on bronchoscopic features and bronchoalveolar lavage fluid (BALF) cellularity in dogs. Thirty healthy beagle dogs from three age groups were included: young dogs (10 months to 4.5 years of age; n = 8), middle-aged dogs (5-8 years old; n = 13) and older dogs (>8 years; n = 9). Haematology, thoracic radiography, bronchoscopy and bronchoalveolar lavage were performed; bronchoscopic findings were scored and BALF total and differential cell counts were determined. The total bronchoscopic score was higher in older dogs; these dogs had more irregular bronchial mucosa, more prominent mucosal vessels and bronchiectasis. Younger dogs had a higher percentage of neutrophils in BALF compared with middle-aged and old dogs and a higher percentage of lymphocytes in BALF compared with middle-aged dogs. The results show that age has an effect on bronchoscopic features of airways and the composition of BALF in the dog.

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“…Significant differences in the tracheal mucus velocity between groups of dogs of different ages were noted. In the course of maturation and ageing, mucus velocity rises exponentially to peak values in young adult dogs and declines linearly thereafter 18 . In mice exposed to inhalation of kaolin conveyed by cigarette smoke, the most severe changes in the pulmonary parenchyma and ultrastructure of alveolar macrophages were recorded in groups of older animals.…”

Section: Discussionmentioning

confidence: 97%

Cytological changes of the respiratory tract in young adults related to high levels of air pollution exposure

Djuričić

Plamenac

1998

Cytopathology

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Several histopathological and cytological studies have shown that lesions of the respiratory tract epithelium become increasingly severe with duration of exposure to high levels of urban air pollution as well as with ageing of studied population groups. In this study we investigated and compared findings of cytological abnormalities in sputa of young adults (21-25 years of age) exposed to high levels of air pollution since birth with those who were exposed in the last 2-3 years only. All subjects were non-smokers and were clinically healthy at the time of sampling. No significant differences in the incidence or severity of any of the cytological findings were found. The fact that even 10 times longer exposure to air pollution resulted in no major respiratory tract epithelial changes is, in our opinion, a result of the extremely efficient defence mechanisms and enormous regenerative potential of the respiratory tract of younger people.

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Effect of aging on tracheal mucociliary clearance in beagle dogs

Cited by 22 publications

References 0 publications

Familial immotile‐cilia syndrome in English springer spaniel dogs

Familial immotile‐cilia syndrome in English springer spaniel dogs

Influence of age on bronchoscopic findings in healthy beagle dogs

Cytological changes of the respiratory tract in young adults related to high levels of air pollution exposure

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