Effect of aging on the release of salbutamol sulfate from lipid matrices

Prilling of fatty acids as a continuous process for the development of controlled release multiparticulate dosage forms

“…Stability issues when using lipid excipients have been reported by different authors [7,10,18]. Influences of storage parameters on drug release were observed by Hamdani et al (2002).…”

“…The prolonged release of phenylephrine hydrochloride from fatty binder mixtures (Precirol ® and Compritol ® ) was significantly affected by storage after 6 weeks at 40 °C and 75 % relative humidity (RH) [7]. In a study performed by San Vicente et al (2000), salbutamol hydrochloride release was altered after storage for 1 year at room temperature, depending on the type of Gelucire used [18].…”

“…Compared to polymers [17], triglycerides exhibit several advantages, including low cost, non-toxicity and biodegradability. Nevertheless, their physical instability during storage (reflected in changes in the melting enthalpy and melting range which modify drug release [10]), remains the main barrier to overcome when applying these excipients for drug formulation [7,18].…”

Prilling as manufacturing technique for multiparticulate lipid/PEG fixed-dose combinations

“…Stability issues when using lipid excipients have been reported by different authors [7,10,18]. Influences of storage parameters on drug release were observed by Hamdani et al 75 % relative humidity (RH) [7].…”

Formulation and Characterization of Floating Gelucire Matrices of Metoprolol Succinate

“…Gelucires are characterized by a wide range of melting points, from about 33 °C to about 65 °C, and by a variety of hydrophilic and lipophilic balance (HLB) values of approximately 1-18 (10,11). Gelucires with low HLB can be employed to decrease the dissolution rate of drugs, and ones with high HLB for fast release (12,13). The advantages of Gelucires over polymers in the design of controlled drug delivery systems include (1) low melt viscosity, obviating the need for solvents; (2) absence of toxic impurities; (3) potential for biocompatibility and biodegradability; and (4) prevention of gastric irritation by forming a coating around the drug (14,15).…”