Effect of aging on tensile mechanical properties of the rabbit distal femoral growth plate

Guse, Roy; Connolly, John F.; Alberts, Russ; Lippiello, Louis

doi:10.1002/jor.1100070506

Cited by 19 publications

(8 citation statements)

References 14 publications

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“…Tensile moduli decrease and ultimate stress and strain increase with development (5 to 12–18 months in bovine growth plate) (Williams et al, 2001). Tensile properties (stiffness and strength) increase during development of rabbits from 20% to 80% of their weight at skeletal maturity (Guse et al, 1989). …”

Section: Growth Plate Behavior Under Mechanical Loadmentioning

confidence: 99%

Growth plate mechanics and mechanobiology. A survey of present understanding

Villemure

Stokes

2009

Journal of Biomechanics

197

160

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The longitudinal growth of long bones occurs in growth plates where chondrocytes synthesize cartilage that is subsequently ossified. Altered growth and subsequent deformity resulting from abnormal mechanical loading is often referred to as mechanical modulation of bone growth. This phenomenon has key implications in the progression of infant and juvenile musculoskeletal deformities, such as adolescent idiopathic scoliosis, hyperkyphosis, genus varus/valgus, tibia vara/ valga, as well as neuromuscular diseases and clinical management of these deformities is often directed at modifying the mechanical environment of affected bones. However, there is limited quantitative and physiological understanding of how bone growth is regulated in response to mechanical loading. This review of published work addresses the state of knowledge concerning key questions about the mechanisms underlying biomechanical modulation of bone growth. The longitudinal growth of bones is apparently controlled by modifying the numbers of growth plate chondrocytes in the proliferative zone, their rate of proliferation, the amount of chondrocytic hypertrophy and the controlled synthesis and degradation of matrix throughout the growth plate. These variables may be modulated to produce a change in growth rate in the presence of sustained or cyclic mechanical load. Tissue and cellular deformations involved in the transduction of mechanical stimuli depend on the growth plate tissue material properties that are highly anisotropic, time-dependent, and that differ in different zones of the growth plate and with developmental stages. There is little information about the effects of time-varying changes in volume, water content, osmolarity of matrix, etc. on differentiation, maturation and metabolic activity of chondrocytes. Also, the effects of shear forces and torsion on the growth plate are incompletely characterized. Future work on growth plate mechanobiology should distinguish between changes in the regulation of bone growth resulting from different processes such as direct stimulation of the cell nuclei, physicochemical stimuli, mechanical degradation of matrix or cellular components and possible alterations of local blood supply.Address for notification, correspondence and reprints: Isabelle Villemure, P.Eng., Ph.D., Department of Mechanical Engineering, Ecole Polytechnique of Montreal, P.O. Box 6079, Station "Centre-Ville", Montréal, Québec, H3C 3A7, CANADA, Phone: 1 (514) 340-4711 ext. 4900, Fax: 1 (514) 340-4176, E-mail: isabelle.villemure@polymtl.ca. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertai...

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Section: Growth Plate Behavior Under Mechanical Loadmentioning

confidence: 99%

Growth plate mechanics and mechanobiology. A survey of present understanding

Villemure

Stokes

2009

Journal of Biomechanics

197

160

View full text Add to dashboard Cite

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“…In earlier biomechanical studies, tensilc failure occurred in the Proliferating (13,20) or hypertrophic (6,8,20) Lone. In this study, the majority of the specimens failed at the hypertrophic zone adjacent to the proliferating zone.…”

Section: Discussionmentioning

confidence: 89%

“…The results ol previous biomechanical studies varied according to the species. the position of the growth plate, and the maturation of the animal (6,8,13,15,20). On the basis of the results of this study, differences in the microstructural tensilc properties may also be attributed to differences in the morphologic architecture and biochemical composition.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Microstructural Properties of the Distal Growth Plate of the Rabbit Radius and Ulna: Biomechanical, Biochemical, and Morphological Studies

Fujii¹,

Takai²,

Arai³

et al. 2000

The Journal of Bone and Joint Surgery-American Volume

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The purposes of this study were to define the tensile properties of each zone of the rabbit growth plate and to correlate them with the microarchitecture and biochemical composition of the zones. The epiphysis-growth plate-metaphysis complex was obtained from the radius and ulna of 20 8-week-old rabbits.Four dye markers were placed on thc growth plate. Thc complcx was loaded to failure with a tensilc testing machine, and the strain behavior was recordcd simultaneously with a microscope. a charge-couplcd device camera, and a video dimension-analyzer system. Thc collagenous fiber architecture of each zone was examined with a microscope. and the collagen content of each zone was also determined. The tangent modulus oP the resting zone was 75% stiffer than that of the other two zones. Thc highest values for strain at failure and energy absorbed to failure were observed in the hypertrophic zone. and the total collagen content was highest in the proliferating zone. The collagen fibers wcre more randomly aligned in the resting zonc than in the other two zones. The diversity observed in the microarchitecture of the rabbit growth plate correlates with the zone-dependent differences in its mechanical propertics. YoshidaM: [The effect of maturation on biomechanical properties of cpiphyseal plate in the rabbit.] J Kyoto Pref Univ Med 104:617-629, 1995

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“…In a study conducted on male New Zealand-California rabbits, Guse et al (1989) showed that the tensile mechanical properties of the distal femoral growth plate increase with animal age. In another study, it was reported that older bovine growth plates (12-18 months) were 25% thinner, 34% stronger and failed at 65% greater strain when compared to growth plates from 5 month old calves (Williams et al, 2001).…”

Section: Agementioning

confidence: 98%