2002
DOI: 10.1042/cs103s455s
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Effect of aging on gene expression rates of endothelin-1 and endothelin-2/vasoactive intestinal contractor in ethanol-induced gastric mucosal injury of the mouse

Abstract: To elucidate the physiological roles of endothelin-1 (ET-1) and endothelin-2 (ET-2)/vasoactive intestinal contractor (VIC) in gastric injury of mice, we measured the gene expression rates of ET-1 and ET-2/VIC in gastric injury induced by ethanol in young (8 weeks) and old (>33 weeks) mice. Mice that were fasted for 24 h were injected with absolute ethanol intragastrically and killed after 1 or 4 h of ethanol exposure. The size of the gastric lesions increased gradually after ethanol exposure and was at its gre… Show more

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Cited by 3 publications
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“…Because the PPET2 splicing variant observed in healthy cat stomach tissue produces no disruption of ET2 peptide synthesis, the functional effects of splicing on this gene may be of little physiological significance. However, given the fact that ET2 is implicated in the pathophysiology of gastric mucosal injury, with marked elevation of mRNA expression in situ [6], the question of whether any splicing that affects the regulation of bioactive ET2 production might occur in the injured cat stomach is still of interest. Further study to determine the mechanism for the regulation of ET2 synthesis via a splicing pathway is necessary.…”
mentioning
confidence: 99%
“…Because the PPET2 splicing variant observed in healthy cat stomach tissue produces no disruption of ET2 peptide synthesis, the functional effects of splicing on this gene may be of little physiological significance. However, given the fact that ET2 is implicated in the pathophysiology of gastric mucosal injury, with marked elevation of mRNA expression in situ [6], the question of whether any splicing that affects the regulation of bioactive ET2 production might occur in the injured cat stomach is still of interest. Further study to determine the mechanism for the regulation of ET2 synthesis via a splicing pathway is necessary.…”
mentioning
confidence: 99%