Effect of Aging on Fertility and Pregnancy

Maroulis, George

doi:10.1055/s-2007-1019407

Cited by 50 publications

(21 citation statements)

References 46 publications

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“…In the age group between 25-29 years there is 4-8% decline in fertility. 5,6 Most of the women with infertility presented in our study were in the 25-30 years of age also reported by others. 7,8 In the present study Patients with primary infertility after careful evaluation of male factors when subjected to diagnostic hysterolaparoscopy approximately 82% of patients found to have some pelvic pathology.…”

Section: Discussionsupporting

confidence: 56%

Role of hysterolaparoscopy for the evaluation of primary infertility: An experience from a tertiary care hospital

Pande

Dora

Pradhan

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONInfertility is one of the most common problem for which couple seeks medical attention. It is seen almost in 10-15% of the reproductive couple.1 Though there are various tests available for the evaluation of the patients with infertility, for the complete evaluation of pelvic pathology hysterolaparoscopy became the gold standard over the years. Ovulatory dysfunction accounts for 21% to 32%, tubal factor 14% to 26%, unexplained 8% to 30% and endometriosis accounts 4% to 6% of female infertility.2-4 Hysterolaparoscopy gives detailed and magnified view of uterine, adenexal, peritoneal and other intra-abdominal pathology. Consequently, milder degree of distal fimbrial pathology, endometriosis, and pelvic adhesions can be diagnosed and treated at the same time which was missed during a routine trans vaginal ultrasonography. The main objective of the study was to assess the role of diagnostic hysterolaparoscopy in the diagnosis and treatment of primary infertility patients. METHODSThis was a hospital based retrospective observational study. Medical records of all cases of primary infertility were retrieved and analyzed. This study was conducted ABSTRACT Background: Infertility is one of the most common problem for which couple seeks medical attention. The main objective of the study was to assess the role of diagnostic hysterolaparoscopy in the diagnosis and treatment of primary infertility patients. Methods: For this retrospective study, patient with the diagnosis of primary infertility were recruited. Patients admitted between the periods 2014 to 2016 were included. Pertinent data related to infertility were collected from the case records and entered in predesigned performa. Results: Patients with primary infertility 246 (82%) diagnosed to have pelvic pathology. The most common cause of infertility was ovarian 122 (36.63%), Uterine 66 (19.82%), tubal 84 (25.22%) and unexplained infertility in 103 (30.93%) women. Patients with PCOS 76 (22.82%) and endometriosis 46 (13.81%) treated with drilling and endometriotic cystectomy. In 32 (9.60%) of patients hysteroscopic cannulation was done. For distal tubal blockage fimbrioplasty was performed in 38 (11.41%) of women. Pelvic adhesions diagnosed in 26 (7.80%) women. patients diagnosed with uterine septum 42 (12.61%) required hysteroscopic septal resection. During the evaluation of infertility 70 (21%) of women diagnosed to have incidental pelvic pathology treated according to pathology. Conclusions: Hysterolaparoscopy is emerging as a valuable technique for complete assessment of female infertility and also helps in treatment according to the cause.

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Section: Discussionsupporting

confidence: 56%

Role of hysterolaparoscopy for the evaluation of primary infertility: An experience from a tertiary care hospital

Pande

Dora

Pradhan

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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“…Finally, previous studies of female fertility after IPAA have not examined the effect of patient age, which may have a profound influence on female reproductive ability. [6][7][8][9] The purpose of this study was to evaluate fertility in females who have had IPAA performed for UC at a North American tertiary care hospital and compare this with fertility before IPAA and fertility in females with UC managed nonoperatively. Furthermore, factors that may be associated with failure to become pregnant after surgery were investigated.…”

mentioning

confidence: 99%

Female Infertility After Ileal Pouch-Anal Anastomosis for Ulcerative Colitis

Johnson¹,

Richard²,

Ravid³

et al. 2004

Diseases of the Colon &Amp; Rectum

160

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“…However, the most important aspect of diminished ovarian reserve and associated decline in reproductive potential is that its onset is highly variable (Mosher and Pratt, 1990;1991;Maroulis, 1991). This means that functional ovarian age as reflected by basal FSH and estradiol concentrations can be discordant with biological age (Scott et al, 1989;Scott and Hofmann, 1995;Toner et al, 1991b;Cahill et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Dynamic measurements of serum inhibin B and estradiol: apredictive evaluation of ovarian response to gonadotrophin stimulation in the early stage of IVF treatment

Miao

Huang

2009

J. Zhejiang Univ. Sci. B

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Abstract:Objective: We dynamically measured serum inhibin B and estradiol in the early stage of hormonal stimulation to predict the ovarian response in in vitro fertilization (IVF) treatment. Methods: A total of 57 patients (<40 years of age) who underwent the first cycle of long protocol IVF or introcytoplasmic sperm injection (ICSI) treatment were included. Serum inhibin B, estradiol, follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels were measured four times: (1) on Day 3 of the menstrual cycle (basal); (2) on the day before the first administration of gonadotrophin (Gn) (Day 0); (3) on Day 1 of Gn therapy; and (4) on Day 5 of Gn therapy. Comparisons of these measurements with ovarian responses and pregnancy outcomes were made and analyzed statistically. Results: (1) On Day 1 and Day 5 of recombinant FSH (rFSH) stimulation, ovarian response, i.e., numbers of follicles, oocytes, fertilized oocytes, and embryos, had a positive correlation (r s =0.46~0.61, P=0.000) with raised inhibin B and estradiol concentrations, but a negative correlation (r s =−0.67~−0.38, P=0.000 or P<0.01) with total rFSH dose and total days of rFSH stimulation. (2) No significant variation (P>0.05) between the pregnant and non-pregnant groups on the basis of mean age or on all hormone concentrations at four times of the IVF cycle was observed. However, all the seven patients aged >35 years did not reach pregnancy. Conclusions: (1) Serum inhibin B and estradiol concentrations obtained shortly after Gn therapy may offer an accurate and early prediction of ovarian response; (2) Low levels of serum inhibin B and estradiol obtained shortly after Gn stimulation indicate the need for a longer period of Gn treatment and a higher daily dosage; (3) No obvious pregnancy difference among patients of age <35 years was found; however, IVF pregnancy outcome is significantly lower in women of age >35 years.

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Effect of Aging on Fertility and Pregnancy

Cited by 50 publications

References 46 publications

Role of hysterolaparoscopy for the evaluation of primary infertility: An experience from a tertiary care hospital

Role of hysterolaparoscopy for the evaluation of primary infertility: An experience from a tertiary care hospital

Female Infertility After Ileal Pouch-Anal Anastomosis for Ulcerative Colitis

Dynamic measurements of serum inhibin B and estradiol: apredictive evaluation of ovarian response to gonadotrophin stimulation in the early stage of IVF treatment

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