Effect of Aging on Erythropoietin Secretion in Male Rats

Wang, Ray Yau; Tsai, Shau‐Wei; Lu, Chien Chen; Shih, Hsi Chang; Chen, Yen Hao; Tung, Yuh Fan; Wang, Wee Fong; Wang, Shyi Wu; Wang, Paulus S.

doi:10.1093/gerona/51a.6.b434

Cited by 13 publications

(6 citation statements)

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“…Administration of EPO by continuous infusion ensured serum levels similar to those found in animals subjected to intermittent hypoxia [21]. Interestingly, we also observed a reduction of hemoglobin and hematocrit in saline treated animals but not in EPO treated rats within the first 72 hours after ischemia.…”

Section: Discussionsupporting

confidence: 79%

Post-ischemic continuous infusion of erythropoeitin enhances recovery of lost memory function after global cerebral ischemia in the rat

et al. 2013

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BackgroundErythropoietin (EPO) and its covalently modified analogs are neuroprotective in various models of brain damage and disease. We investigated the effect on brain damage and memory performance, of a continuous 3-day intravenous infusion of EPO, starting 20 min after a transient 10 minute period of global cerebral ischemia in the rat.ResultsWe found no effect on selective neuronal damage in the CA1 region of the hippocampus, neocortical damage and damage to the striatum assessed at 7 days after ischemia. Also, no differences were observed in sensori-motor scores between EPO treated and saline treated ischemic animals. In contrast, memory performance was significantly improved in the EPO treated group. Saline treated injured animals (n = 7) failed in a test assessing recovery of spatial memory (6/6 and 5/6), while EPO treated animals had few and none failures (0/7 and 1/7).ConclusionWe conclude that although post-ischemic treatment with EPO is not neuroprotective in a model of cardiac arrest brain ischemia, its markedly positive effect on brain plasticity and recovery of memory function warrants consideration as treatment of cardiac arrest patients.

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Section: Discussionsupporting

confidence: 79%

Post-ischemic continuous infusion of erythropoeitin enhances recovery of lost memory function after global cerebral ischemia in the rat

et al. 2013

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“…There is no evidence in the literature that older subjects should have a more pronounced response to hypoxia or to training. In animals, the response of erythropoietin to hypoxia is even attenuated with increasing age [52]. So the difference of less than 5 years should not influence the results of the present study.…”

Section: Limitationsmentioning

confidence: 68%

Erythropoiesis and Performance after Two Weeks of Living High and Training Low in Well Trained Triathletes

Dehnert

Hütler²,

Liu

et al. 2002

Int J Sports Med

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The purpose of our study was to evaluate hematologic acclimatization during 2 weeks of intensive normoxic training with regeneration at moderate altitude (living high-training low, LHTL) and its effects on sea-level performance in well trained athletes compared to another group of equally trained athletes under control conditions (living low - training low, CONTROL). Twenty-one triathletes were ascribed either to LHTL (n = 11; age: 23.0 +/- 4.3 yrs; VO 2 max: 62.5 +/- 9.7 [ml x min -1 x kg -1]) living at 1956 m of altitude or to CONTROL (n = 10; age: 18.7 +/- 5.6 yrs; VO 2 max: 60.5 +/- 6.7 ml x min -1 x kg -1) living at 800 m. Both groups performed an equal training schedule at 800 m. VO 2 max, endurance performance, erythropoietin in serum, hemoglobin mass (Hb tot, CO-rebreathing method) and hematological quantities were measured. A tendency to improved performance in LHTL after the camp was not significant (p < 0.07). Erythropoietin concentration increased temporarily in LHTL (Delta 14.3 +/- 8.7 mU x ml -1; p < 0.012). Hb tot remained unchanged in LHTL whereas was slightly decreased from 12.5 +/- 1.3 to 11.9 +/- 1.3g x kg -1 in CONTROL (p < 0.01). As the reticulocyte number tended to higher values in LHTL than in CONTROL, it seems that a moderate stimulation of erythropoiesis during regeneration at altitude served as a compensation for an exercise-induced destruction of red cells.

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“…The down-regulation of brain-derived neurotrophic factor during exposure to hypoxia, 48 chronic anemia, 49 and chronic hypertension 50 has also been documented, as has been the dependence of brain-derived neurotrophic factor recovery upon erythropoietin synthesis, 51 and an age-related impairment in erythropoietin response to hypoxia. 52 Finally, the tight dependence of erythropoietin synthesis upon HIF-2 α in the brain 53 more clearly defines just why mild hypoxia, or anemic hypoxia, might impact working memory and learning in a temporary fashion and why an age-dependent impairment in the ability to synthesize erythropoietin and brain-derived neurotrophic factor might further impact working memory and learning.…”

Section: Discussionmentioning

confidence: 99%

Acute Anemia Elicits Cognitive Dysfunction and Evidence of Cerebral Cellular Hypoxia in Older Rats with Systemic Hypertension

Bertout

Ratcliffe

et al. 2010

Anesthesiology

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Background Postoperative cognitive dysfunction occurs frequently after cardiac, major vascular, and major orthopedic surgery. Aging and hypertensive cerebrovascular disease are leading risk factors for this disorder. Acute anemia, common to major surgery, has been identified as a possible contributor to postoperative cognitive dysfunction. The effect of hypoxia upon cognition and the cellular and molecular processes involved in learning and memory has been well described. Cerebrovascular changes related to chronic hypertension may expose cells to increased hypoxia with anemia. Methods Young to aged spontaneously hypertensive rats underwent testing for visuospatial memory and learning in the Morris water maze, measurement of cerebral tissue oxygenation via tissue oxygen probe, and measurement of hypoxia-sensitive genes and proteins, under conditions of sham and experimental isovolemic anemia. Results Acute isovolemic anemia elicited evidence of aging-dependent visuospatial working memory and learning impairment. Isovolemic anemia did not result in cerebral tissue hypoxia, when measured via tissue oxygen probe. Evidence of cellular hypoxia was, however, identified in response to the anemic challenge, as hypoxia-sensitive genes and proteins were up-regulated. Importantly, cellular hypoxic gene responses were increased with anemia in an age-dependent manner in this model of aging with chronic hypertension. Conclusions In a translational model of chronic hypertension, clinically relevant levels of acute anemia were associated with an age-dependent visuospatial working memory and learning impairment that was matched by an age-dependent cellular sensitivity to anemic hypoxia. These data offer support for a possible link between anemic hypoxia and postoperative cognitive dysfunction in humans.

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Effect of Aging on Erythropoietin Secretion in Male Rats

Cited by 13 publications

References 0 publications

Post-ischemic continuous infusion of erythropoeitin enhances recovery of lost memory function after global cerebral ischemia in the rat

Post-ischemic continuous infusion of erythropoeitin enhances recovery of lost memory function after global cerebral ischemia in the rat

Erythropoiesis and Performance after Two Weeks of Living High and Training Low in Well Trained Triathletes

Acute Anemia Elicits Cognitive Dysfunction and Evidence of Cerebral Cellular Hypoxia in Older Rats with Systemic Hypertension

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