Effect of aging and dietary restriction on bile acid metabolism in rats

Ferland, Guylaine; Tuchweber, Béatriz; Perea, A.; Yousef, Ibrahim M.

doi:10.1007/bf02535757

Cited by 18 publications

(5 citation statements)

References 20 publications

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“…In fact, it has been shown that bile acid formation decreases with aging (Einarsson et al 1985;Parini et al 1999;Bertolotti et al 1993). Indeed, activities of 12α-hydroxylase and cholesterol 7α-hydroxylase were found to be reduced with aging in female Sprague-Dawley rats (Ferland et al 1989) and elderly patients (Bertolotti et al 1993), respectively. CR was demonstrated to reverse this age-related decline in bile acid formation (Ferland et al 1989), indicating that CR regulates specific enzymes within this pathway.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, activities of 12α-hydroxylase and cholesterol 7α-hydroxylase were found to be reduced with aging in female Sprague-Dawley rats (Ferland et al 1989) and elderly patients (Bertolotti et al 1993), respectively. CR was demonstrated to reverse this age-related decline in bile acid formation (Ferland et al 1989), indicating that CR regulates specific enzymes within this pathway. Indeed, increased attention is being focused on bile acids as major mediators of longevity associated with CR (Roux and Chartrand 2010;Ferbeyre 2010) and also with genetic mutations promoting longevity, such as the dwarf mouse (Gems 2007).…”

Section: Discussionmentioning

confidence: 99%

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Chronic caloric restriction partially protects against age-related alteration in serum metabolome

Guzman

Fahey

et al. 2012

AGE

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Calorie restriction (CR) remains the most robust metabolic intervention to extend lifespan and improve healthspan in several species. Using global and targeted mass spectrometry-based metabolomics approaches, here we show that chronic CR prevents age-related changes in specific metabolic signatures. Global metabolomic analysis using ultra-performance liquid chromatography-tandem mass spectrometry detected more than 7,000 metabolites in sera from ad-libitum-fed young, aged, and aged C57BL/6 mice maintained on 40 % CR. Multivariate statistical analysis of mass spectrometry data revealed a clear separation among the young, aged, and aged-CR mice demonstrating the potential of this approach for producing reliable metabolic profiles that discriminate based on age and diet. We have identified 168 discriminating features with high statistical significance (p≤0.001) and validated and quantified three of these metabolites using targeted metabolite analysis. Calorie restriction prevented the age-related alteration in specific metabolites, namely lysophosphatidylcholines (16:1 and 18:4), sphingomyelin (d18:1/12:0), tetracosahexaenoic acid, and 7α-dihydroxy-4-cholesten-3-one, in the serum. Pathway analysis revealed that CR impacted the age-related changes in metabolic byproducts of lipid metabolism, fatty acid metabolism, and bile acid biosynthesis. Our data suggest that metabolomics approach has the potential to elucidate the metabolic mechanism of CR's potential anti-aging effects in larger-scale investigations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Chronic caloric restriction partially protects against age-related alteration in serum metabolome

Guzman

Fahey

et al. 2012

AGE

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“…Zhang and Yang, 2016), and these are likely intricately related to the gut microbiome (Kübeck et al, 2016). Finally, it is important to take into consideration the species differences while extrapolating differences between humans and rodents where changes in bile acid composition and concentration have been reported (Ferland et al, 1989; Fu and Klaassen, 2013). …”

Section: Bile Acids and Obesitymentioning

confidence: 99%

Bile acids and bariatric surgery

Albaugh

Banan

Ajouz

et al. 2017

Molecular Aspects of Medicine

111

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Bariatric surgery, specifically Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG), are the most effective and durable treatments for morbid obesity and potentially a viable treatment for type 2 diabetes (T2D). The resolution rate of T2D following these procedures is between 40-80% and far surpasses that achieved by medical management alone. The molecular basis for this improvement is not entirely understood, but has been attributed in part to the altered enterohepatic circulation of bile acids. In this review we highlight how bile acids potentially contribute to improved lipid and glucose homeostasis, insulin sensitivity and energy expenditure after these procedures. The impact of altered bile acid levels in enterohepatic circulation is also associated with changes in gut microflora, which may further contribute to some of these beneficial effects. We highlight the beneficial effects of experimental surgical procedures in rodents that alter bile secretory flow without gastric restriction or altering nutrient flow. This information suggests a role for bile acids beyond dietary fat emulsification in altering whole body glucose and lipid metabolism strongly, and also suggests emerging roles for the activation of the bile acid receptors farnesoid x receptor (FXR) and G-protein coupled bile acid receptor (TGR5) in these improvements. The limitations of rodent studies and the current state of our understanding is reviewed and the potential effects of bile acids mediating the short-and long-term metabolic improvements after bariatric surgery is critically examined.

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“…The bile acids taurocholic acid and taurochenodeoxycholate showed a significant graded increase with rising CR. Increasing age is associated with reduced bile acid synthesis in rodents (Ferland et al, 1989) and in humans and is thought to be related to the growth hormone/IGF axis (Bertolotti et al, 2007). CR has been shown to reverse the decline in the bile acid synthesis pathway with age in female C57BL/6 mice (De Guzman et al, 2013).…”

Section: Increasing Bile Acids May Be Linked To the Control Of Metabomentioning

confidence: 99%

The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice

et al. 2017

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SummaryCalorie restriction (CR) remains the most robust intervention to extend lifespan and improve health span. Using a global mass spectrometry‐based metabolomic approach, we identified 193 metabolites that were significantly differentially expressed (SDE) in the livers of C57BL/6 mice, fed graded levels of CR (10, 20, 30 and 40% CR) compared to mice fed ad libitum for 12 h a day. The differential expression of metabolites also varied with the different feeding groups. Pathway analysis revealed that graded CR had an impact on carnitine synthesis and the carnitine shuttle pathway, sphingosine‐1‐phosphate (S1P) signalling and methionine metabolism. S1P, sphingomyelin and L‐carnitine were negatively correlated with body mass, leptin, insulin‐like growth factor‐ 1 (IGF‐1) and major urinary proteins (MUPs). In addition, metabolites which showed a graded effect, such as ceramide, S1P, taurocholic acid and L‐carnitine, responded in the opposite direction to previously observed age‐related changes. We suggest that the modulation of this set of metabolites may improve liver processes involved in energy release from fatty acids. S1P also negatively correlated with catalase activity and body temperature, and positively correlated with food anticipatory activity. Injecting mice with S1P or an S1P receptor 1 agonist did not precipitate changes in body temperature, physical activity or food intake suggesting that these correlations were not causal relationships.

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Effect of aging and dietary restriction on bile acid metabolism in rats

Cited by 18 publications

References 20 publications

Chronic caloric restriction partially protects against age-related alteration in serum metabolome

Chronic caloric restriction partially protects against age-related alteration in serum metabolome

Bile acids and bariatric surgery

The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice

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