Effect of ageing on the retinal vascular responsiveness to flicker light in glaucoma patients and in ocular hypertension

Gugleta, Konstantin; Türksever, Cengiz; Polunina, Anna; Orgül, Selim

doi:10.1136/bjophthalmol-2012-302779

Cited by 19 publications

(25 citation statements)

References 26 publications

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“…In addition to endothelial dysfunction, ischemia-induced oxidative stress may interfere with normal pericyte behavior during microvascular dysfunction. 25,26 The effects of aging on retinal vessels have also been reported from other recent studies. Kneser et al described a significant decrease in the overall arterial regulative amplitude -defined as the sum of the maximum percentage dilatation and the maximum percentage constriction-and a significant decrease in constriction with age.…”

Section: Discussionmentioning

confidence: 68%

Diameter of Retinal Vessels in Patients With Diabetic Macular Edema Is Not Altered by Intravitreal Ranibizumab (Lucentis)

Terai¹,

Haustein²,

Siegel³

et al. 2014

Retina

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Section: Discussionmentioning

confidence: 68%

Diameter of Retinal Vessels in Patients With Diabetic Macular Edema Is Not Altered by Intravitreal Ranibizumab (Lucentis)

Terai¹,

Haustein²,

Siegel³

et al. 2014

Retina

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“…Inclusion criteria were: best corrected visual acuity better than 20/25, refractive errors lower than 3 diopters of sphere and 2 diopters of cylinder, normal intraocular pressure (<18 mm Hg), normal appearance of the optic disc, normal visual field (the latter was examined with a SITA 24-2 standard test in all subjects using the Humphrey VF analyzer, HFA II 750-4.1 2005, Carl Zeiss Meditec Inc, USA), no significant ocular disease found by routine ophthalmological examination, no history of glaucoma in the family and/or systemic diseases with possible ocular involvement, such as diabetes. Controls were matched with patients for age and refractive error because these factors have been shown to influence OCT measurements2223. Moreover, because it has been shown that cigarette smoking leading to a significant increase in choroidal thickness up to 1 h after24, all the subjects had not smoked the hour before the examination.…”

Section: Methodsmentioning

confidence: 99%

Changes in Choroidal Thickness follow the RNFL Changes in Leber’s Hereditary Optic Neuropathy

Borrelli¹,

Triolo²,

Cascavilla³

et al. 2016

Sci Rep

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Leber’s hereditary optic neuropathy (LHON) is typically characterized by vascular alterations in the acute phase. The aim of this study was to evaluate choroidal changes occurring in asymptomatic, acute and chronic stages of LHON. We enrolled 49 patients with LHON, 19 with Dominant Optic Atrophy (DOA) and 22 healthy controls. Spectral Domain-Optical Coherence Tomography (SD-OCT) scans of macular and peripapillary regions were performed in all subjects, to evaluate macular and peripapillary choroidal thickness, and retinal nerve fiber layer (RNFL) thicknes. Macular and peripapillary choroidal thicknesses were significantly increased in the acute LHON stage. On the contrary, macular choroidal thickness was significantly reduced in the chronic stage. Furthermore, peripapillary choroidal thickness was decreased in chronic LHON and in DOA. Both RNFL and choroid had the same trend (increased thickness, followed by thinning), but RNFL changes preceded those affecting the choroid. In conclusion, our study quantitatively demonstrated the involvement of the choroid in LHON pathology. The increase in choroidal thickness is a feature of the LHON acute stage, which follows the thickening of RNFL. Conversely, thinning of the choroid is the common outcome in chronic LHON and in DOA.

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“…; Gugleta et al. ). Nevertheless, a more complex analysis of the dynamics of both vasodilation and vasoconstriction responses, as well as of the capacity to re‐establish a preflicker diameter after the cessation of stress, is needed for a better understanding of healthy individual vascular dynamics.…”

Section: Introductionmentioning

confidence: 96%

Ageing effect on flicker‐induced diameter changes in retinal microvessels of healthy individuals

Seshadri

Ekárt

Gherghel

2015

Acta Ophthalmologica

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PurposeTo compare flicker‐induced retinal vessel diameter changes in varying age groups with low cardiovascular risk.MethodsRetinal vascular reactivity to flicker light was assessed by means of dynamic retinal vessel analysis in 57 participants aged 19–30 years, 75 participants aged 31–50 years and 62 participants aged 51–70 years participants. Other assessments included carotid intima–media thickness (c‐IMT), augmentation index (AIx), blood pressure profiles, blood lipid metabolism markers and Framingham risk scores (FRS).ResultsRetinal arterial dilation amplitude (DA) and postflicker percentage constriction (MC%) were significantly decreased in the oldest group compared to the middle‐aged (p = 0.028; p = 0.021) and youngest group (p = 0.003; p = 0.026). The arterial constriction slope (SlopeAC) was also decreased in the oldest group compared to the youngest group (p = 0.027). On the venous side, MC% was decreased in the middle‐aged and oldest groups in comparison with the youngest group (p = 0.015; p = 0.010, respectively). Additionally, men exhibited increased arterial DA (p = 0.007), and percentage dilation (MD%, p < 0.001) in comparison with women, but only in the youngest age group. Both AIx and c‐IMT scores increased with age (both p < 0.001); however, no correlations were found between the observed differences in the measured retinal vascular function and systemic parameters.ConclusionIn individuals with low cardiovascular risk, there are age‐related differences in flicker‐induced retinal vessel diameter changes throughout the entire functional response curve for arteries and veins. Gender differences mainly affect the arterial dilatory phase and are only present in young individuals.

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Effect of ageing on the retinal vascular responsiveness to flicker light in glaucoma patients and in ocular hypertension

Cited by 19 publications

References 26 publications

Diameter of Retinal Vessels in Patients With Diabetic Macular Edema Is Not Altered by Intravitreal Ranibizumab (Lucentis)

Diameter of Retinal Vessels in Patients With Diabetic Macular Edema Is Not Altered by Intravitreal Ranibizumab (Lucentis)

Changes in Choroidal Thickness follow the RNFL Changes in Leber’s Hereditary Optic Neuropathy

Ageing effect on flicker‐induced diameter changes in retinal microvessels of healthy individuals

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