Effect of Age upon Hepatic Synthesis of Cholesterol in Rat.

Rosenman, Ray H.; Shibata, Eichi

doi:10.3181/00379727-81-19855

Cited by 17 publications

(3 citation statements)

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“…This average increase of approximately 19 rag. of cholesterol, representing an increase of almost 100 per cent, of course accounts for only a fraction of the amount of cholesterol absorbed but it must be remembered that undoubtedly a considerable amount of cholesterol also was converted into and excreted as cholic acid in these young rats, as previously demonstrated (29).…”

Section: B the Deposition Of Cholesterol In The Liver And Visceramentioning

confidence: 79%

Observations Concerning the Production and Excretion of Cholesterol in Mammals

Friedman

Byers

Shibata

1953

Journal of Experimental Medicine

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The absorption of oral cholesterol by rats was followed directly by analyses of the thoracic lymph and indirectly by calculating the deficit of fecal cholesterol under the amount fed. The two methods checked within about 20 per cent, with fecal analyses indicating the greater absorption. The absorbed cholesterol was found to be deposited in the liver, only very minor quantities being found in other organs or plasma. Bile is necessary for normal absorption of cholesterol, although very small amounts are absorbed even in its absence. Excess oral cholic acid increases the absorption of cholesterol by otherwise normal animals. The rat absorbs about 47 per cent of a single 50 mg. dose of cholesterol and about 34 per cent of a 100 mg. dose.

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Section: B the Deposition Of Cholesterol In The Liver And Visceramentioning

confidence: 79%

Observations Concerning the Production and Excretion of Cholesterol in Mammals

Friedman

Byers

Shibata

1953

Journal of Experimental Medicine

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“…Using isotope incorporation methods, Bloch et al [16] observed a striking decrease in the rate of cholesterol synthesis with age in rats. The output of cholesterol in the bile also decreased by 50 percent between 6 and 44 weeks of life [17]. We found that the acetyl-CoA carboxylase, aryl-CoA synthetase and triglyceride synthesizing activities in the liver were similar in young and old rats (data not shown).…”

Section: Discussionmentioning

confidence: 67%

Delayed Triglyceride Clearance from Blood in Aged Rats

Murano

Ishikawa

Nishide

et al. 1988

J. Clin. Biochem. Nutr.

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Plasma lipoprotein lipid, triglyceride clearance, and postheparin lipolytic activity were measured in young (2 months old) and aged (24 months old) male Wistar-King rats. Very low density lipoprotein and low density lipoprotein lipids (cholesterol, triglyceride, and phospholipid) and high density lipoprotein cholesterol were increased significantly in aged rats compared with the levels in young rats. Oral oil loading increased the plasma triglyceride levels to a greater extent in aged rats, and the clearance of plasma triglyceride following intravenously administered lipid occurred at a lower rate in the old rats. Lipoprotein lipase activities in post-heparin plasma and adipose tissue were higher in the young than that in the aged. These results suggest that hypertriglyceridemia in aged rats might be partly due to the delayed clearance of triglyceride by lipoprotein lipase.

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“…Bile cholesterol which drained directly to the exterior did not undergo this dilution and was perhaps more representative of newly synthesized liver cholesterol. Rosenman and associates (17,18) have also pointed out that the cholesterol which appears in the bile of their experimental animals represents newly synthesized sterol. A similar elevation in the specific activity of biliary cholesterol as compared with plasma cholesterol was reported by Gould and coworkers who administered labeled acetate to dogs with bile fistulas (19).…”

Section: Resultsmentioning

confidence: 99%

The Relation of Plasma and Biliary Cholesterol to Bile Acid Synthesis in Man *

Rosenfeld¹,

Hellman²

1959

J. Clin. Invest.

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Bile is an important excretory route of steroids since it contains cholesterol and bile acids which are derived from cholesterol. That cholic acid is formed from cholesterol was demonstrated by Bloch, Berg and Rittenberg over a decade ago (1). Other workers have confirmed this finding in animals (2-6) and the conversion has also been demonstrated in the human (7,8). Intermediates involved in this transformation have been extensively studied and reviewed by Bergstrom and Borgstrom (9, 10) and these workers have more recently reported on the stereochemical course of the transformation of cholesterol to cholic acid (11). This investigation deals with the dynamic aspects of the conversion of cholesterol of both endogenous and exogenous origins to cholic acid in man.Cholesterol-4-C14 and sodium acetate-H3 were fed to one subject, and sodium acetate-2-C14 was administered to a second subject; both had complete bile fistulas. It was found that orally ingested cholesterol and biosynthetic cholesterol mixed indistinguishably in the plasma after a short equilibration period. Plasma and biliary cholesterol had the same specific acivity and were in isotope equilibrium with the pool which served as the precuirsor of cholic acid. EXPERIMENTALClinical material. The subjects were hospitalized on a metabolic ward where complete collections of urine, feces and bile could be made. Subject A was a 58 year old white man who had an external bile fistula established surgically for the relief of a bile duct obstruction due to carcinoma of the pancreas. The completeness of the fistula was demonstrated by retrograde cholecystiography

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Effect of Age upon Hepatic Synthesis of Cholesterol in Rat.

Cited by 17 publications

References 0 publications

Observations Concerning the Production and Excretion of Cholesterol in Mammals

Observations Concerning the Production and Excretion of Cholesterol in Mammals

Delayed Triglyceride Clearance from Blood in Aged Rats

The Relation of Plasma and Biliary Cholesterol to Bile Acid Synthesis in Man *

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