Effect of age on the biomechanical and microcirculatory properties of the skin in healthy individuals and during venous ulceration

Mattar, Essam H.

doi:10.4103/0019-5154.77545

Cited by 5 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While the surgical site values followed a similar trajectory, the surgical site values were significantly higher at the 2 week time point suggestive of independent scar healing mechanisms. Consistent with prior studies, we noted that older age correlated with higher durometer readings 17 . Of the available surgical scales, the POSAS and MSS scar scales were selected for their demonstrated interobserver reliability and validity across multiple scar evaluation studies 16,18 …”

Section: Discussionsupporting

confidence: 57%

Baseline incision characteristics and early scar maturation indices following cardiac device implantation

Mehta

Morgaenko

Haines

et al. 2021

Journal of Arrhythmia

View full text Add to dashboard Cite

Aims Dermatologic evaluation for cardiac implantable electronic devices (CIEDs) has not been established. We sought to ascertain baseline wound scar features using quantifiable surgical tools and scar scales on post‐CIED patients. Methods A single‐center, prospective observational case‐control study was performed where 92 study subjects (40 healthy volunteers and 52 post‐CIED patients) completed the study. Durometer was used to quantify skin pliability before CIED placement, postprocedure, and 2 weeks postprocedure. Higher durometer readings signified reduced skin pliability. Durometer readings were compared to the patients’ contralateral pectoral skin and to a healthy volunteer's cohort skin within the prepectoral region. Patient wounds were observed and graded using the Patient Observer Scar Assessment Scale (POSAS) and Manchester Scar Scale (MSS). Results Baseline pectoral skin pliability readings were similar in healthy volunteers and CIED patient population. In comparison to preprocedural measurements, surgical site skin pliability decreased in postprocedural and 2 weeks follow‐up time points (P‐value .004 and <.001, respectively). The increases in durometer readings were higher in the older population (age >75 over time, P = .008). POSAS evaluations showed on average a thin painless hypopigmented scar with moderate stiffness. MSS scar evaluation showed a palpable scar with slight contour differences and color mismatch and appeared to be slightly better in the African American population. There was no difference in scar characteristics with preprocedural use of antiplatelet or anticoagulation or staple closure or gender. Conclusions Serial measurements could be of value for development of new strategies for cosmesis and improved wound healing.

show abstract

Section: Discussionsupporting

confidence: 57%

Baseline incision characteristics and early scar maturation indices following cardiac device implantation

Mehta

Morgaenko

Haines

et al. 2021

Journal of Arrhythmia

View full text Add to dashboard Cite

show abstract

“…DIA and DEA represent the effect of lymphedema after excluding the influence of age. 22,26 The values of a-Ith, DIA, a-Cth, and DEA are shown as median and interquartile range. The calculation method is summarized in Figure 3.…”

Section: Calculation Of Skin Induration and Elasticity Agementioning

confidence: 99%

Development of a Noninvasive Skin Evaluation Method for Lower Limb Lymphedema

Sano

Hirakawa

Yamanaka

et al. 2020

Lymphatic Research and Biology

View full text Add to dashboard Cite

Background: The skin's condition is altered in lymphedema patients, and evaluating this change is important. Some noninvasive methods for evaluating skin condition have been reported, especially in upper limb lymphedema. However, evaluating the skin in lower limb lymphedema remains challenging and is often limited to palpation. We aimed to develop a noninvasive skin evaluation method for lower limb lymphedema patients. Methods and Results: Twenty-five lower limb lymphedema patients were included. Skin induration and elasticity were measured using Indentometer Ò IDM 400 and Cutometer Ò MPA580. The relationship between the properties of skin from the healthy forearm and thigh, those of the affected thigh, and age was analyzed. Predicted skin induration age (IA) and elasticity age (EA) were calculated from the forearm, whereas actual values were calculated from the thigh, and the differences (DIA and DEA) were assessed. Patients were classified according to the International Society of Lymphology clinical staging system, and the differences in DIA and DEA were analyzed among the three groups (healthy, stage I/IIa, and stage IIb/III). Skin biopsy was performed in five unilateral lower limb lymphedema patients, and the dermal elastic fiber area was determined using microscopy with Elastica van Gieson staining. DEA significantly increased with disease progression, but DIA did not change significantly. Microscopy revealed elastic fiber filamentous changes, with decreased elastic fiber areas in lymphedema-affected skin. Conclusion: To our knowledge, this is the first report to evaluate lower limb skin elasticity in lymphedema quantitatively and noninvasively. DEA is useful for evaluating skin condition progression in lymphedema patients.

show abstract

“…The medical application of Durometer is related to skin studies in healthy subjects [10][11][12][13] and in patients with systemic scleroderma, 5,[14][15][16][17][18][19] localized scleroderma, 5,20-24 lipodermatosclerosis, [25][26][27][28][29][30] diabetic neuropathic foot, [31][32][33] hypertrophic scars, and keloids. [34][35][36][37][38] 2.…”

Section: Introductionmentioning

confidence: 99%

Use of a novel indentometer to evaluate skin stiffness in healthy and diseased human skin

Ivanova

Aleksiev

Dobrev

et al. 2023

Skin Research and Technology

View full text Add to dashboard Cite

Background: Mechanical behavior of the skin can be evaluated by different noninvasive methods. In this study, we applied a new measurement device based on indentometry to determine the skin mechanical properties in healthy individuals and in patients with systemic sclerosis (SSc). Material and methods:Three studies were performed. Study 1 included 100 healthy individuals (46 male and 54 female) divided into four age groups with mean ages of 21.5, 28.9, 51.2, and 69.3 years, respectively. Test sites were located on the center of the forehead and the middle of both volar forearms. Study 2 included 16 healthy individuals (two males and 14 females). Test sites were on both volar forearms. Measurements were made before and after the application of Vaseline and emulsion with 12% urea. Study 3 included 20 patients (one male and 19 females) with SSc and 60 agematched healthy individuals (23 males and 37 females). Test sites were on the center of the forehead and the middle of both volar forearms. Skin stiffness was measured with skin Indentometer IDM 800 (Courage + Khazaka, Cologne, Germany) equipped with two probes with pin diameters of 3 and 5 mm, respectively. The stiffer the skin, the less deep the displacement by the indenter. The smaller the diameter, the deeper the pin will go into the skin when using the same force. In addition, the Corneometer CM 820 (Courage + Khazaka) was used to determine epidermal water content in study 2. Results: Indentometric (IDM) values of healthy subjects measured with both probeswere lower on the forehead compared to volar forearms. There was no significant difference between both forearms. In all age groups, the IDM values on the male forearms were lower than on the female forearms whereas there was no significant difference on the forehead. In both sex and on all test locations a significant positive correlation between age and IDM values measured with both probes was observed. There was a significant positive correlation between IDM values measured with both probes.The application of moisturizers induced significant changes in epidermal water content whereas the IDM values remained unchanged. At both the forehead and volar forearms, the IDM values in patients with SSc were significantly lower compared to the healthy control skin.

show abstract

Effect of age on the biomechanical and microcirculatory properties of the skin in healthy individuals and during venous ulceration

Cited by 5 publications

References 26 publications

Baseline incision characteristics and early scar maturation indices following cardiac device implantation

Baseline incision characteristics and early scar maturation indices following cardiac device implantation

Development of a Noninvasive Skin Evaluation Method for Lower Limb Lymphedema

Use of a novel indentometer to evaluate skin stiffness in healthy and diseased human skin

Contact Info

Product

Resources

About