Effect of Age on Prognosis in Patients With Gastric Cancer

Saito, Hiroaki; Osaki, Tomohiro; Murakami, Daiki; Sakamoto, Teruhisa; Kanaji, Shingo; Tatebe, Shigeru; Tsujitani, Shunichi; Ikeguchi, Masahide

doi:10.1111/j.1445-2197.2006.03756.x

Cited by 67 publications

(60 citation statements)

References 13 publications

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“…Regarding lymph node involvement, if several reports did not show any significant difference in the rate of lymph node involvement (10,(28)(29)(30), other authors described a trend toward higher incidence of lymph node involvement in the elderly, although statistical significance was not reached (8,31); conversely in cases of early disease, several studies report lower prevalence of lymph node metastases in the elderly as compared to patients aged under 75 (7,27).…”

Section: Characteristics Of Gastric Cancer In the Elderlymentioning

confidence: 86%

Lymphadenectomy in elderly/high risk patients: should it be different?

Ruspi¹,

Galli²,

Pappalardo³

et al. 2017

Transl. Gastroenterol. Hepatol.

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Abstract:The global aging of population will lead a greater number of elderly patients to undergo surgical procedure in a near future. Concerning gastric cancer, the impact of lymphadenectomy on survival has been demonstrated in RCTs, and extended lymphadenectomy is now considered as gold standard of treatment in non-early tumors. However, the role of age as a prognostic factor and the benefit of extended surgery in elderly/high-risk patients are not clearly defined yet. From our revision of literature, it seems that surgery for gastric cancer may have a further tailorization, considering not only the stage of disease, but also patients' age and comorbidities.

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Section: Characteristics Of Gastric Cancer In the Elderlymentioning

confidence: 86%

Lymphadenectomy in elderly/high risk patients: should it be different?

Ruspi¹,

Galli²,

Pappalardo³

et al. 2017

Transl. Gastroenterol. Hepatol.

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“…Peritoneum invasion emerges infrequently [29][30][32][33]. This distinct pattern of metastases and recurrence observed in the elderly may be related to the higher prevalence of blood vessels invasion observed in that age group [1,30]. Regarding the incidence of lymph node metastases, observations are controversial.…”

Section: Patterns Of Metastases and Recurrencementioning

confidence: 99%

“…Regarding the incidence of lymph node metastases, observations are controversial. Several reports have revealed no significant difference in the rate of lymph node involvement [1,15,20,30], whereas few studies have demonstrated a trend toward higher incidence of lymph node metastases in the elderly, but not to a statistically significant extent [34]. In cases of early gastric cancer, numerous reports suggest a lower prevalence of lymph node metastases in the elderly as compared to younger patients (aged under 75) [14,16,35].…”

Section: Patterns Of Metastases and Recurrencementioning

confidence: 99%

See 1 more Smart Citation

Gastric cancer in the elderly: An overview

Saif

Makrilia

Zalonis

et al. 2010

European Journal of Surgical Oncology (EJSO)

138

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Aims: Gastric cancer in the elderly represents a distinct entity with specific clinicopathological characteristics and the majority of affected patients belong to this age group. Subtotal or total gastrectomy with radical lymph node dissection, adjuvant chemo-radiotherapy or perioperative chemotherapy represent the only potentially curative treatment options and seem to be performed with acceptable morbidity and mortality rates in selected elderly patients. Published research is very limited due to the strict selection and under-representation of elderly patients in clinical trials. A review of current recommendations and practice was performed.Methods: A comprehensive literature review was performed searching Medline for articles published since 1974, using "gastric cancer", "elderly" and "treatment" as key words.Observations: The data suggest that elderly patients that fulfill the inclusion criteria of clinical trials experience the same advantages and toxicities from chemotherapy as younger patients. Fit elderly patients with operable gastric cancer should be canndidates for the standard surgical resection provided that pre-operative comorbidities are taken into account. Peri-operative chemotherapy or post-operative chemoradiotherapy should be added in case of locally advanced disease. Palliative systemic chemotherapy seems to prolong survival in recurrent and metastatic disease.Conclusions: Chronological age alone is not sufficient reason to withhold curative or palliative treatment from an elderly gastric cancer patient. Performance status does not suffice in order to estimate the general condition of elderly patients and cofactors regarding their functional, social and mental status have to be considered.Word count (abstract): 234

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“…Some researchers thought that it was not an independent prognostic factor [38][39][40], whereas others thought that younger patients has worse prognoses than elderly due to the worse biological behaviors of tumors and histological type [41]. However, Saito et al held that elderly patients had worse prognosis because they had limited lymph node dissection and lower tolerance of chemotherapy [42].…”

Section: Agementioning

confidence: 99%