Effect of Age on Platelet 5-HT Concentrations in Healthy Controls, Depressed and Schizophrenic Patients

Mück‐Šeler, Dorotea; Bujas, Maja; Ljubic‐Thibal, Vesna; Jakovljević, Miro

doi:10.1159/000119311

Cited by 11 publications

(5 citation statements)

References 14 publications

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“…Platelet 5-HT concentration might be affected by sex, age or seasonality. The effect of sex was excluded with the inclusion of only male subjects; the possible effect of age on platelet 5-HT content was 6 6 neglected as no significant relation between age and platelet 5-HT was found in healthy (Muck-Seler et al, 1996b;Pivac et al, 2001;Pivac et al, 2004b) or PTSD (present study) subjects, and the possible seasonal influence on platelet 5-HT parameters (Jakovljevic et al, 1997) was avoided since war veterans and healthy controls were sampled in the same season.…”

Section: Discussionmentioning

confidence: 99%

Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms

Pivac

Kozarić‐Kovačić

Mustapić

et al. 2006

Journal of Affective Disorders

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Section: Discussionmentioning

confidence: 99%

Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms

Pivac

Kozarić‐Kovačić

Mustapić

et al. 2006

Journal of Affective Disorders

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“…Nonsuppressors with intermittentchronic time course of schizophrenia had significantly higher, while those with intermittent and chronic time course had marginally higher basal and postdexamethasone platelet 5-HT levels than suppressors. Our previously published data excluded the possibility that hyperserotonemia found in schizophrenic patients was a consequence of prior medication [12], platelet monoamine oxidase activity [23], age [15] or seasonal influence [24].…”

Section: Discussionmentioning

confidence: 88%

“…Platelets were sedimented by further centrifugation of PRP at 10,000 g for 5 min. Platelet 5-HT concentrations were determined by the spectrofluorimetric method, as described previously [15]. Platelet protein was determined by the method of Lowry et al [16].…”

Section: Methodsmentioning

confidence: 99%

Platelet 5-HT and Plasma Cortisol Concentrations after Dexamethasone Suppression Test in Patients with Different Time Course of Schizophrenia

et al. 1998

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Platelet 5-HT and plasma cortisol concentrations were determined in 59 schizophrenic patients with different time course of illness before and after dexamethasone suppression test (DST). An abnormal DST (nonsuppression) was observed in 51% of patients. In these patients basal cortisol and platelet 5-HT concentrations were higher than in patients with normal DST. After DST, plasma cortisol levels were higher in nonsuppressors with intermittent and intermittent-chronic time course, whereas platelet 5-HT concentrations were increased in nonsuppressors with intermittent-chronic time course. The results suggest that schizophrenic patients have dysregulated hypothalamic-pituitary-adrenal axis as shown by a high rate of DST nonsuppression, and that nonsuppressors showed hypercortisolemia and hyperserotonemia independent of the time course of schizophrenia. No significant association between DST and time course of the illness was found.

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“…, 191 , 193 One study, although underlying no difference between patients and controls, noted that higher platelet 5-HT concentrations were more evident in psychotic than in nonpsychotic patients. Furthermore, the lowest platelet 5-HT concentration was associated with the most severe self-aggressive behaviors (both suicidal attempts and completed suicides) 201 202 An exploratory study examined associations between cortisol parameters, platelet 5-HT content, and platelet activity markers (CD40, CD40L, and CD62P) in 19 patients with type 2 diabetes (T2DM) and untreated comorbid MDD, 24 T2DM patients, 21 patients with untreated MDD, and 25 age- and sex-matched healthy control subjects, by using HPLC with UV detection.…”

Section: Discussionmentioning

confidence: 97%

“…Furthermore, the lowest platelet 5-HT concentration was associated with the most severe self-aggressive behaviors (both suicidal attempts and completed suicides). 201,202 An exploratory study examined associations between cortisol parameters, platelet 5-HT content, and platelet activity markers (CD40, CD40L, and CD62P) in 19 patients with type 2 diabetes (T2DM) and untreated comorbid MDD, 24 T2DM patients, 21 patients with untreated MDD, and 25 age-and sexmatched healthy control subjects, by using HPLC with UV detection. Subgroups did not differ in 5-HT or cortisol slope, but in patients with both T2DM and MD, 5-HT and CD62P were positively correlated.…”

Section: Functional Studies On Platelet 5-ht Reuptakementioning

confidence: 99%

Is there a relationship between morphological and functional platelet changes and depressive disorder?

et al. 2020

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Background Blood platelets, due to shared biochemical and functional properties with presynaptic serotonergic neurons, constituted, over the years, an attractive peripheral biomarker of neuronal activity. Therefore, the literature strongly focused on the investigation of eventual structural and functional platelet abnormalities in neuropsychiatric disorders, particularly in depressive disorder. Given their impact in biological psychiatry, the goal of the present paper was to review and critically analyze studies exploring platelet activity, functionality, and morpho-structure in subjects with depressive disorder. Methods According to the PRISMA guidelines, we performed a systematic review through the PubMed database up to March 2020 with the search terms: (1) platelets in depression [Title/Abstract]”; (2) “(platelets[Title]) AND depressive disorder[Title/Abstract]”; (3) “(Platelet[Title]) AND major depressive disorder[Title]”; (4) (platelets[Title]) AND depressed[Title]”; (5) (platelets[Title]) AND depressive episode[Title]”; (6) (platelets[Title]) AND major depression[Title]”; (7) platelet activation in depression[All fields]”; and (8) platelet reactivity in depression[All fields].” Results After a detailed screening analysis and the application of specific selection criteria, we included in our review a total of 106 for qualitative synthesis. The studies were classified into various subparagraphs according to platelet characteristics analyzed: serotonergic system (5-HT2A receptors, SERT activity, and 5-HT content), adrenergic system, MAO activity, biomarkers of activation, responsivity, morphological changes, and other molecular pathways. Conclusions Despite the large amount of the literature examined, nonunivocal and, occasionally, conflicting results emerged. However, the findings on structural and metabolic alterations, modifications in the expression of specific proteins, changes in the aggregability, or in the responsivity to different pro-activating stimuli, may be suggestive of potential platelet dysfunctions in depressed subjects, which would result in a kind of hyperreactive state. This condition could potentially lead to an increased cardiovascular risk. In line with this hypothesis, we speculated that antidepressant treatments would seem to reduce this hyperreactivity while representing a potential tool for reducing cardiovascular risk in depressed patients and, maybe, in other neuropsychiatric conditions. However, the problem of the specificity of platelet biomarkers is still at issue and would deserve to be deepened in future studies.

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Effect of Age on Platelet 5-HT Concentrations in Healthy Controls, Depressed and Schizophrenic Patients

Cited by 11 publications

References 14 publications

Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms

Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms

Platelet 5-HT and Plasma Cortisol Concentrations after Dexamethasone Suppression Test in Patients with Different Time Course of Schizophrenia

Is there a relationship between morphological and functional platelet changes and depressive disorder?

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