Effect of Age on Normalized Small Solute Clearances in Men on Peritoneal Dialysis

Ah, Tzamaloukas; Gh, Murata

doi:10.1177/089686089901900119

Cited by 4 publications

(2 citation statements)

References 9 publications

(4 reference statements)

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“…Twardowski used the V/BSA ratio and reported that the mean V/BSA values are substantially higher in men than in women (24). A systematic analysis of the influences on the V/BSA ratio concluded that, in addition to gender, this ratio is affected by the degree of obesity and, in men only, by age (25,26). Figure2 shows these effects .…”

Section: Small Solute Clearances and Adequacy Of Pd-effect Of Bod Y Sizementioning

confidence: 99%

A 100-kg Man on Peritoneal Dialysis (PD) with a Borderline Kt/V: To PD or Not to PD

Tzamaloukas

Bunting²

2003

Perit Dial Int

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Section: Small Solute Clearances and Adequacy Of Pd-effect Of Bod Y Sizementioning

confidence: 99%

A 100-kg Man on Peritoneal Dialysis (PD) with a Borderline Kt/V: To PD or Not to PD

Tzamaloukas

Bunting²

2003

Perit Dial Int

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“…The use of two different size indicators (V, BSA) to normalize urea and creatinine clearance, respectively, causes significant distortions of the relationship between the two normalized clearances ( 14), although, in general, V and BSA correlate highly in PD patients (15). The distortions are caused by gender, degree of obesity, and, in men, age (16,17). Men have greater V than women with the same BSA.…”

Section: Problems Caused By the Use Of Two Different Size Indicatorsmentioning

confidence: 99%

Peritoneal Dialysis in Patients with Large Body Size: Can it Deliver Adequate Clearances?

Tzamaloukas

Murata

1999

Perit Dial Int

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Dependence of Peritoneal Clearances on Body Size in Continuous Ambulatory Peritoneal Dialysis: Effect of the Normalizing Size Indicator

Tzamaloukas

Murata²,

Malhotra³

2000

ASAIO Journal

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In peritoneal dialysis (PD), small solute clearances are normalized by body water (V) and body surface area (BSA). The purpose of this study was to identify if V or BSA produced stronger associations between body size and normalized clearances. We studied the relationship between four size indicators (V, BSA, height, and weight) and either peritoneal urea clearance normalized to V (Kt/V(ur)) and BSA (C(ur)) or creatinine clearance normalized to V (Kt/V(cr)) and BSA (C(cr)). A total of 613 clearance studies were performed in subjects on continuous ambulatory peritoneal dialysis (CAPD) with four daily exchanges and a 2 L fill volume. As size increased, the normalized peritoneal clearances decreased in a nonlinear fashion (regression: y = b0 + b1x(-1), where x is a size indicator and y is a normalized clearance). Significant (p < 0.001) negative correlations were found between each normalized clearance and each size indicator. However, in each case, the correlation was higher when V, rather than BSA, was used. For example, BSA correlated more closely with K/V(ur)(-0.660) than C(ur)(-0.556), and also with Kt/V(cr)(-0.579) than C(cr)(-0.446). Normalized clearances are smaller in large subjects on CAPD because one mathematic determinant of the clearance, the drain volume (Dv) normalized by V (Dv/V) or BSA (DV/BSA), decreases as size increases. The relationship between Dv/V or Dv/BSA and the size indicators was studied by the same nonlinear regression model. The correlations of the size indicators with Dv/V were also consistently higher than the corresponding correlations with Dv/BSA. In subjects who were on the same PD schedule, the dependence of clearances on size was consistently higher when V, rather than BSA, was the normalizing parameter. Because prescription of the dose of PD is based on body size, there is a practical advantage by using V as the sole normalizing parameter for both urea and creatinine clearance.

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Effect of Age on Normalized Small Solute Clearances in Men on Peritoneal Dialysis

Cited by 4 publications

References 9 publications

A 100-kg Man on Peritoneal Dialysis (PD) with a Borderline Kt/V: To PD or Not to PD

A 100-kg Man on Peritoneal Dialysis (PD) with a Borderline Kt/V: To PD or Not to PD

Peritoneal Dialysis in Patients with Large Body Size: Can it Deliver Adequate Clearances?

Dependence of Peritoneal Clearances on Body Size in Continuous Ambulatory Peritoneal Dialysis: Effect of the Normalizing Size Indicator

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