Effect of Age on Left Ventricular Global Dyssynchrony in Asymptomatic Individuals: A Population Study

Abstract

Normal aging is associated with worsening of LV global dyssynchrony shown by prolongation of isovolumic times resulting in shortening of filling and ejection times. Age also affects diastolic function as shown by E/A but not systolic function parameters, ejection fraction or stroke volume. Worsening of global dyssynchrony correlates with that of diastolic function but not with QRS duration.

Relationship between QRS measurements and left ventricular morphology and function in asymptomatic individuals

“…Also, irrespective of the mechanism for cavity dyssynchrony in our nonpathological cohort, QRS amplitude correlated with markers of dyssynchrony with values more than 9 s/min for T‐IVT and 0.3 for Tei index. We have previously shown that T‐IVT increases with age, as a sign of increased collagen deposition and subclinical dyssynchrony . Our current results confirm those findings in showing the other side of the coin which is the electric changes that correlate with signs of dyssynchrony in asymptomatics.…”

“…We have previously shown that T-IVT increases with age, as a sign of increased collagen deposition and subclinical dyssynchrony. 47 Our current results confirm those findings in showing the other side of the coin which is the electric changes that correlate with signs of dyssynchrony in asymptomatics. Finally, our findings show that while myocardial stretch and increase of cavity size prolongs specifically isovolumic contraction time and delays the start of cavity tension development and pressure rise, it is the increase in muscle mass that prolongs isovolumic relaxation time, the main determinant of dyssynchrony.…”

The significance of left ventricular ejection time in heart failure with reduced ejection fraction

“…29 Left ventricular dyssynchrony strongly correlates with IVCT. 30 As a result of the prolonged IVCT observed in LV dyssynchrony, LVET is shortened. 30 The MPI (IVCT + IVRT/LVET) has been shown to improve during cardiac resynchronization therapy.…”

Physical function and exercise training in older patients with heart failure

“…Normal ageing is associated with reduced physiological reserve capacity in a wide range of systems responsible for responses to aerobic and muscle resistance stimuli. The normal ageing process reduces cardiac function through several pathways, with a final common pathway being diminished diastolic function associated also with mild reductions in maximal systolic function 10,11 . An age-related decline in maximal heart rate has also been observed.…”