Effect of age on human neutrophil function

Wenisch, Christoph; Patruta, Sanda; Daxböck, Florian; Krause, Robert; Hörl, Walter H.

doi:10.1002/jlb.67.1.40

Cited by 376 publications

(283 citation statements)

References 39 publications

(38 reference statements)

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“…Chemotaxis (Fortin et al, 2006;Fulop et al, 2004) and phagocytosis (Butcher et al, 2001;Wenisch et al, 2000) is decreased in healthy aged individuals and in advanced age there is delayed cellular apoptosis during inflammatory responses (Fortin et al, 2007;Fulop et al, 1997;Tortorella et al, 2001;Tortorella et al, 2006). Studies of ROS production by neutrophils in the elderly have produced conflicting findings with some showing an increased production (De la Fuente, 2008;Ogawa et al, 2008) whereas others have reported decreased production of superoxide and hydrogen peroxide (Di Lorenzo et al, 1999;Fulop et al, 1985;Nagel et al, 1982).…”

Section: Neutrophils In Ageingmentioning

confidence: 99%

Nutrition, diet and immunosenescence

Maijó

Clements

Ivory

et al. 2014

Mechanisms of Ageing and Development

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Ageing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease. This complex process affects both the innate and adaptive immune systems with a progressive decline in most immune cell populations and defects in activation resulting in loss of function. Although host genetics and environmental factors, such as stress, exercise and diet can impact on the onset or course of immunosenescence, the mechanisms involved are largely unknown. This review focusses on identifying the most significant aspects of immunosenescence and on the evidence that nutritional intervention might delay this process, and consequently improve the quality of life of the elderly. We would like to thank the reviewers for their careful review of our manuscript, which has been revised accordingly. Below, we have provided a point-by-point reply to the issues raised: AbstractAgeing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease. This complex process affects both the innate and adaptive immune systems with a progressive decline in most immune cell populations and defects in activation resulting in loss of function. Although host genetics and environmental factors, such as stress, exercise and diet can impact on the onset or course of immunosenescence, the mechanisms involved are largely unknown. This review focusses on identifying the most significant aspects of immunosenescence and on the evidence that nutritional intervention might delay this process, and consequently improve the quality of life of the elderly.

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Section: Neutrophils In Ageingmentioning

confidence: 99%

Nutrition, diet and immunosenescence

Maijó

Clements

Ivory

et al. 2014

Mechanisms of Ageing and Development

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show abstract

“…For the innate system, there is a skewing of haematopoiesis towards the myeloid lineage (Beerman et al 2010), reduced functioning of neutrophils (Wenish et al 2000;Butcher et al 2001), NK cells (Hazeldine et al 2012) and monocytes upon challenge, although monocytes from old donors show increased cytokine secretion in the basal state (Hearps et al 2012). The latter contributes to another key feature of the aged systemic environment with increased levels of serum pro-inflammatory cytokines (IL6, TNFα, hsCRP) and lower levels of anti-inflammatory IL10, termed inflammageing (Franceschi and Bonafé 2003;Franceschi 2007).…”

Section: Mdscs Immunosenescence and Ageingmentioning

confidence: 99%

Ageing and myeloid-derived suppressor cells: possible involvement in immunosenescence and age-related disease

Bueno

Sant’Anna

Lord

2014

AGE

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Infections, cancer and autoimmune diseases occur more frequently in the elderly, and although many factors contribute to this, the age-related remodelling of the immune system, termed immunosenescence, plays a major role. Over the last two decades, studies have evaluated the effect of ageing on both the adaptive and innate arms of the immune system and demonstrated compromised function in several cells including lymphocytes (naïve, effector and memory), regulatory T and B cells, monocytes, neutrophils and NK cells. In addition, a well-documented feature of ageing is the increase in systemic inflammatory status (inflammageing), with raised serum levels of IL6, TNFα and CRP as well as reduced IL10. Recently, myeloid-derived suppressor cells have been the focus of many reports as these cells show immunosuppressive properties and are present in higher frequency during infections, cancer and autoimmunity. Importantly, there have been publications showing increased numbers of myeloid-derived suppressor cells in aged mice and humans. In this review, we discuss the current literature on myeloid-derived suppressor cells, their possible role in altered immune function in the elderly, and whether it may be possible to manipulate these cells to alleviate age-related immune dysfunction.

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“…Secondly, changes may be attributed to an impairment of neutrophil recruitment in the elderly, but literature is again contradictory: whereas Biasi and colleagues reported no differences in migration between elderly and young neutrophils in vivo [42], and Esparza et al found that the migratory response of PMN is also not affected by age [43]; other groups have reported reduced chemotaxis with increasing age [37,44,45]. Thirdly, ageinduced reduction in CNS neutrophil presence could also be attributed to a compromised function by an accelerated entry into apoptosis at the site of injury [46] as it is known that neutrophils have a short lifespan and die by apoptosis few hours after activation [47][48][49].…”

Section: Aged-induced Changes In Neutrophil Densitymentioning

confidence: 99%

Decreased myeloperoxidase expressing cells in the aged rat brain after excitotoxic damage

Campuzano¹,

Castillo-Ruiz²,

Acarín³

et al. 2011

Experimental Gerontology

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Brain aging is associated to several morphological and functional alterations that influence the evolution and outcome of CNS damage. Acute brain injury such as an excitotoxic insult induces initial tissue damage followed by associated inflammation and oxidative stress, partly attributed to neutrophil recruitment and the expression of oxidative enzymes such as myeloperoxidase (MPO), among others. However, to date, very few studies have focused on how age can influence neutrophil infiltration after acute brain damage. Therefore, to evaluate the age-dependent pattern of neutrophil cell infiltration following an excitotoxic injury, intrastriatal injection of Nmethyl-D-aspartate was performed in young and aged male Wistar rats. Animals were sacrificed at different times between 12 hours post-lesion (hpl) to 14 days post-lesion (dpl). Cryostat sections were processed for myeloperoxidase (MPO) immunohistochemistry, and double labeling for either neuronal cells (NeuN), astrocytes (GFAP), perivascular macrophages (ED-2), or microglia/macrophages (tomato lectin histochemistry). Our observations showed that MPO+ cells were observed in the injured striatum from 12 hpl (when maximum values were found) until 7 dpl, when cell density was strongly diminished. However, at all survival times analyzed, the overall density of MPO+ cells was lower in the aged versus the adult injured striatum. MPO+ cells were mainly identified as neutrophils (especially at 12 hpl and 1 dpl), but it should be noted that MPO+ neurons and microglia/macrophages were also found. MPO+ neurons were most commonly observed at 12 hpl and reduced in the aged. MPO+ microglia/macrophages were the main population expressing MPO from 3 dpl, when density was also reduced in aged subjects.These results point to neutrophil infiltration as another important factor contributing to the different response of the adult and aged brain to damage, highlighting the need of using aged animals for the study of acute agerelated brain insults.

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Effect of age on human neutrophil function

Cited by 376 publications

References 39 publications

Nutrition, diet and immunosenescence

Nutrition, diet and immunosenescence

Ageing and myeloid-derived suppressor cells: possible involvement in immunosenescence and age-related disease

Decreased myeloperoxidase expressing cells in the aged rat brain after excitotoxic damage

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