Effect of Age on Histological Changes of Urogenital Tract in Albino Rats

Al-hayyali, Fatima

doi:10.37940/ajvs.2020.13.1.10

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…We demonstrated that the bladder wall is a highly mechanical heterogeneous tissue, characterized by a gradient of stiffness from urothelium to lamina propria and muscle layer. We also showed an effect of aging on tissue mechanics, which is known to alter murine bladder histology 25 . Understanding tissue mechanics and the distribution corresponding to different anatomical tissue layers -as it was previously reported for organs as the cornea 26 or the skin 27 -is also of relevance for the bladder, as its physiological function comprehends high elastic tension and mechanical stress, and it may be crucial for bladder reconstruction purposes.…”

Section: Discussionmentioning

confidence: 64%

Micro-mechanical fingerprints of the rat bladder change in actinic cystitis and tumor presence

et al. 2023

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Tissue mechanics determines tissue homeostasis, disease development and progression. Bladder strongly relies on its mechanical properties to perform its physiological function, but these are poorly unveiled under normal and pathological conditions. Here we characterize the mechanical fingerprints at the micro-scale level of the three tissue layers which compose the healthy bladder wall, and identify modifications associated with the onset and progression of pathological conditions (i.e., actinic cystitis and bladder cancer). We use two indentation-based instruments (an Atomic Force Microscope and a nanoindenter) and compare the micromechanical maps with a comprehensive histological analysis. We find that the healthy bladder wall is a mechanically inhomogeneous tissue, with a gradient of increasing stiffness from the urothelium to the lamina propria, which gradually decreases when reaching the muscle outer layer. Stiffening in fibrotic tissues correlate with increased deposition of dense extracellular matrix in the lamina propria. An increase in tissue compliance is observed before the onset and invasion of the tumor. By providing high resolution micromechanical investigation of each tissue layer of the bladder, we depict the intrinsic mechanical heterogeneity of the layers of a healthy bladder as compared with the mechanical properties alterations associated with either actinic cystitis or bladder tumor.

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Section: Discussionmentioning

confidence: 64%

Micro-mechanical fingerprints of the rat bladder change in actinic cystitis and tumor presence

et al. 2023

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“…In Thi Qar city, a study of the parasitic and bacterial infections associated with appendicitis is carried out and reported four parasitic species; E. histolytica, G. lamblia, A. lumbricoids and E. vermicularis [11]. Another study in Samara district, also recorded four species E.histolytica, Entamoeba coli, E. vermicularis and Taenia saginata [12]. In Kirkuk city the parasitic infections associated with appendicitis aren't studied; according to the mentioned above the objective of the present study is the diagnosis of the parasitic infections in resected appendices in patients with appendicitis in Kirkuk city, in addition to determining its relationship with age, gender and stage of reported parasites species.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of parasitic infections in vermiform appendix in patients with appendicitis in Kirkuk city, Iraq

Al-Saeedi¹,

Al-Nasiri²

2019

Tikrit J. Pure Sci.

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The present study is conducted in Kirkuk city, Iraq; between July to December 2018. Within this period 197 resected appendix are examined to investigate the parasitic infections that may associated with appendicitis. Direct with concentrated methods are used in luminal content examinations. Also, histological examination of haematoxylin and eosin stained tissue sections is performed to diagnose the parasitic infections in the lumen and within the appendix tissue. The parasitic infection reported in 12.69% cases included four species, as well as a mixed infection. Entamoeba histolytica (trophozoite and cyst), Giardia lamblia (trophozoite and cyst), Cryptospordium sp.(oocyst) and Enterobious vermicularis (adult worm and ova) are recorded. The most common determined parasite is E. histolytica (8.63%). The parasitic infection within the resected appendix reported in females (8.12%) more than males (4.57%). The parasitic infections in the study are prevalent in patients within the age groups 13 to 18 years and 19 to 24 years (3.55% for each one).

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Effect of Age on Histological Changes of Urogenital Tract in Albino Rats

Cited by 2 publications

References 15 publications

Micro-mechanical fingerprints of the rat bladder change in actinic cystitis and tumor presence

Micro-mechanical fingerprints of the rat bladder change in actinic cystitis and tumor presence

Diagnosis of parasitic infections in vermiform appendix in patients with appendicitis in Kirkuk city, Iraq

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