Effect of age on gastric emptying of liquid-solid meals in man

Moore, John G.; Tweedy, Charles; Christian, Paul E.; Datz, Frederick L.

doi:10.1007/bf01324951

Cited by 201 publications

(68 citation statements)

References 10 publications

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“…The power ratio was significantly lower in the elderly groups, indicating that the postprandial gastric contractile force is reduced (hypomotility), resulting in a delay of gastric emptying in the elderly [20]. This delayed gastric emptying time was also demonstrated by the simultaneously delayed 13 CO 2 expiration peak time in the elderly.…”

Section: Discussionmentioning

confidence: 71%

Evaluation of Gastric Motor Activity in the Elderly by Electrogastrography and the <sup>13</sup>C-Acetate Breath Test

et al. 2002

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Background: Elderly people frequently have symptoms of fullness and appetite loss due to impaired gastric motor activity. These symptoms may cause malnutrition, immunosuppression and other complications. Objective: The effects of aging and daily activity on gastric motility in the elderly were investigated by electrogastrography and the ¹³C-acetate breath test. Methods: We enrolled seven active elderly subjects (active elderly group), seven elderly subjects staying at a geriatric facility who had reduced mental and physical capacities (inactive elderly group) and seven healthy young volunteers (young group). Electrogastrography was recorded before and after ingestion of a ¹³C-acetate-mixed liquid meal. Expired air was sampled every 10 min after the meal to measure the ¹³CO₂ concentration. Results: The ratio of the incidence of the 3-cpm wave (gastric intrinsic frequency) during the postprandial period compared to the fasting state was reduced in both elderly groups compared to young subjects, and the reduction was greater in the inactive elderly than in the active elderly group. The ratio of the amplitude of the peak frequency during the postprandial period to that in the fasting state (power ratio) was also lower in the elderly groups. The time of peak ¹³CO₂ expiration was delayed in the active elderly and more so in the inactive elderly group. Conclusion: Postprandial peristalsis and gastric contractile force are reduced in the elderly, and gastric emptying is delayed indicating a reduction in gastric motor activity.

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Section: Discussionmentioning

confidence: 71%

Evaluation of Gastric Motor Activity in the Elderly by Electrogastrography and the <sup>13</sup>C-Acetate Breath Test

et al. 2002

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“…Dysmotility in the gastrointestinal tract increases with ageing [1][2][3][4][5][6]. Constipation and faecal incontinence are common symptoms in the elderly [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Effect of Ageing on Colonic Endocrine Cell Population in Mouse

Sandström¹,

Mahdavi²

1998

Gerontology

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Background: Dysmotility in the gastrointestinal tract increases with age. Colonic endocrine cells play an important role in regulating intestinal secretion and motility. The objective was to study possible age-related changes in the colonic endocrine cells of an animal model. Methods: The colonic endocrine cells in four different age groups of mice were investigated by immunocytochemistry and quantified by computerized image analysis. The ages of these groups were 1, 3, 12 and 24 months old. Results: The numbers of peptide YY (PYY), enteroglucagon and serotonin immunoreactive (IR) cells in 1-month-old mice were significantly increased compared with those of 3-month-old mice. Similarly, the numbers of these cells were significantly greater in 12- and 24-month-old mice than in 3-month-old mice. The cell secretory index (CSI) of enteroglucagon and serotonin IR cells was higher in 1-, 12- and 24-month-old mice than in 3-month-old mice. There was no significant difference between the different age groups regarding the CSI of PYY IR cells, nor was there any statistical difference between females and males in all endocrine cell types regarding numbers and CSI. Conclusion: It is suggested that the increase in colonic endocrine cells prior to puberty might reflect the role of gut hormones in the development of the gastrointestinal tract. It is speculated further that the increase in colonic endocrine cells with ageing may compensate for increased receptor resistance and/or weakened response of effector organs. It is suggested that the increase in numbers and unchanged CSI of PYY cells with advancing age may be responsible for the slow colonic transit and constipation, both of which increase with age.

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“…This finding adds further support to the notion that age is possibly one of the factors that drives dyspeptic symptoms in peptic ulcer disease. However, it has been shown that age does not have a major influence on gastric emptying [41,42,43], and patients with uPUD were similar in age to the controls, yet had significantly delayed gastric emptying. Thus, age differences in this study are unlikely to affect the results of gastric emptying studies.…”

Section: Discussionmentioning

confidence: 99%

Complicated and Uncomplicated Peptic Ulcer Disease: Altered Symptom Response to a Nutrient Challenge Linked to Gastric Motor Dysfunction

et al. 2014

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Background: Bleeding peptic ulcer (BPU) frequently occurs in the absence of preceding dyspeptic symptoms. We have observed that patients with BPU had a diminished symptom response to nutrient challenge test compared to uncomplicated peptic ulcer disease (uPUD). We postulated that more symptoms are manifest in patients with uPUD than BPU because there are greater derangements in gastric motor function. Aim: To assess gastric emptying in patients with BPU, uPUD and healthy controls (HC). Methods: We studied 17 patients with BPU, 10 with uPUD, and 15 HC. After an 8-hour fast, subjects ingested 200 ml of an enteral feeding solution, containing 5 MBq ^99mTc-rhenium sulphide colloid, every 5 min up to a cumulative volume of 800 ml. Gastric emptying was measured by scintigraphy for the total, proximal and distal stomach. Results: Patients with uPUD had significantly higher gastric retention in the proximal and total stomach at 100 min than HC and BPU, while BPU had similar percent retention to HC. Patients with uPUD had significantly higher cumulative symptom response to the nutrient challenge than did HC and BPU, while BPU had similar symptom responses to HC. Conclusions: Patients with uPUD have significantly delayed gastric emptying compared to HC and BPU. Data suggest that in addition to alterations of visceral sensory function, altered gastric motor function occurs during a nutrient challenge in uPUD but not BPU. Gastric motor function may contribute to the manifestation of dyspeptic symptoms in PUD.

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Effect of age on gastric emptying of liquid-solid meals in man

Cited by 201 publications

References 10 publications

Evaluation of Gastric Motor Activity in the Elderly by Electrogastrography and the <sup>13</sup>C-Acetate Breath Test

Evaluation of Gastric Motor Activity in the Elderly by Electrogastrography and the <sup>13</sup>C-Acetate Breath Test

Effect of Ageing on Colonic Endocrine Cell Population in Mouse

Complicated and Uncomplicated Peptic Ulcer Disease: Altered Symptom Response to a Nutrient Challenge Linked to Gastric Motor Dysfunction

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