Effect of age on biochemical recurrence after radical prostatectomy

Özden, Cüneyt; Aktaş, Binhan Kağan; Bulut, Süleyman; Erbay, Güven; Tagci, Suleyman; Gökkaya, Cevdet Serkan; Baykam, Mehmet Murat; Memiş, Ali

doi:10.1016/j.kjms.2016.11.002

Cited by 7 publications

(3 citation statements)

References 25 publications

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“…Stephenson et al (22) validated two groups of patients and had summarized similar postoperative C-index value (0.81 vs. 0.79). Ozden et al (23) recruited 305 patients and concluded that age was not a significant factor to predict BRC, which was similar to our study. Freedland et al (24) found that the percentage of biopsy cores involvement by cancer was a better predictor than the number of cores involved by cancer.…”

Section: Discussionsupporting

confidence: 91%

Prediction of Postprostatectomy Biochemical Recurrence Using Quantitative Ultrasound Shear Wave Elastography Imaging

et al. 2019

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Objectives: To determine the prognostic significance of tissue stiffness measurement using transrectal ultrasound shear wave elastography in predicting biochemical recurrence following radical prostatectomy for clinically localized prostate cancer. Patients and Methods: Eligible male patients with clinically localized prostate cancer and extraperitoneal laparoscopic radical prostatectomy between November 2013 and August 2017 were retrospectively selected. Information of potential biochemical recurrence predictors, including imaging (ultrasound shear wave elastography and magnetic resonance imaging), clinicopathological characteristics, and preoperative prostate specific antigen (PSA) levels were obtained. Recurrence-free survival (Kaplan–Meier curve) and a multivariate model were constructed using Cox regression analysis to evaluate the impact of shear wave elastography as a prognostic marker for biochemical recurrence. Results: Patients experienced biochemical recurrence in an average of 26.3 ± 16.3 months during their follow-up. A cutoff of 144.85 kPa for tissue stiffness measurement was estimated for recurrence status at follow-up with a sensitivity of 74.4% and a specificity of 61.7%, respectively ( p < 0.05). In univariate analysis, shear wave elastography performed well in all preoperative factors compared to biopsy Gleason Score, PSA and magnetic resonance imaging; in multivariate analysis with postoperative pathological factors, shear wave elastography was statistically significant in predicting postoperative biochemical recurrence, which improved the C-index of predictive nomogram significantly (0.74 vs. 0.70, p < 0.05). Conclusions: The study revealed that quantitative ultrasound shear wave elastography-measured tissue stiffness was a significant imaging marker that enhanced the predictive ability with other clinical and histopathological factors in prognosticating postoperative biochemical recurrence following radical prostatectomy for clinically localized prostate cancer.

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Section: Discussionsupporting

confidence: 91%

Prediction of Postprostatectomy Biochemical Recurrence Using Quantitative Ultrasound Shear Wave Elastography Imaging

et al. 2019

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“…In a study of 305 patients investigating the effect of patient age on BCR after RP, no significant relationship was found between age and recurrence (24). Besides, Kunz et al evaluated the tumor characteristics of patients over the age of 70, which showed that patients in this age group had more biologically aggressive tumors than younger patients, but age alone was not an independent marker of survival after RP (25).…”

Section: Discussionmentioning

confidence: 99%

Cribriform glands are associated with worse outcome than other pattern 4 subtypes: A study of prognostic and clinicopathologic characteristics of prostate adenocarcinoma with an emphasis on grade groups

Gün¹,

Ocal²

2021

Preprint

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Aim: Although prostate adenocarcinoma is the most common cancer in men, survival is quite high and with the help of histopathological examination using the updated classification, patient management strategies are developing. We aimed to evaluate the correlation between the histopathological features and biochemical recurrence (BCR) in patients who underwent radical prostatectomy (RP) using the new classification. Methods: A total of 285 prostate adenocarcinoma cases that underwent RP between January 2009 and December 2017 and followed up for at least 3 months were included in the study. The cases were re-evaluated according to WHO-ISUP 2016 classification and the findings were recorded. Results: The mean age was 63,4 years. Gleason scores of the cases were as follows: 3+3 144 cases (50.5%), 3+4 81 cases (28.4%), 4+3 28 cases (9.8%), 4+4 7 cases (2.5%) , 3+5 6 cases (2.1%), 5+3 2 cases (0.7%), 4+5 17 cases (6%). There were 198 (69,5%) pT2, 54 (18,9%) pT3a and 33 (11,6%) pT3b cases. The mean follow-up time was 44,1 months and BCR was detected in 97 cases (34%). The relationship between the Group Grades and BCR was statistically significant. BCR rate increased as the tumor volume and the percentage of pattern 4 increased (p<0.001).There was a significant correlation between preoperative PSA value, extraprostatic extension, seminal vesicle invasion, surgical margin positivity, tumor volume, pattern 4 percentage, presence of cribriform glands and BCR and recurrence-free survival in both univariate and multivariate analysis and recurrence-free survival was also affected by these parameters. Among the morphological subtypes of Pattern 4, recurrence-free survival decreased as the incidence of cribriform glands increased (p <0.001). Conclusion: Histopathological evaluation is important in predicting BCR in prostate adenocarcinoma, the Group Grade system seems to be helpful in this regard. More studies are needed to prove the relatively worse prognostic effect of cribriform glands.

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“…22,23 In a study of 305 patients investigating the effect of patient age on BCR after RP, no significant relationship was found between age and recurrence. 24 Besides, Kunz et al evaluated the tumour characteristics of patients over the age of 70, which showed that patients in this age group had more biologically aggressive tumours than younger patients, but age alone was not an independent marker of survival after RP. 25 Also in our study, no significant relationship was found between age and BCR, and RFS (P = .974).…”

Section: Discussionmentioning

confidence: 99%

Cribriform glands are associated with worse outcome than other pattern 4 subtypes: A study of prognostic and clinicopathological characteristics of prostate adenocarcinoma with an emphasis on Grade Groups

Gün

Ocal

2021

Int J Clin Pract

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Aim: Although prostate adenocarcinoma is the most common cancer in men, survival is quite high and with the help of histopathological examination using the updated classification, patient management strategies are developing. We aimed to evaluate the correlation between the histopathological features and biochemical recurrence (BCR) in patients who underwent radical prostatectomy (RP) using the new classification.Methods: A total of 285 prostate adenocarcinoma cases that underwent RP between January 2009 and December 2017 and followed up for at least 3 months were included in the study. The cases were re-evaluated according to WHO-ISUP 2016 classification and the findings were recorded. Results:The mean age was 63,4 years. Gleason scores of the cases were as follows:3+3 144 cases (50.5%), 3+4 81 cases (28.4%), 4+3 28 cases (9.8%), 4+4 7 cases (2.5%) , 3+5 6 cases (2.1%), 5+3 2 cases (0.7%), 4+5 17 cases (6%). There were 198 (69,5%) pT2, 54 (18,9%) pT3a and 33 (11,6%) pT3b cases. The mean follow-up time was 44,1 months and BCR was detected in 97 cases (34%). The relationship between the Group Grades and BCR was statistically significant. BCR rate increased as the tumour volume and the percentage of pattern 4 increased (P < .001).There was a significant correlation between preoperative PSA value, extraprostatic extension, seminal vesicle invasion, surgical margin positivity, tumour volume, pattern 4 percentage, presence of cribriform glands and BCR and recurrence-free survival in both univariate and multivariate analysis and recurrence-free survival was also affected by these parameters. Among the morphological subtypes of Pattern 4, recurrence-free survival decreased as the incidence of cribriform glands increased (P < .001). Conclusion:Histopathological evaluation is important in predicting BCR in prostate adenocarcinoma, the Group Grade system seems to be helpful in this regard. More studies are needed to prove the relatively worse prognostic effect of cribriform glands.How to cite this article: Gun E, Ocal I. Cribriform glands are associated with worse outcome than other pattern 4 subtypes:A study of prognostic and clinicopathological characteristics of prostate adenocarcinoma with an emphasis on Grade Groups.

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Effect of age on biochemical recurrence after radical prostatectomy

Cited by 7 publications

References 25 publications

Prediction of Postprostatectomy Biochemical Recurrence Using Quantitative Ultrasound Shear Wave Elastography Imaging

Prediction of Postprostatectomy Biochemical Recurrence Using Quantitative Ultrasound Shear Wave Elastography Imaging

Cribriform glands are associated with worse outcome than other pattern 4 subtypes: A study of prognostic and clinicopathologic characteristics of prostate adenocarcinoma with an emphasis on grade groups

Cribriform glands are associated with worse outcome than other pattern 4 subtypes: A study of prognostic and clinicopathological characteristics of prostate adenocarcinoma with an emphasis on Grade Groups

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