Effect of Age on Allergen-induced Structural Airway Changes in Brown Norway Rats

Palmans, Els; Vanacker, Nele J.; Pauwels, Romain; Kips, Johan

doi:10.1164/rccm.2109011

Cited by 9 publications

(11 citation statements)

References 38 publications

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“…In a similar study, when 4-and 13-wk-old rats were compared, the younger animals had more pronounced airway functional alterations and inflammatory changes, supporting increased susceptibility at a younger age (10). In other reports, aged dogs, rats, rabbits, and mice showed a significant impairment in the generation of Th2-type allergic responses (11, 30 -34), as demonstrated in this study.…”

Section: Discussionsupporting

confidence: 89%

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Induction and Maintenance of Airway Responsiveness to Allergen Challenge Are Determined at the Age of Initial Sensitization

Gelfand

Joetham

Cui

et al. 2004

The Journal of Immunology

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Age is an important factor in determining the quantity and quality of immune responses when challenged with allergen. In a model of allergen-induced airway hyperresponsiveness and inflammation, where the sensitization phase and challenge phases can be dissociated in time, we examined the impact of age on these two phases. Sensitization of young mice (1–20 wk), but not older animals (30–40 wk), led to the development of airway hyperresponsiveness, airway eosinophilia, Th2 cytokine responses, and allergen-specific IgE, regardless of the age when the challenge phase was conducted. Thus, age at the time of initial sensitization was shown to be the critical factor dictating the nature of the response to later allergen challenge, as older mice remained responsive to allergen challenge if sensitized at a young age. These effects were shown to be mediated by lung T cells from sensitized young mice. Moreover, the failure of old sensitized mice to mediate these effects was shown not to be the result of active suppression of the responses. These data define the importance of age at initial allergen exposure in dictating subsequent responses in the lung when exposed to allergen and may help to define why asthma, even in adults, is most often initiated in early childhood.

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Section: Discussionsupporting

confidence: 89%

“…In the mouse there is support for these ideas based on the demonstration of defective generation of memory T cells in older mice (8) and that naive CD4 T cell function also dramatically declines with age (9). The responses to various stimuli (10,11) and the rate of repair (12)(13)(14) may also show a degree of age dependency.…”

mentioning

confidence: 99%

Induction and Maintenance of Airway Responsiveness to Allergen Challenge Are Determined at the Age of Initial Sensitization

Gelfand

Joetham

Cui

et al. 2004

The Journal of Immunology

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“…In young animals, highly significant WAt/Pbm differences were found in the small and medium IA, while in adult rats the medium and predominantly large IA differed from controls in terms of this parameter. This result is very similar to the findings of Palmans et al [18], who evaluated large IA exclusively and found a significant WAt/Pbm increase only in adult rats.…”

Section: Discussionsupporting

confidence: 92%

“…Fewer authors, however, have attempted to produce a model of chronic bronchial asthma with wall remodeling [17]. There is, to our knowledge, only one paper describing the differences in remodeling changes in two animal age groups and thus simulating developing asthma in children [18]. That study showed more pronounced airway remodeling at a young age; nevertheless, the authors examined only large airways.…”

Section: Introductionmentioning

confidence: 99%

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Airway Wall Remodeling in Young and Adult Rats with Experimentally Provoked Bronchial Asthma

Uhlı́k¹,

Šimůnková²,

Žaloudíková

et al. 2014

Int Arch Allergy Immunol

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Background: Airway wall remodeling is a typical finding in patients suffering from bronchial asthma. While morphological changes have been thoroughly described in adults, less is known about such changes in children because of the limited accessibility of relevant material. To overcome this constraint, animal asthma models may be used instead of human specimens. This study examined rats with artificially stimulated chronic asthma-like symptoms. Methods: Brown Norway rats of two age categories (young and adult) were sensitized by ovalbumin (OA), and their intrapulmonary airways (IA) were studied using morphometric and histochemical methods. Results: OA administration induced a significant increase in lung resistance in young animals but not in adults. The total IA wall area was significantly increased in both young and adult OA rats. In young animals, thickening of the adventitia played a more crucial role in this increase than it did in adults, in which the mucosa and the submucosa participated to a higher degree. The IA walls of young OA rats had significantly higher levels of infiltrating eosinophils than those of adult OA animals. The multiplication of goblet cells was more pronounced in adult rats, which was associated with a tendency to produce a higher proportion of acidic glycoconjugates. Conclusions: OA stimulation affected the IA of young rats differently than those of adult animals. Changes in the outer IA layer of young rats can be triggered by activated eosinophils; however, stimulated airway epithelium can be a source of factors that influence the inner IA layers in adult rats.

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Experimental approaches to evaluate respiratory allergy in animal models

Pauluhn

Möhr

2005

Experimental and Toxicologic Pathology

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Effect of Age on Allergen-induced Structural Airway Changes in Brown Norway Rats

Cited by 9 publications

References 38 publications

Induction and Maintenance of Airway Responsiveness to Allergen Challenge Are Determined at the Age of Initial Sensitization

Induction and Maintenance of Airway Responsiveness to Allergen Challenge Are Determined at the Age of Initial Sensitization

Airway Wall Remodeling in Young and Adult Rats with Experimentally Provoked Bronchial Asthma

Experimental approaches to evaluate respiratory allergy in animal models

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