Effect of age, breed and dietary omega-6 (n-6):omega-3 (n-3) fatty acid ratio on immune function, eicosanoid production, and lipid peroxidation in young and aged dogs

Kearns, Robert J.; Hayek, Michael G.; Turek, John; Meydani, Mohsen; Burr, John; Greene, Robert J.; Marshall, Craig A.; Adams, S. M.; Borgert, Robert C; Reinhart, Gregory A.

doi:10.1016/s0165-2427(99)00052-5

Cited by 71 publications

(58 citation statements)

References 43 publications

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“…Nevertheless, canine macrophages in allergic reactions are low IFNγ producers and synthesize IL-4 (Fujiwara et al 2003); this makes them similar to mouse M2 macrophages. Moreover, the blunted inflammatory activation of canine macrophages in response to adenosine and ATP (Fujimoto et al 2012) and the increased prostaglandin production in response to ω-3 fatty acids (Kearns et al 1999) resemble features of mouse M2 macrophages.…”

Section: Discussionmentioning

confidence: 95%

Adipose tissue macrophages in non-rodent mammals: a comparative study

et al. 2015

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The stromal vascular fraction (SVF) of adipose tissue in rodents and primates contains mesenchymal stem cells and immune cells. SVF cells have complex metabolic, immune and endocrine functions with biomedical impact. However, in other mammals, the amount of data on SVF stem cells is negligible and whether the SVF hosts immune cells is unknown. In this study, we show that the SVF is rich in immune cells, with a dominance of adipose tissue macrophages (ATMs) in cattle (Bos primigenius taurus), domestic goat (Capra aegagrus hircus), domestic sheep (Ovis aries), domestic cat (Felis catus) and domestic dog (Canis familiaris). ATMs of these species are granulated lysosome-rich cells with lamellipodial protrusions and express the lysosome markers acid phosphatase 5 (ACP-5) and Mac-3/Lamp-2. Using ACP-5 and Mac-3/Lamp-2 as markers, we additionally detected ATMs in other species, such as the domestic horse (Equus ferus caballus), wild boar (Sus scrofa) and red fox (Vulpes vulpes). Feline and canine ATMs also express the murine macrophage marker F4/80 antigen. In the lean condition, the alternative macrophage activation marker CD206 is expressed by feline and canine ATMs and arginase-1 by feline ATMs. Obesity is associated with interleukin-6 and interferon gamma expression and with overt tyrosine nitration in both feline and canine ATMs. This resembles the obesity-induced phenotype switch of murine and human ATMs. Thus, we show, for the first time, that the presence of ATMs is a general trait of mammals. The interaction between the adipose cells and SVF immune cells might be evolutionarily conserved among mammals.

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Section: Discussionmentioning

confidence: 95%

Adipose tissue macrophages in non-rodent mammals: a comparative study

et al. 2015

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“…This shift in FA ratio has been associated with an increase in a number of disorders including inflammatory diseases such as cardiovascular disease, arthritis, psoriasis and colitis (Kearns et al, 1999;McDaniel et al, 2010), and various neuroendocrine conditions such as childhood developmental disorders (Schuchardt et al, 2010), adult depression (Riemer et al, 2010), anxiety (Yehuda et al, 2005) and loss of cognitive function (Muldoon et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary fish meal and soybean meal on the ovine innate and acquired immune response during pregnancy and lactation

Stryker

Fisher

You

et al. 2013

Animal

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In recent years, livestock producers have been supplementing animal diets with fish meal (FM) to produce value-added products for health conscious consumers. As components of FM have unique neuroendocrine-immunomodulatory properties, we hypothesize that livestock producers may be influencing the overall health of their animals by supplementing diets with FM. In this study, 40 pregnant ewes were supplemented with rumen protected (RP) soybean meal (SBM: control diet) or RP FM, commencing gestation day 100 (gd100), in order to evaluate the impact of FM supplementation on the innate and acquired immune response and neuroendocrine response of sheep during pregnancy and lactation. On gd135, half the ewes from each diet (n 5 10 FM, n 5 10 SBM) were challenged iv with lipopolysaccharide (LPS) to simulate a systemic bacterial infection and the febrile, respiratory and neuroendocrine responses were monitored over time; the other half (n 5 10 FM, n 5 10 SBM) of the ewes received a saline injection as control. On lactation day 20 (ld20), all ewes ( n 5 20 FM, n 5 20 SBM) were sensitized with hen egg white lysozyme (HEWL) and the serum haptoglobin (Hp) response was measured over time. The cutaneous hypersensitivity response (CHR) to HEWL challenge was measured on ld30 ( n 5 20 FM, n 5 20 SBM), and blood samples were collected over time to measure the primary and secondary immunoglobulin G (IgG) response to HEWL. There was an attenuated trend in the LPS-induced febrile response by the FM treatment when compared with the SBM treatment ( P 5 0.06), as was also true for the respiratory response (P 5 0.07), but significant differences in neuroendocrine function (serum cortisol and plasma ACTH) were not observed between treatments. Basal Hp levels were significantly lower in the FM supplemented ewes when compared with the SBM supplemented ewes ( P , 0.01), and the Hp response to HEWL sensitization differed significantly over time between treatments (P , 0.01). The CHR to HEWL was also significantly attenuated in the FM treatment compared with the SBM (P , 0.01); however, treatment differences in the primary and secondary IgG responses to HEWL were not observed. These results indicate that FM supplementation differentially affects the innate and acquired immune responses in pregnant and lactating sheep compared with a typical SBM diet of commercial flocks. The long-term implications of this immunomodulation warrant further investigation.

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“…In vitro, mononuclear cells of older dogs were less responsive to stimuli than those of young dogs; however, there was no difference in production of inflammatory mediators in response to lipopolysaccharide between young and old dogs. 34 In addition, it is generally recognized that an increased risk of infectious disease is a feature of young dogs rather than senior ones. When in vivo assessment of responsiveness was assessed as a delayed-type hypersensitivity response, age did not affect responses.…”

Section: Impact Of Aging On Immune Healthmentioning

confidence: 99%