Effect of age and sex on copper-induced toxicity in theMacular mutant mouse

Abstract

It was determined if the sensitivity in macular mutant mouse to copper-induced toxicity was affected by sex or age. The sensitivity in 6-8-d-old or 3-4-wk-old macular mutant mouse to copper-induced toxicity was not affected by sex. However, 8-9-wk-old mutant females were more sensitive to copper-induced toxicity than mutant males. Furthermore, 6-8-d-old or 3-4-wk-old mutant males were more sensitive to copper-induced toxicity than 8-9-wk-old mutant males. However, age-related differences in sensitivity to copper-induced toxicity did not occur significantly in mutant females. On the other hand, in the case of normal mice, the sensitivity in 6-8-d-old or 3-4-wk-old mice to copper-induced toxicity was not also affected by sex. In contrast to mutant, however, 8-9-wk-old normal males were more sensitive to copper-induced toxicity than 8-9-wk-old normal females. Adult males were also more sensitive to copper-induced toxicity than 6-8-d-old or 3-4-wk-old males. However, age-related differences in sensitivity to copper-induced toxicity did not occur significantly in normal females. These results indicate that sex- and age-related differences in the copper-induced toxicity exist in macular mutant mice.

Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: Implications for Alzheimer β-amyloid pathology

“…impairs Cu transport, displayed a different set of sex and age differences in sensitivity to Cu-induced toxicity compared to a normal mouse [61]. This suggests that there are distinct sex differences in the regulation of Cu in mice, and that males and females have different capacities for the handling of excessive exposure to Cu.…”

“…Sex and age have been shown to affect the sensitivity of mice to Cu-induced toxicity [61]. Interestingly, the macular mutant mouse which carries a genetic defect that Fig.…”