Effect of age and exposure group on the onset of AIDS in heterosexual and homosexual HIV-infected patients

Carré, N; Deveau, Christiane; Bélanger, F.; Boufassa, Faroudy; Persoz, Anne; Jadand, C.; Rouzioux, Christine; Delfraissy, J. F.; Bucquet, D.

doi:10.1097/00002030-199406000-00012

Cited by 98 publications

(37 citation statements)

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“…In common with Kerlikowske and colleagues [13], we have also demonstrated in a much larger and more heterogeneous patient group that B2M is also a prognostic marker for death. It is well documented, mainly in groups of patients with haemophilia, that there is an association between increasing age and progression to AIDS, with older individuals progressing to AIDS more rapidly [22][23][24]. After adjustment for various demographic variables and the markers studied, we did not find a significant relationship between age and progression to AIDS.…”

Section: Discussioncontrasting

confidence: 56%

The relationship between beta-2-microglobulin, CD4 lymphocyte count, AIDS and death in HIV-positive individuals

et al. 1997

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The relationship, in 539 individuals infected with the human immunodeficiency virus (HIV), between two prognostic markers, the CD4 count and beta-2-microglobulin (B2M), and the development of the acquired immunodeficiency syndrome (AIDS) and death was investigated. Cox proportional hazards models were used to determine the risk of AIDS or death. In a multivariate model which adjusted for demographic factors and treatment, the most recent measurements of B2M (relative hazard (RH) 1·37 per g/l higher) and CD4 count (RH 2·17 per log-unit lower) were both significantly associated with the development of AIDS. Similarly, in a multivariate model which additionally adjusted for the development of AIDS as a time dependant covariate, there was a strong relationship with risk of death for the most recent measurements of B2M (RH 1·34 per g/l higher), and CD4 lymphocyte count (RH 1·91 per log-unit lower). A difference in the level of B2M could be used among patients with similar CD4 counts as an indicator of increased risk of progression to AIDS or death. Using the most recent values of these markers provides a better estimate of the risk of AIDS or death, compared to the more common method of analysis, where baseline values of the markers are used.

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Section: Discussioncontrasting

confidence: 56%

The relationship between beta-2-microglobulin, CD4 lymphocyte count, AIDS and death in HIV-positive individuals

et al. 1997

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“…In most studies of risk factors for progression, the endpoint is the onset of AIDS. Epidemiological studies have suggested a shorter AIDS incubation period in patients with symptomatic primary infection (SPI) 3,4 and among homosexual patients (relative to heterosexuals 5 and haemophiliacs 6 ). To date, age at infection is the most widely recognized risk factor for progression to AIDS.…”

mentioning

confidence: 99%

“…Among the sexually infected patients in the French SEROCO cohort, the 10-year rise in the risk of progression to AIDS has been estimated at 40%. 5 The pathophysiological phenomena underlying the influence of age are poorly known. Some authors explain it through the physiological decline in immune function, [11][12][13][14] which has been attributed to a quantitative 11 or qualitative 8 deficiency in CD4+ lymphocytes.…”

mentioning

confidence: 99%

Influence of age at infection on human immunodeficiency virus disease progression to different clinical endpoints: the SEROCO cohort (1988- 1994). The Seroco Study Group

Bélanger

Meyer²,

Carré³

et al. 1997

International Journal of Epidemiology

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Method. The influence of age at infection on progression of human immunodeficiency virus (HIV) disease to different clinical endpoints was studied among 393 HIV-seropositive adults selected from the French SEROCO cohort; follow-up lasted from January 1988 to November 1994. Selected patients had a known date of infection and were enrolled shortly after seroconversion. Age-associated risk ratios (RR) were estimated using the Cox model (age fitted as a continuous variable and RR expressed for each 10-year increment after adjustment for symptomatic primary infection and sexual preference). Results. Age had a weak influence on progression from the date of infection to the first category B event (crude RR = 1.15; adjusted RR = 1.09; 95% confidence interval [CI] : 0.89-1.36) but a marked influence on progression from the first category B to the first category C event (crude RR = 1.95; adjusted RR = 1.97; 95% CI : 1.37-2.79). Similar results were obtained after adjustment for the CD4 + cell count at enrolment. A qualitative CD4 + cell defect could explain the influence of age, but this remains to be confirmed. Conclusion. Age at infection should be included in the definition of CD4 + cell count thresholds for clinical management and treatment initiation. Risk factors for progression should be assessed according to the different clinical endpoints.

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“…11 Before the era of HAART, older age predicted a faster progression to clinical AIDS and death. 12 Although data from randomized-controlled trials in this area are lacking, a large retrospective study by the Kaiser Permanente Division of Research recently published showed that older-age patients beginning HAART actually had better virologic responses than younger patients and, despite blunted initial immunologic responses, had similar CD4 T-cell counts after three years of therapy. Higher HAART adherence was advanced as a possible explanation for the improved virologic responses seen in the older group.…”

Section: Agementioning

confidence: 99%

The Changing Face of HIV Infection

Towner¹

2008

TPJ

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Effect of age and exposure group on the onset of AIDS in heterosexual and homosexual HIV-infected patients

Cited by 98 publications

References 0 publications

The relationship between beta-2-microglobulin, CD4 lymphocyte count, AIDS and death in HIV-positive individuals

The relationship between beta-2-microglobulin, CD4 lymphocyte count, AIDS and death in HIV-positive individuals

Influence of age at infection on human immunodeficiency virus disease progression to different clinical endpoints: the SEROCO cohort (1988- 1994). The Seroco Study Group

The Changing Face of HIV Infection

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