Effect of aflatoxicosis on acetylcholinesterase activity in the brain and adenohypophysis of the male rat

In vitro inhibitory effect of aflatoxin B1 on acetylcholinesterase activity in mouse brain

“…We now show that AFB 1 inhibits AChE activity in mouse brain, and differentially affects its two molecular isoforms, G 4 and G 1 . This finding is in line with a previous study on the in vivo effect of acute aflatoxicosis on AChE activity in rat brain (Egbunike and Ikegwuonu, 1984). Our new information specifies the effect of AFB 1 on the enzyme's functional cholinergic and noncholinergic role.…”

“…In particular, ongoing studies are considering AFB 1 oral exposition instead of intraperitoneal treatment as already described in the rat (Egbunike and Ikegwuonu, 1984). Our in vitro findings suggest that AChE inhibition might explain the cholinergic symptoms described in farm animals and humans (Coppock et al, 1985;Cook et al, 1986;Hall et al, 1989;Vesonder et al, 1991;Hussein and Brasel, 2001).…”

“…It is the most frequent of all aflatoxins in contaminated food (IARC, 1993;Kennedy et al, 1998;Hussein and Brasel, 2001) and is the most active in evoking a contractile response on rumen intestine (Cook et al, 1986) and guinea-pig isolated ileum (Luzi et al, 2002). Moreover, a study investigating the effect of AFB 1 intraperitoneal acute and chronic treatment on acetylcholinesterase (AChE) activity suggests that AFB 1 changes acetylcholine turnover and hence cholinergic transmission in rat brain and adenohypophysis (Egbunike and Ikegwuonu, 1984).…”

Cholinesterases, a Target of Pharmacology and Toxicology

“…[109][110][111] ). Inhibition of AChE was confirmed after the onset of cholinergic symptoms following aflatoxin exposure 112 . The mechanism of aflatoxin interaction with AChE is not well-explained and more supporting experiments are needed.…”

Developmental exposure of aflatoxin B1 reversibly affects hippocampal neurogenesis targeting late-stage neural progenitor cells through suppression of cholinergic signaling in rats

“…Both cholinergic and glutamatergic inputs to the SGZ are important for maintaining adequate proliferation and differentiation of granule cell lineages (Cameron et al, 1995;Freund and Buzsáki, 1996). Previous studies have reported that AFB 1 chronic exposure decreases cholinergic and dopaminergic transmissions in the adult rat brain (Coulombe and Sharma, 1985;Egbunike and Ikegwuonu, 1984).…”