Effect of aerobic exercise training dose on liver fat and visceral adiposity

Keating, Shelley E.; Hackett, Daniel; Parker, Helen M.; O’Connor, Helen; Gerofi, James; Sainsbury, Amanda; Baker, Michael K.; Chuter, Vivienne; Caterson, Ian D.; George, Jacob

doi:10.1016/j.jhep.2015.02.022

Cited by 238 publications

(263 citation statements)

References 49 publications

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“…Liver and pancreas water signal amplitudes were quantified using Hankel-Lanczos squares singular values decomposition [27][28][29], and a five resonance model was employed to fit the lipid peaks [24,27,30]. A liver fat concentration ≥5.5% was considered consistent with the presence of non-alcoholic fatty liver disease (NAFLD), as described by previous studies quantifying liver fat using 1 H-MRS [31,32].…”

Section: Assessmentsmentioning

confidence: 99%

Reversal of type 2 diabetes in youth who adhere to a very-low-energy diet: a pilot study

et al. 2016

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Aims/hypothesis The aim of the study was to investigate whether a very-low-energy diet (VLED) is a feasible and acceptable treatment option for type 2 diabetes in children and adolescents, and whether adherence can lead to rapid weight loss, reversal of type 2 diabetes and reduced liver fat as seen in adult studies. Methods Eight participants with type 2 diabetes and obesity, aged 7-16 years, non-medicated (n = 1) or treated with metformin (n = 7) and in some cases insulin (n = 3), followed a VLED (<3360 kJ/day) for 8 weeks, then transitioned to a hypocaloric diet (∼6300 kJ/day) that they followed to 34 weeks. HbA 1c , fasting glucose and 2 h post-glucose load plasma glucose (2hG) were determined from fasting blood and an OGTT. Liver fat concentration was quantified using proton magnetic resonance spectroscopy. Adherence was defined as ≥5% weight loss during the 8 week VLED. Results Adherers (n = 5) and non-adherers (n = 3) had median weight loss of 7.5% and 0.5%, respectively, at 8 weeks. Only three out of eight participants met non-alcoholic fatty liver disease (NAFLD) criteria (≥5.5%) at 8 weeks, compared with eight out of eight at baseline. The three participants on insulin therapy at baseline were able to cease therapy during the 8 week VLED. At 34 weeks, adherers (n = 5) achieved 12.3% weight loss, none met NAFLD criteria and four did not meet American Diabetes Association criteria for type 2 diabetes.

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Section: Assessmentsmentioning

confidence: 99%

Reversal of type 2 diabetes in youth who adhere to a very-low-energy diet: a pilot study

et al. 2016

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“…The available evidence to date suggests a benefit of exercise to decrease fatty liver in NAFLD [13][14][15][16]23], and the question of the optimum prescribed 'dose' of exercise for all liver diseases [14] and the effect of aerobic exercise on liver fat [24] have recently been examined. These analyses show that it remains uncertain as to what exercise should be advised and how intense (and for how long), that exercise needs to be, in order to influence liver fat.…”

Section: Interestingly For Both Incident Fatty Liver (Supplementarymentioning

confidence: 99%

Effect of exercise on the development of new fatty liver and the resolution of existing fatty liver

Sung

Ryu

Lee

et al. 2016

Journal of Hepatology

104

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“…Nine randomized control trials and four uncontrolled studies have investigated the effects of aerobic training in NAFLD (Table 1) [9][10][11][19][20][21][22][23][24][25][26][27][28]. All of the studies included at least one aerobic training experimental group, with three studies containing multiple aerobic training groups of differing exercise intensities [11,22,24].…”

Section: Aerobic Trainingmentioning

confidence: 99%

Exercise Training as Treatment of Nonalcoholic Fatty Liver Disease

Glass

Radia

Kraus

et al. 2017

JFMK

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Nonalcoholic Fatty Liver Disease (NAFLD) is a growing health epidemic in developed countries with increased prevalence in obese and diabetic populations. Exercise is an established and essential component of lifestyle modification for NAFLD disease management. Despite numerous studies reporting exercise-mediated improvements in NAFLD, there remains a large gap in our knowledge of how to optimize exercise prescriptions and whether the benefits of exercise extend beyond improvements in liver fat. In this review, we summarize studies that have investigated the independent effects of exercise training on liver enzymes, hepatic fat, and histologic markers in NAFLD. Overall, 12-weeks of aerobic, resistance, the combination of aerobic and resistance, and novel training modalities, including acceleration and hybrid training, significantly improve liver enzymes and hepatic fat. The greatest benefits in NAFLD may occur through the combination of aerobic and resistance training that targets both cardiorespiratory fitness, and mediators of skeletal muscle, known as myokines. Understanding the role of myokines in the beneficial effects of exercise in NAFLD may identify future therapeutic targets that can be modified with tailored exercise prescriptions.

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Effect of aerobic exercise training dose on liver fat and visceral adiposity

Cited by 238 publications

References 49 publications

Reversal of type 2 diabetes in youth who adhere to a very-low-energy diet: a pilot study

Reversal of type 2 diabetes in youth who adhere to a very-low-energy diet: a pilot study

Effect of exercise on the development of new fatty liver and the resolution of existing fatty liver

Exercise Training as Treatment of Nonalcoholic Fatty Liver Disease

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