Effect of aerobic exercise training on oxidative stress in patients with type 2 diabetes mellitus

Nojima, Hideki; Watanabe, Hiroshi; Yamane, Kiminori; Kitahara, Yoshihiro; Sekikawa, Kiyokazu; Yamamoto, Hideya; Yokoyama, Akihito; Inamizu, Tsutomu; Asahara, Toshimasa; Kohno, Nobuoki

doi:10.1016/j.metabol.2007.08.021

Cited by 82 publications

(57 citation statements)

References 42 publications

(37 reference statements)

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“…These data agree with studies indicating that there is a period during training which is characterized by changes in oxidative stress markers (Gomez-Cabrera et al, 2008;Nojima et al, 2008). Thus, De Moffarts et al (2004) observed increases in GSH-Px and SOD activity in Standardbred horses after twelve weeks of aerobic and anaerobic training, while Oztasan et al (2004) found SOD and GSH-Px increases in rats after eight weeks of training.…”

Section: Discussionsupporting

confidence: 86%

“…Exercise is associated with increases in both ATP requirements and aerobic and/or anaerobic metabolism, which result in higher levels of ROS and RNS (Davis et al, 1982;Jackson et al, 1985;Viguie et al, 1993;Inoue et al, 1993;Sen, 1995;Nojima et al, 2008). Thus, when exercise is strenuous it causes oxidative stress and cell damage, but when done in moderation, it increases the expression of antioxidant enzymes (Gomez-Cabrera et al, 2008).…”

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confidence: 99%

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Effects of an aerobic training program on oxidative stress biomarkers in bulls

Escribano¹,

Túnez²,

Requena³

et al. 2010

Vet. Med. - Czech

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ABSTRACT:The aim of this study was to evaluate the effect of aerobic training (16 weeks -T1 and 24 weeks -T2) on oxidative stress biomarkers. To this end, GSH, GSH-peroxidase (GSH-Px) and catalase (CAT) activity were analysed in plasma. Nine bulls (3-4 years), were included in this work. The exercise training protocol was performed in a track ("taurodromo") three days per week for 24 weeks and consisted of 400 m warming up, 1200 m to 4-5 m/s, two minutes' resting, 1200 m to 4-5 m/s and, finally, 400 m walking. The results reflected that GSH-Px activity was higher at T1 (6.18 ± 0.45) than at baseline (T0; 2.31 ± 0.08) while the GSH level (2.98 ± 0.37) was lower vs. T0 (14.59 ± 3.40). Moreover, there were significant increases in GSH-Px (18.23 ± 1.36) and CAT (2.52 ± 0.04) activities and the recovery of basal values in GSH (11.75 ± 2.84) in T2. In conclusion, the type of training carried out in this study involved two well-defined stages: (i) a period of perturbation, followed by (ii) adaptation. The former stage was characterised by the induction of oxidative stress manifested as a decrease in the GSH, and the latter (T2) by the recovery of this non-enzymatic antioxidant.

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Section: Discussionsupporting

confidence: 86%

mentioning

confidence: 99%

Effects of an aerobic training program on oxidative stress biomarkers in bulls

Escribano¹,

Túnez²,

Requena³

et al. 2010

Vet. Med. - Czech

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“…The addition of specific antihypertensive medications suggested to have antioxidative effects, (16) as well as the inclusion of nonpharmaceutical antioxidant therapy (e.g. exercise, vitamin supplementation, and a diet rich in fruits and vegetables) (28)(29)(30)(31) may be included in the treatment regimen of these patients.…”

Section: Discussionmentioning

confidence: 99%

Association between urinary 8-OHdG and pulse wave velocity in hypertensive patients with type 2 diabetes mellitus

Kotani

Yamada²

2014

smedj

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The Asia-Pacific region is facing an epidemic of type 2 diabetes mellitus (T2DM), paralleled by high rates of cardiovascular disease (CVD).(1,2) Hypertension (HT) remains a major risk factor for CVD in the region. On DNA oxidation, a hydroxyl group is added to the guanine molecule to form 8-hydroxyguanine, which on oxidative modification yields the product, 8-hydroxy-2'-deoxyguanosine (8-OHdG). (7,8) Hyperglycaemia promotes glucose oxidation and protein glycation, impairs DNA repair with resultant DNA cleavage, and generates reactive oxygen species, thereby leading to increased oxidative stress. (4,7,8) Similarly, HT is accompanied by the formation of advanced glycation end products, and thereby increased oxidative stress and DNA damage. (9,10) For these reasons, the measurement of 8-OHdG has been used by various researchers to evaluate the DNA oxidation associated with the pathophysiology of T2DM and HT. (4,(11)(12)(13)(14)(15)(16) A study by Nishikawa et al found that urinary 8-OHdG levels were increased in T2DM patients with poor glycaemic control, (4) while a study by Espinosa et al reported that urinary 8-OHdG levels were increased in patients with HT.However, Roselló-Lletí et al demonstrated that patients with HT and DM do not exhibit any differences with regard to 8-OHdG levels when compared to patients with HT but no DM.Espinosa et al also reported that 8-OHdG levels were reduced following antihypertensive treatment in patients with HT.(13) Studies suggest lowered urinary 8-OHdG levels upon intervention with antidiabetic agents in T2DM patients, Barengo and Tuomilehto reported that the presence of HT as a comorbidity in the hyperglycaemic state increased CVD

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“…However, physical training, when carefully planned, may improve both antioxidative defense mechanisms 5,6,8 and the oxidative capacity of tissues, 9 which may decrease the magnitude of the oxidative attack 10,11 and prevent its deleterious effects 12,13 . Previous studies with animal models have confirmed that physical training positively affects the redox state of innumerable cells and tissues and may improve oxidative stress parameters 5,10,14,15 . Those findings might be applicable to human beings as there is a link between the different animal species and data found in animal studies may be extrapolated to the human species.…”

Section: Introductionmentioning

confidence: 91%

Efeito de diferentes frequências semanais de treinamento sobre parâmetros de estresse oxidativo. DOI: 10.5007/1980-0037.2012v14n1p52

Tromm

Rosa

Bom

et al. 2012

Rev. Bras. Cineantropom. Desempenho Hum.

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-Intense muscle contraction induced by physical exercise increases the production of reactive oxygen species, which causes oxidative stress in several organs, such as the liver and the heart. Physical training may increase antioxidative defenses and decrease oxidative stress. However, it is not clear what training frequency improves oxidative stress parameters. This study evaluated the effect of training two and three times a week on oxidative stress biomarkers in the liver and the heart. Eighteen young male mice (CF1) weighing 30 to 35 g were divided into three groups (n=6): no training (NT); twice a week training (T2); and three times a week training (T3). The training program lasted eight weeks, and the animals were killed 48 hours after the last training session. The liver and the heart were removed and stored at -70o C. The following analyses were conducted: thiobarbituric acid reactive substances, protein carbonylation, total thiol content, superoxide dismutase, catalase and glutathione peroxidase. Oxidative damage was reduced only in the T3 group, and there was an increase in total thiol content, supeoxidase dismutase and catalase in T3 when compared with the NT group. Glutathione peroxidase was not significantly different between groups. Only training three times a week seemed to reduce oxidative stress and increase the efficiency of the antioxidant system in mice. Key words: Antioxidant enzymes; Oxidative damage; Physical exercise; Training frequency. Resumo -Durante a contração muscular intensa induzida pelo exercício físico, há aumento na produção de espécies reativas de oxigênio, ocasionando estresse oxidativo em diversos órgãos, dentre eles o fígado e o coração. O treinamento físico pode aumentar as defesas antioxidantes e diminuir o estresse oxidativo. Contudo, ainda existem dúvidas sobre a frequência de treinamento necessária para melhorar parâmetros de estresse oxidativo. Este trabalho tem como objetivo verificar o efeito das frequências de duas e três vezes de exercício por semana sobre biomarcadores de estresse oxidativo no fígado e coração. Foram utilizados 18 camundongos machos (CF1), jovens (30 a 35g) divididos em grupos (n=6/ grupo): não treinado (NT); treinado duas vezes por semana (T2) e treinado três vezes por semana (T3

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Effect of aerobic exercise training on oxidative stress in patients with type 2 diabetes mellitus

Cited by 82 publications

References 42 publications

Effects of an aerobic training program on oxidative stress biomarkers in bulls

Effects of an aerobic training program on oxidative stress biomarkers in bulls

Association between urinary 8-OHdG and pulse wave velocity in hypertensive patients with type 2 diabetes mellitus

Efeito de diferentes frequências semanais de treinamento sobre parâmetros de estresse oxidativo. DOI: 10.5007/1980-0037.2012v14n1p52

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