Effect of aerobic exercise on cancer‐associated cognitive impairment: A proof‐of‐concept RCT

Abstract

Background Change in cognitive ability is a commonly reported adverse effect by breast can-

Randomized controlled trial of increasing physical activity on objectively measured and self‐reported cognitive functioning among breast cancer survivors: The memory & motion study

“…However, of 9 examined cognitive domains, only Processing Speed had significantly greater improvements in the exercise arm compared with the control arm. These findings are consistent with a recent randomized controlled trial of 19 breast cancer survivors in which the exercise arm had greater improvements only for a measure of processing speed and a cross‐sectional study of 136 breast cancer survivors demonstrating that accelerometer‐measured physical activity was only related to 1 cognitive domain: processing speed . Although the cross‐sectional study was also conducted by investigators from the current study, it concerned a different sample of breast cancer survivors and used a different neurocognitive test.…”

“…However, of 9 examined cognitive domains, only Processing Speed had significantly greater improvements in the exercise arm compared with the control arm. These findings are consistent with a recent randomized controlled trial of 19 breast cancer survivors in which the exercise arm had greater improvements only for a measure of processing speed 23 and a cross-sectional study of 136 breast cancer survivors demonstrating that…”

“…This recent study in 19 breast cancer survivors enrolled in a 24-week physical activity randomized controlled trial indicated that the exercise arm had greater improvements in a measure of processing speed compared with the control group. 23 Several crosssectional studies in cancer survivors using objective measures of cognition have indicated that greater physical activity is associated with several domains of cognition, including information processing speed, 24 memory, 25 executive functioning, 26 and attention. 26 These studies lend support to the hypothesis that increasing physical activity may be an effective intervention for improving cognition in breast cancer survivors.…”

Neurocognitive dysfunction in hematopoietic cell transplant recipients: expert review from the late effects and Quality of Life Working Committee of the CIBMTR and complications and Quality of Life Working Party of the EBMT

“…Campbell and colleagues found aerobic exercise improved neurocognitive function in cancer patients. 126 Current investigation is ongoing to examine the potential benefit of exercise on neurocognitive dysfunction (NCT02533947) in adults. Lastly, health behaviors such as abstinence from tobacco use, and consuming alcohol in moderation, may support healthy neurocognitive functioning following HCT.…”

Protocol for Moving On: a randomized controlled trial to increase outcome expectations and exercise among breast cancer survivors

“…Many of these effects may be decreased by exercise. For example, exercise has been shown to improve body image, self‐esteem, emotional well‐being, social functioning, anxiety, fatigue, sexuality (Mishra et al., ), pain (Irwin et al., ), cardiac disease risk, bone health (Kirkham, Bland, Sayyari, Campbell, & Davis, ) and possibly cognitive function (Campbell et al., ; Myers, Koleck, Sereika, Conley, & Bender, ). Additional exercise benefits for breast cancer survivors may include improved longevity.…”