Effect of aerobic exercise intervention on DDT degradation and oxidative stress in rats

Abstract

Male Wistar rats were randomly assigned into control (C), DDT without exercise training (D), and DDT plus exercise training (DE) groups. The rats were treated as follows: DDT exposure to D and DE groups at the first 2 weeks; aerobic exercise treatment only to the DE group from the 1st day until the rats are killed. DDT levels in excrements, muscle, liver, serum, and hearts were analyzed. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) levels were determined. Aerobic exercise accelerated the degradation of DDT primarily to DDE due to better oxygen availability and aerobic condition and promoted the degradation of DDT. Cumulative oxidative damage of DDT and exercise led to significant decrease of SOD level. Exercise resulted in consistent increase in SOD activity. Aerobic exercise enhanced activities of CAT and GSH-Px and promoted MDA scavenging. Results suggested that exercise can accelerate adaptive responses to oxidative stress and activate antioxidant enzymes activities. Exercise can also facilitate the reduction of DDT-induced oxidative damage and promoted DDT degradation. This study strongly implicated the positive effect of exercise training on DDT-induced liver oxidative stress.

Lifestyle interventions for non-alcoholic fatty liver disease

“…Moderate physical activity exercise (such as 30 min of aerobic exercise 4 times a week) is also considered as one of the preferred methods of weight loss (Ahmed, 2015). Aerobic exercise also does not only boost activity and expression of antioxidant enzymes but also facilitate reduction of dichlorodiphenyltrichloroethane (DDT)- induced oxidative damage primarily due to better oxygen availability (Li et al, 2017). In general, the superiority of exercise to other lifestyle interventions is noticeable in the improvement of insulin sensitivity and BMI reduction (Zou et al, 2018).…”

Emerging contaminants and priority substances in marine sediments from Cartagena Bay and the Grand Marsh of Santa Marta (Ramsar site), Colombia

“…In the environment, dichlorodiphenyltrichloroethane degrades into its metabolites p,p ′-DDD and p,p ′-DDE under anaerobic and aerobic conditions, respectively (Heberer & Dünnbier, 1999 ). In this study, the DDD/DDE ratio was used to identify the type of degradation DDT had undergone (e.g., high DDD/DDE ratio indicates anaerobic conditions, and vice-versa) (Li et al, 2017 ). In the present study, the data showed a high DDD/DDE ratio in the dry season (58%), indicating the presence of anaerobic conditions ( p,p ′-DDD).…”

Current Studies and Future Directions of Exercise Therapy for Muscle Atrophy Induced by Heart Failure

“…Four weeks of treadmill exercise in mice enhanced the expression of SOD in gastrocnemius mitochondria, inhibited the chain reaction of free radical production, reduced the production of free radicals, and avoided muscle cell damage caused by imbalance of cell oxidative stress level (48). In clinical human experiments, it is found that proper aerobic exercise can improve the activities of SOD, glutathione peroxidase 1 (GSH-Px) and catalase (CAT), and accelerate the speed and ability of the body to remove free radicals and peroxide products (49).…”